Reviewing the history of HIV-1 : spread of subtype B in the americas
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/200970 |
Resumo: | The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in spreading the virus to the United States. However, the exact pathways taken during the establishment of the pandemic in the Americas remain unclear. Here, we propose a geographical scenario for the dissemination of HIV-1B in the Americas, based on phylogenetic and genetic statistical analyses of 313 available sequences of the pol gene from 27 countries. Maximum likelihood and Bayesian inference methods were used to explore the phylogenetic relationships between HIV-1B sequences, and molecular variance estimates were analyzed to infer the genetic structure of the viral population. We found that the initial dissemination and subsequent spread of subtype B in the Americas occurred via a single introduction event in the Caribbean around 1964 (1950–1967). Phylogenetic trees present evidence of several primary outbreaks in countries in South America, directly seeded by the Caribbean epidemic. Cuba is an exception insofar as its epidemic seems to have been introduced from South America. One clade comprising isolates from different countries emerged in the most-derived branches, reflecting the intense circulation of the virus throughout the American continents. Statistical analysis supports the genetic compartmentalization of the virus among the Americas, with a close relationship between the South American and Caribbean epidemics. These findings reflect the complex establishment of the HIV-1B pandemic and contribute to our understanding between the migration process of human populations and virus diffusion. |
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Junqueira, Dennis MaletichMedeiros, Rubia Marília deMatte, Maria Cristina CottaAraujo, Leonardo Augusto LuvisonChies, Jose Artur BogoProlla, Patrícia AshtonAlmeida, Sabrina Esteves de Matos2019-10-24T03:49:12Z20111932-6203http://hdl.handle.net/10183/200970000818351The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in spreading the virus to the United States. However, the exact pathways taken during the establishment of the pandemic in the Americas remain unclear. Here, we propose a geographical scenario for the dissemination of HIV-1B in the Americas, based on phylogenetic and genetic statistical analyses of 313 available sequences of the pol gene from 27 countries. Maximum likelihood and Bayesian inference methods were used to explore the phylogenetic relationships between HIV-1B sequences, and molecular variance estimates were analyzed to infer the genetic structure of the viral population. We found that the initial dissemination and subsequent spread of subtype B in the Americas occurred via a single introduction event in the Caribbean around 1964 (1950–1967). Phylogenetic trees present evidence of several primary outbreaks in countries in South America, directly seeded by the Caribbean epidemic. Cuba is an exception insofar as its epidemic seems to have been introduced from South America. One clade comprising isolates from different countries emerged in the most-derived branches, reflecting the intense circulation of the virus throughout the American continents. Statistical analysis supports the genetic compartmentalization of the virus among the Americas, with a close relationship between the South American and Caribbean epidemics. These findings reflect the complex establishment of the HIV-1B pandemic and contribute to our understanding between the migration process of human populations and virus diffusion.application/pdfengPloS one. San Francisco. Vol. 6, no. 11 (Nov. 2011), e27489, 10 p.HIV-1HistóriaReviewing the history of HIV-1 : spread of subtype B in the americasEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT000818351.pdf.txt000818351.pdf.txtExtracted Texttext/plain45853http://www.lume.ufrgs.br/bitstream/10183/200970/2/000818351.pdf.txta68aa954c5b5ff887408d78d6a8ef727MD52ORIGINAL000818351.pdfTexto completo (inglês)application/pdf1085607http://www.lume.ufrgs.br/bitstream/10183/200970/1/000818351.pdfe0c9cebd3c6dfbe350438e8af22c37cbMD5110183/2009702022-11-12 05:59:58.735636oai:www.lume.ufrgs.br:10183/200970Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-11-12T07:59:58Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
title |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
spellingShingle |
Reviewing the history of HIV-1 : spread of subtype B in the americas Junqueira, Dennis Maletich HIV-1 História |
title_short |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
title_full |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
title_fullStr |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
title_full_unstemmed |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
title_sort |
Reviewing the history of HIV-1 : spread of subtype B in the americas |
author |
Junqueira, Dennis Maletich |
author_facet |
Junqueira, Dennis Maletich Medeiros, Rubia Marília de Matte, Maria Cristina Cotta Araujo, Leonardo Augusto Luvison Chies, Jose Artur Bogo Prolla, Patrícia Ashton Almeida, Sabrina Esteves de Matos |
author_role |
author |
author2 |
Medeiros, Rubia Marília de Matte, Maria Cristina Cotta Araujo, Leonardo Augusto Luvison Chies, Jose Artur Bogo Prolla, Patrícia Ashton Almeida, Sabrina Esteves de Matos |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Junqueira, Dennis Maletich Medeiros, Rubia Marília de Matte, Maria Cristina Cotta Araujo, Leonardo Augusto Luvison Chies, Jose Artur Bogo Prolla, Patrícia Ashton Almeida, Sabrina Esteves de Matos |
dc.subject.por.fl_str_mv |
HIV-1 História |
topic |
HIV-1 História |
description |
The dispersal of HIV-1 subtype B (HIV-1B) is a reflection of the movement of human populations in response to social, political, and geographical issues. The initial dissemination of HIV-1B outside Africa seems to have included the passive involvement of human populations from the Caribbean in spreading the virus to the United States. However, the exact pathways taken during the establishment of the pandemic in the Americas remain unclear. Here, we propose a geographical scenario for the dissemination of HIV-1B in the Americas, based on phylogenetic and genetic statistical analyses of 313 available sequences of the pol gene from 27 countries. Maximum likelihood and Bayesian inference methods were used to explore the phylogenetic relationships between HIV-1B sequences, and molecular variance estimates were analyzed to infer the genetic structure of the viral population. We found that the initial dissemination and subsequent spread of subtype B in the Americas occurred via a single introduction event in the Caribbean around 1964 (1950–1967). Phylogenetic trees present evidence of several primary outbreaks in countries in South America, directly seeded by the Caribbean epidemic. Cuba is an exception insofar as its epidemic seems to have been introduced from South America. One clade comprising isolates from different countries emerged in the most-derived branches, reflecting the intense circulation of the virus throughout the American continents. Statistical analysis supports the genetic compartmentalization of the virus among the Americas, with a close relationship between the South American and Caribbean epidemics. These findings reflect the complex establishment of the HIV-1B pandemic and contribute to our understanding between the migration process of human populations and virus diffusion. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
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2019-10-24T03:49:12Z |
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http://hdl.handle.net/10183/200970 |
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1932-6203 |
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000818351 |
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http://hdl.handle.net/10183/200970 |
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eng |
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PloS one. San Francisco. Vol. 6, no. 11 (Nov. 2011), e27489, 10 p. |
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