EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors

Detalhes bibliográficos
Autor(a) principal: Souza, Bárbara Kunzler
Data de Publicação: 2021
Outros Autores: Freire, Natália Hogetop, Jaeger, Mariane da Cunha, Farias, Caroline Brunetto de, Brunetto, Algemir Lunardi, Brunetto, Andre Tessainer, Roesler, Rafael
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/236683
Resumo: Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors.
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spelling Souza, Bárbara KunzlerFreire, Natália HogetopJaeger, Mariane da CunhaFarias, Caroline Brunetto deBrunetto, Algemir LunardiBrunetto, Andre TessainerRoesler, Rafael2022-04-07T04:47:52Z20211422-0067http://hdl.handle.net/10183/236683001137381Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors.application/pdfengInternational journal of molecular sciences. Basel. Vol. 22, no. 20 (Oct. 2021), 11292, 11 p.Histona-lisina N-metiltransferaseMetilação de DNAEpigênese genéticaNeoplasias encefálicasG9aEHMT2GlioblastomaMedulloblastomaEpigeneticsBrain tumorEHMT2/G9a as an epigenetic target in pediatric and adult brain tumorsEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001137381.pdf.txt001137381.pdf.txtExtracted Texttext/plain55775http://www.lume.ufrgs.br/bitstream/10183/236683/2/001137381.pdf.txt68f74b9172cd1397737e2fb29768d0a3MD52ORIGINAL001137381.pdfTexto completo (inglês)application/pdf580656http://www.lume.ufrgs.br/bitstream/10183/236683/1/001137381.pdf8ead887b57a3df3d2b174b113759d333MD5110183/2366832022-04-20 04:47:45.643673oai:www.lume.ufrgs.br:10183/236683Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2022-04-20T07:47:45Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
title EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
spellingShingle EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
Souza, Bárbara Kunzler
Histona-lisina N-metiltransferase
Metilação de DNA
Epigênese genética
Neoplasias encefálicas
G9a
EHMT2
Glioblastoma
Medulloblastoma
Epigenetics
Brain tumor
title_short EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
title_full EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
title_fullStr EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
title_full_unstemmed EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
title_sort EHMT2/G9a as an epigenetic target in pediatric and adult brain tumors
author Souza, Bárbara Kunzler
author_facet Souza, Bárbara Kunzler
Freire, Natália Hogetop
Jaeger, Mariane da Cunha
Farias, Caroline Brunetto de
Brunetto, Algemir Lunardi
Brunetto, Andre Tessainer
Roesler, Rafael
author_role author
author2 Freire, Natália Hogetop
Jaeger, Mariane da Cunha
Farias, Caroline Brunetto de
Brunetto, Algemir Lunardi
Brunetto, Andre Tessainer
Roesler, Rafael
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Bárbara Kunzler
Freire, Natália Hogetop
Jaeger, Mariane da Cunha
Farias, Caroline Brunetto de
Brunetto, Algemir Lunardi
Brunetto, Andre Tessainer
Roesler, Rafael
dc.subject.por.fl_str_mv Histona-lisina N-metiltransferase
Metilação de DNA
Epigênese genética
Neoplasias encefálicas
topic Histona-lisina N-metiltransferase
Metilação de DNA
Epigênese genética
Neoplasias encefálicas
G9a
EHMT2
Glioblastoma
Medulloblastoma
Epigenetics
Brain tumor
dc.subject.eng.fl_str_mv G9a
EHMT2
Glioblastoma
Medulloblastoma
Epigenetics
Brain tumor
description Epigenetic mechanisms, including post-translational modifications of DNA and histones that influence chromatin structure, regulate gene expression during normal development and are also involved in carcinogenesis and cancer progression. The histone methyltransferase G9a (euchromatic histone lysine methyltransferase 2, EHMT2), which mostly mediates mono- and dimethylation by histone H3 lysine 9 (H3K9), influences gene expression involved in embryonic development and tissue differentiation. Overexpression of G9a has been observed in several cancer types, and different classes of G9a inhibitors have been developed as potential anticancer agents. Here, we review the emerging evidence suggesting the involvement of changes in G9a activity in brain tumors, namely glioblastoma (GBM), the main type of primary malignant brain cancer in adults, and medulloblastoma (MB), the most common type of malignant brain cancer in children. We also discuss the role of G9a in neuroblastoma (NB) and the drug development of G9a inhibitors.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-04-07T04:47:52Z
dc.type.driver.fl_str_mv Estrangeiro
info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10183/236683
dc.identifier.issn.pt_BR.fl_str_mv 1422-0067
dc.identifier.nrb.pt_BR.fl_str_mv 001137381
identifier_str_mv 1422-0067
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url http://hdl.handle.net/10183/236683
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv International journal of molecular sciences. Basel. Vol. 22, no. 20 (Oct. 2021), 11292, 11 p.
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instacron_str UFRGS
institution UFRGS
reponame_str Repositório Institucional da UFRGS
collection Repositório Institucional da UFRGS
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