An update on the epigenetics of glioblastomas

• Autor(a) principal: Ferreira, Wallax Augusto Silva
• Data de Publicação: 2016
• Outros Autores: Pinheiro, Danilo do Rosário, Costa Junior, Carlos Antonio da, Rodrigues, Symara Antunes, Araújo, Mariana Diniz, Barros, Mariceli Baia Leão, Teixeira, Adriana Corrêa de Souza, Faro, Thamirys Aline Silva, Burbano, Rommel Rodriguez, Oliveira, Edivaldo Herculano Correa de, Harada, Maria Lúcia, Borges, Bárbara do Nascimento
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/2493
• topic: Neoplasias Encefálicas; Biomarcadores / líquido cefalorraquidiano; Carcinogênese; Glioblastoma; Neoplasias Encefálicas; Metilação de DNA; Epigênese Genética; Biomarcadores Tumorais; Astrocitoma

Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.