Population medical genetics : translating science to the community
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/199807 |
Resumo: | Rare genetic disorders are currently in the spotlight due to the elevated number of different conditions and significant total number of affected patients. The study of these disorders is extremely helpful for the elucidation of physiological processes related with complex disorders. Isolated populations are instrumental for the study of genetic disorders, considering their homogeneity and high proportion of affected patients in a small geographic area. These favorable conditions lead to the creation of a new discipline, known as "population medical genetics", which integrates medical genetics, population genetics, epidemiological genetics and community genetics. In order to develop practical activities in this new discipline, the National Institute of Population Medical Genetics (INaGeMP) was created in 2008 in Brazil. INaGeMP has developed several tools and funded numerous research activities. In this review, we highlight three successful projects developed in the first 10 years of INaGeMP activities (2008-2018): a newborn screening pilot study for MPS VI in Northeast Brazil, the study of Machado-Joseph disease in Brazilian families with Azorian ancestry, and the high twinning rate in a small town in southern Brazil. The results of these projects in terms of scientific output and contributions to the affected communities highlight the success and importance of INaGeMP. |
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Giugliani, RobertoBender, FernandaCouto, Rowena Rubim Silva doBochernitsan, Aline NemetzFacchin, Ana Carolina BrusiusBurin, Maira GraeffAmorim, TatianaAcosta, Angelina XavierPurificação, Antônio Conceição daLeistner-Segal, SandraPereira, Maria Luiza SaraivaJardim, Laura BannachMatte, Ursula da SilveiraRiegel, MariluceSantos, Augusto César Cardoso dosRodrigues, Graziella RamosOliveira, Marcelo Zagonel deRibeiro, Alice TaglianiHeck, Selia MariaDresch, VanusaFaccini, Lavinia SchulerKubaski, Francyne2019-09-27T03:45:07Z20191415-4757http://hdl.handle.net/10183/199807001100682Rare genetic disorders are currently in the spotlight due to the elevated number of different conditions and significant total number of affected patients. The study of these disorders is extremely helpful for the elucidation of physiological processes related with complex disorders. Isolated populations are instrumental for the study of genetic disorders, considering their homogeneity and high proportion of affected patients in a small geographic area. These favorable conditions lead to the creation of a new discipline, known as "population medical genetics", which integrates medical genetics, population genetics, epidemiological genetics and community genetics. In order to develop practical activities in this new discipline, the National Institute of Population Medical Genetics (INaGeMP) was created in 2008 in Brazil. INaGeMP has developed several tools and funded numerous research activities. In this review, we highlight three successful projects developed in the first 10 years of INaGeMP activities (2008-2018): a newborn screening pilot study for MPS VI in Northeast Brazil, the study of Machado-Joseph disease in Brazilian families with Azorian ancestry, and the high twinning rate in a small town in southern Brazil. The results of these projects in terms of scientific output and contributions to the affected communities highlight the success and importance of INaGeMP.application/pdfengGenetics and molecular biology. Ribeirão Preto. Vol. 42, n. 1, suppl. 1 (2019), p. 312-320GenéticaGenética médicaEstatística e dados numéricosMétodosMapeamento cromossomicoDoenças genéticas inatasFisiopatologiaEpidemiologiaDiagnósticoTerapêuticaPopulation Medical Geneticsgenetic clustersfounder effectpopulation isolatesPopulation medical genetics : translating science to the communityinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001100682.pdf.txt001100682.pdf.txtExtracted Texttext/plain43431http://www.lume.ufrgs.br/bitstream/10183/199807/2/001100682.pdf.txt7d286f9fd4f9d974ad24d4406e8feeffMD52ORIGINAL001100682.pdfTexto completo (inglês)application/pdf1891860http://www.lume.ufrgs.br/bitstream/10183/199807/1/001100682.pdfc716beba245431ad711434a332564ae2MD5110183/1998072023-10-20 03:38:00.67798oai:www.lume.ufrgs.br:10183/199807Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-20T06:38Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Population medical genetics : translating science to the community |
title |
Population medical genetics : translating science to the community |
spellingShingle |
Population medical genetics : translating science to the community Giugliani, Roberto Genética Genética médica Estatística e dados numéricos Métodos Mapeamento cromossomico Doenças genéticas inatas Fisiopatologia Epidemiologia Diagnóstico Terapêutica Population Medical Genetics genetic clusters founder effect population isolates |
title_short |
Population medical genetics : translating science to the community |
title_full |
Population medical genetics : translating science to the community |
title_fullStr |
Population medical genetics : translating science to the community |
title_full_unstemmed |
Population medical genetics : translating science to the community |
title_sort |
Population medical genetics : translating science to the community |
author |
Giugliani, Roberto |
author_facet |
Giugliani, Roberto Bender, Fernanda Couto, Rowena Rubim Silva do Bochernitsan, Aline Nemetz Facchin, Ana Carolina Brusius Burin, Maira Graeff Amorim, Tatiana Acosta, Angelina Xavier Purificação, Antônio Conceição da Leistner-Segal, Sandra Pereira, Maria Luiza Saraiva Jardim, Laura Bannach Matte, Ursula da Silveira Riegel, Mariluce Santos, Augusto César Cardoso dos Rodrigues, Graziella Ramos Oliveira, Marcelo Zagonel de Ribeiro, Alice Tagliani Heck, Selia Maria Dresch, Vanusa Faccini, Lavinia Schuler Kubaski, Francyne |
author_role |
author |
author2 |
Bender, Fernanda Couto, Rowena Rubim Silva do Bochernitsan, Aline Nemetz Facchin, Ana Carolina Brusius Burin, Maira Graeff Amorim, Tatiana Acosta, Angelina Xavier Purificação, Antônio Conceição da Leistner-Segal, Sandra Pereira, Maria Luiza Saraiva Jardim, Laura Bannach Matte, Ursula da Silveira Riegel, Mariluce Santos, Augusto César Cardoso dos Rodrigues, Graziella Ramos Oliveira, Marcelo Zagonel de Ribeiro, Alice Tagliani Heck, Selia Maria Dresch, Vanusa Faccini, Lavinia Schuler Kubaski, Francyne |
author2_role |
author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Giugliani, Roberto Bender, Fernanda Couto, Rowena Rubim Silva do Bochernitsan, Aline Nemetz Facchin, Ana Carolina Brusius Burin, Maira Graeff Amorim, Tatiana Acosta, Angelina Xavier Purificação, Antônio Conceição da Leistner-Segal, Sandra Pereira, Maria Luiza Saraiva Jardim, Laura Bannach Matte, Ursula da Silveira Riegel, Mariluce Santos, Augusto César Cardoso dos Rodrigues, Graziella Ramos Oliveira, Marcelo Zagonel de Ribeiro, Alice Tagliani Heck, Selia Maria Dresch, Vanusa Faccini, Lavinia Schuler Kubaski, Francyne |
dc.subject.por.fl_str_mv |
Genética Genética médica Estatística e dados numéricos Métodos Mapeamento cromossomico Doenças genéticas inatas Fisiopatologia Epidemiologia Diagnóstico Terapêutica |
topic |
Genética Genética médica Estatística e dados numéricos Métodos Mapeamento cromossomico Doenças genéticas inatas Fisiopatologia Epidemiologia Diagnóstico Terapêutica Population Medical Genetics genetic clusters founder effect population isolates |
dc.subject.eng.fl_str_mv |
Population Medical Genetics genetic clusters founder effect population isolates |
description |
Rare genetic disorders are currently in the spotlight due to the elevated number of different conditions and significant total number of affected patients. The study of these disorders is extremely helpful for the elucidation of physiological processes related with complex disorders. Isolated populations are instrumental for the study of genetic disorders, considering their homogeneity and high proportion of affected patients in a small geographic area. These favorable conditions lead to the creation of a new discipline, known as "population medical genetics", which integrates medical genetics, population genetics, epidemiological genetics and community genetics. In order to develop practical activities in this new discipline, the National Institute of Population Medical Genetics (INaGeMP) was created in 2008 in Brazil. INaGeMP has developed several tools and funded numerous research activities. In this review, we highlight three successful projects developed in the first 10 years of INaGeMP activities (2008-2018): a newborn screening pilot study for MPS VI in Northeast Brazil, the study of Machado-Joseph disease in Brazilian families with Azorian ancestry, and the high twinning rate in a small town in southern Brazil. The results of these projects in terms of scientific output and contributions to the affected communities highlight the success and importance of INaGeMP. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-09-27T03:45:07Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/199807 |
dc.identifier.issn.pt_BR.fl_str_mv |
1415-4757 |
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001100682 |
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1415-4757 001100682 |
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http://hdl.handle.net/10183/199807 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Genetics and molecular biology. Ribeirão Preto. Vol. 42, n. 1, suppl. 1 (2019), p. 312-320 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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