Effect of skilled and unskilled training on nerve regeneration and functional recovery
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/100145 |
Resumo: | The most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either “skilled” (reaching for small food pellets) or “unskilled” (walking on a motorized treadmill) training. During this period, functional recovery was monitored weekly using staircase and cylinder tests. Histological and morphometric nerve analyses were used to assess nerve regeneration at the end of treatment. The functional evaluation demonstrated benefits of both tasks, but found no difference between them (P > 0.05). The unskilled training, however, induced a greater degree of nerve regeneration as evidenced by histological measurement (P < 0.05). These data provide evidence that both of the forelimb training tasks used in this study can accelerate functional recovery following brachial plexus injury. |
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Pagnussat, Aline de SouzaMichaelsen, Stella MarisAchaval-Elena, MatildeIlha, JocemarHermel, Erica do Espirito SantoBack, Franklin PanatoNetto, Carlos Alexandre2014-08-12T02:10:48Z20120100-879Xhttp://hdl.handle.net/10183/100145000929847The most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either “skilled” (reaching for small food pellets) or “unskilled” (walking on a motorized treadmill) training. During this period, functional recovery was monitored weekly using staircase and cylinder tests. Histological and morphometric nerve analyses were used to assess nerve regeneration at the end of treatment. The functional evaluation demonstrated benefits of both tasks, but found no difference between them (P > 0.05). The unskilled training, however, induced a greater degree of nerve regeneration as evidenced by histological measurement (P < 0.05). These data provide evidence that both of the forelimb training tasks used in this study can accelerate functional recovery following brachial plexus injury.application/pdfengBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 45, n. 8 (ago. 2012), p. 753-762Traumatismos dos nervos periféricosRecuperação de função fisiológicaNervo medianoNervo ulnarPeripheral nerve injuryFunctional recoveryMedian nerveUlnar nerveNerve morphometryEffect of skilled and unskilled training on nerve regeneration and functional recoveryinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000929847.pdf000929847.pdfTexto completo (inglês)application/pdf2343139http://www.lume.ufrgs.br/bitstream/10183/100145/1/000929847.pdf3d56426b79009e5f3b87ed062861d878MD51TEXT000929847.pdf.txt000929847.pdf.txtExtracted Texttext/plain40810http://www.lume.ufrgs.br/bitstream/10183/100145/2/000929847.pdf.txtdf811fea5855c164b21598147bb9f16aMD52THUMBNAIL000929847.pdf.jpg000929847.pdf.jpgGenerated Thumbnailimage/jpeg2011http://www.lume.ufrgs.br/bitstream/10183/100145/3/000929847.pdf.jpgc4fe0258a04b8401d0470acff3a4ea2eMD5310183/1001452021-11-20 05:55:26.903728oai:www.lume.ufrgs.br:10183/100145Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-11-20T07:55:26Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
title |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
spellingShingle |
Effect of skilled and unskilled training on nerve regeneration and functional recovery Pagnussat, Aline de Souza Traumatismos dos nervos periféricos Recuperação de função fisiológica Nervo mediano Nervo ulnar Peripheral nerve injury Functional recovery Median nerve Ulnar nerve Nerve morphometry |
title_short |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
title_full |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
title_fullStr |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
title_full_unstemmed |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
title_sort |
Effect of skilled and unskilled training on nerve regeneration and functional recovery |
author |
Pagnussat, Aline de Souza |
author_facet |
Pagnussat, Aline de Souza Michaelsen, Stella Maris Achaval-Elena, Matilde Ilha, Jocemar Hermel, Erica do Espirito Santo Back, Franklin Panato Netto, Carlos Alexandre |
author_role |
author |
author2 |
Michaelsen, Stella Maris Achaval-Elena, Matilde Ilha, Jocemar Hermel, Erica do Espirito Santo Back, Franklin Panato Netto, Carlos Alexandre |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Pagnussat, Aline de Souza Michaelsen, Stella Maris Achaval-Elena, Matilde Ilha, Jocemar Hermel, Erica do Espirito Santo Back, Franklin Panato Netto, Carlos Alexandre |
dc.subject.por.fl_str_mv |
Traumatismos dos nervos periféricos Recuperação de função fisiológica Nervo mediano Nervo ulnar |
topic |
Traumatismos dos nervos periféricos Recuperação de função fisiológica Nervo mediano Nervo ulnar Peripheral nerve injury Functional recovery Median nerve Ulnar nerve Nerve morphometry |
dc.subject.eng.fl_str_mv |
Peripheral nerve injury Functional recovery Median nerve Ulnar nerve Nerve morphometry |
description |
The most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either “skilled” (reaching for small food pellets) or “unskilled” (walking on a motorized treadmill) training. During this period, functional recovery was monitored weekly using staircase and cylinder tests. Histological and morphometric nerve analyses were used to assess nerve regeneration at the end of treatment. The functional evaluation demonstrated benefits of both tasks, but found no difference between them (P > 0.05). The unskilled training, however, induced a greater degree of nerve regeneration as evidenced by histological measurement (P < 0.05). These data provide evidence that both of the forelimb training tasks used in this study can accelerate functional recovery following brachial plexus injury. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
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2014-08-12T02:10:48Z |
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0100-879X |
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dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 45, n. 8 (ago. 2012), p. 753-762 |
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