TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/79653 |
Resumo: | We report a study of TGFA / Taq I polymorphisms and environmental factors in non-syndromic oral cleft in Southern Brazil. Nonsyndromic cleft case-parent triads were recruited to participate. Clinical data was collected with an emphasis on tobacco and alcohol use during pregnancy. DNA was extracted from peripheral blood and TGFA / Taq I polymorphisms were analyzed by PCR / RFLP with Taq I restriction enzyme. Association of clefts and TGFA / Taq I polymorphisms was determined using a transmission disequilibrium test (TDT). Association of environmental factors, clefts, and genotypes was evaluated with Fisher’s exact test. The minor allele frequency was 0.064. We found no evidence of association between TGFA / Taq I polymorphisms and clefting (TDT p = 0.335). We also found no association between TGFA / Taq I polymorphisms and environmental factors (alcohol and/or tobacco). Therefore, no evidence was found that TGFA / Taq I polymorphisms play a role in clefting in this population. No evidence was found that tobacco or alcohol exposure during pregnancy was related to clefting, however a larger sample size is needed to confirm these results. |
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Souza, Liliane Todeschini deKowalski, Thayne WoycinckVanz, Ana PaulaGiugliani, RobertoFelix, Temis Maria2013-10-26T01:51:09Z20121806-8324http://hdl.handle.net/10183/79653000870027We report a study of TGFA / Taq I polymorphisms and environmental factors in non-syndromic oral cleft in Southern Brazil. Nonsyndromic cleft case-parent triads were recruited to participate. Clinical data was collected with an emphasis on tobacco and alcohol use during pregnancy. DNA was extracted from peripheral blood and TGFA / Taq I polymorphisms were analyzed by PCR / RFLP with Taq I restriction enzyme. Association of clefts and TGFA / Taq I polymorphisms was determined using a transmission disequilibrium test (TDT). Association of environmental factors, clefts, and genotypes was evaluated with Fisher’s exact test. The minor allele frequency was 0.064. We found no evidence of association between TGFA / Taq I polymorphisms and clefting (TDT p = 0.335). We also found no association between TGFA / Taq I polymorphisms and environmental factors (alcohol and/or tobacco). Therefore, no evidence was found that TGFA / Taq I polymorphisms play a role in clefting in this population. No evidence was found that tobacco or alcohol exposure during pregnancy was related to clefting, however a larger sample size is needed to confirm these results.application/pdfengBrazilian oral research. São Paulo. Vol. 26, n. 5 (set./out. 2012), p. 431-435Fissura palatinaPolimorfismo genéticoBrasil, Região SulBrasilCleft lipCleft palatePolymorphismGeneticEnvironmental ExposureTGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazilinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000870027.pdf000870027.pdfTexto completo (inglês)application/pdf149004http://www.lume.ufrgs.br/bitstream/10183/79653/1/000870027.pdf964b6e080e1111142cee3688fe2870d0MD51TEXT000870027.pdf.txt000870027.pdf.txtExtracted Texttext/plain20623http://www.lume.ufrgs.br/bitstream/10183/79653/2/000870027.pdf.txt4a8bc7d1bd47080082899e717b35acffMD52THUMBNAIL000870027.pdf.jpg000870027.pdf.jpgGenerated Thumbnailimage/jpeg1799http://www.lume.ufrgs.br/bitstream/10183/79653/3/000870027.pdf.jpg3133e7dfa747a058c5251decd78701dbMD5310183/796532021-07-09 04:39:49.090242oai:www.lume.ufrgs.br:10183/79653Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2021-07-09T07:39:49Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
title |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
spellingShingle |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil Souza, Liliane Todeschini de Fissura palatina Polimorfismo genético Brasil, Região Sul Brasil Cleft lip Cleft palate Polymorphism Genetic Environmental Exposure |
title_short |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
title_full |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
title_fullStr |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
title_full_unstemmed |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
title_sort |
TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil |
author |
Souza, Liliane Todeschini de |
author_facet |
Souza, Liliane Todeschini de Kowalski, Thayne Woycinck Vanz, Ana Paula Giugliani, Roberto Felix, Temis Maria |
author_role |
author |
author2 |
Kowalski, Thayne Woycinck Vanz, Ana Paula Giugliani, Roberto Felix, Temis Maria |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Souza, Liliane Todeschini de Kowalski, Thayne Woycinck Vanz, Ana Paula Giugliani, Roberto Felix, Temis Maria |
dc.subject.por.fl_str_mv |
Fissura palatina Polimorfismo genético Brasil, Região Sul Brasil |
topic |
Fissura palatina Polimorfismo genético Brasil, Região Sul Brasil Cleft lip Cleft palate Polymorphism Genetic Environmental Exposure |
dc.subject.eng.fl_str_mv |
Cleft lip Cleft palate Polymorphism Genetic Environmental Exposure |
description |
We report a study of TGFA / Taq I polymorphisms and environmental factors in non-syndromic oral cleft in Southern Brazil. Nonsyndromic cleft case-parent triads were recruited to participate. Clinical data was collected with an emphasis on tobacco and alcohol use during pregnancy. DNA was extracted from peripheral blood and TGFA / Taq I polymorphisms were analyzed by PCR / RFLP with Taq I restriction enzyme. Association of clefts and TGFA / Taq I polymorphisms was determined using a transmission disequilibrium test (TDT). Association of environmental factors, clefts, and genotypes was evaluated with Fisher’s exact test. The minor allele frequency was 0.064. We found no evidence of association between TGFA / Taq I polymorphisms and clefting (TDT p = 0.335). We also found no association between TGFA / Taq I polymorphisms and environmental factors (alcohol and/or tobacco). Therefore, no evidence was found that TGFA / Taq I polymorphisms play a role in clefting in this population. No evidence was found that tobacco or alcohol exposure during pregnancy was related to clefting, however a larger sample size is needed to confirm these results. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2013-10-26T01:51:09Z |
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info:eu-repo/semantics/article info:eu-repo/semantics/other |
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http://hdl.handle.net/10183/79653 |
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1806-8324 |
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000870027 |
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eng |
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Brazilian oral research. São Paulo. Vol. 26, n. 5 (set./out. 2012), p. 431-435 |
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openAccess |
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