Glycated albumin: a potential biomarker in diabetes
Main Author: | |
---|---|
Publication Date: | 2017 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UFRGS |
Download full: | http://hdl.handle.net/10183/211566 |
Summary: | Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform. These laboratory characteristics have ensured the highlight of GA in studies from the last decade, as a marker of monitoring and screening for DM, as well as a predictor of long-term outcomes of the disease. The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM. |
id |
UFRGS-2_b02a401d1210287d5a61b70188d16657 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/211566 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Freitas, Priscila Aparecida CorreaEhlert, Lethicia RozalesCamargo, Joiza Lins2020-07-09T03:41:18Z20172359-4292http://hdl.handle.net/10183/211566001114926Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform. These laboratory characteristics have ensured the highlight of GA in studies from the last decade, as a marker of monitoring and screening for DM, as well as a predictor of long-term outcomes of the disease. The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM.application/pdfengArchives of endocrinology and metabolism. São Paulo. Vol. 61, n. 3 (2017), p. 296-304Diabetes mellitus tipo 2Albumina séricaHemoglobinas glicadasGlucoseBiomarcadoresRevisãoDiabetes mellitusGlycated albuminGlycated proteinsGlycated albumin: a potential biomarker in diabetesinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSTEXT001114926.pdf.txt001114926.pdf.txtExtracted Texttext/plain43243http://www.lume.ufrgs.br/bitstream/10183/211566/2/001114926.pdf.txt0256bf74f7f3e388f956d40e8caa5241MD52ORIGINAL001114926.pdfTexto completo (inglês)application/pdf156276http://www.lume.ufrgs.br/bitstream/10183/211566/1/001114926.pdf835d32cec8ca34e8d1296f1fa218cc20MD5110183/2115662023-11-18 04:25:14.98114oai:www.lume.ufrgs.br:10183/211566Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-11-18T06:25:14Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Glycated albumin: a potential biomarker in diabetes |
title |
Glycated albumin: a potential biomarker in diabetes |
spellingShingle |
Glycated albumin: a potential biomarker in diabetes Freitas, Priscila Aparecida Correa Diabetes mellitus tipo 2 Albumina sérica Hemoglobinas glicadas Glucose Biomarcadores Revisão Diabetes mellitus Glycated albumin Glycated proteins |
title_short |
Glycated albumin: a potential biomarker in diabetes |
title_full |
Glycated albumin: a potential biomarker in diabetes |
title_fullStr |
Glycated albumin: a potential biomarker in diabetes |
title_full_unstemmed |
Glycated albumin: a potential biomarker in diabetes |
title_sort |
Glycated albumin: a potential biomarker in diabetes |
author |
Freitas, Priscila Aparecida Correa |
author_facet |
Freitas, Priscila Aparecida Correa Ehlert, Lethicia Rozales Camargo, Joiza Lins |
author_role |
author |
author2 |
Ehlert, Lethicia Rozales Camargo, Joiza Lins |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Freitas, Priscila Aparecida Correa Ehlert, Lethicia Rozales Camargo, Joiza Lins |
dc.subject.por.fl_str_mv |
Diabetes mellitus tipo 2 Albumina sérica Hemoglobinas glicadas Glucose Biomarcadores Revisão |
topic |
Diabetes mellitus tipo 2 Albumina sérica Hemoglobinas glicadas Glucose Biomarcadores Revisão Diabetes mellitus Glycated albumin Glycated proteins |
dc.subject.eng.fl_str_mv |
Diabetes mellitus Glycated albumin Glycated proteins |
description |
Diabetes mellitus (DM) is a chronic and metabolic disease that presents a high global incidence. Glycated hemoglobin (A1C) is the reference test for long-term glucose monitoring, and it exhibits an association with diabetic chronic complications. However, A1C is not recommended in clinical situations which may interfere with the metabolism of hemoglobin, such as in hemolytic, secondary or iron deficiency anemia, hemoglobinopathies, pregnancy, and uremia. The glycated albumin (GA) is a test that reflects short-term glycemia and is not influenced by situations that falsely alter A1C levels. GA is the higher glycated portion of fructosamine. It is measured by a standardized enzymatic methodology, easy and fast to perform. These laboratory characteristics have ensured the highlight of GA in studies from the last decade, as a marker of monitoring and screening for DM, as well as a predictor of long-term outcomes of the disease. The aim of this review was to discuss the physiological and biochemistry characteristics of the GA, as well as its clinical utility in DM. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-09T03:41:18Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/211566 |
dc.identifier.issn.pt_BR.fl_str_mv |
2359-4292 |
dc.identifier.nrb.pt_BR.fl_str_mv |
001114926 |
identifier_str_mv |
2359-4292 001114926 |
url |
http://hdl.handle.net/10183/211566 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Archives of endocrinology and metabolism. São Paulo. Vol. 61, n. 3 (2017), p. 296-304 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/211566/2/001114926.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/211566/1/001114926.pdf |
bitstream.checksum.fl_str_mv |
0256bf74f7f3e388f956d40e8caa5241 835d32cec8ca34e8d1296f1fa218cc20 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1798487437379371008 |