Assessment of regulatory T cells in childhood immune thrombocytopenic purpura
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/96817 |
Resumo: | This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP—whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis—and 19 healthy controls. Tregs (CD4+ CD25+Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups.The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP. |
id |
UFRGS-2_da1a0f57fbe8b4d430ba21d85b45cee1 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/96817 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Mazzucco, Karina Lorenzi MarramarcoMoraes Júnior, LauroLemos, Natália EmerimWieck, AndreaPezzi, AnneliseLaureano, Álvaro MacedoAmorin, BrunaValim, Vanessa de SouzaSilla, Lucia Mariano da RochaDaudt, Liane EstevesMarostica, Paulo José Cauduro2014-06-21T02:07:33Z20132090-4428http://hdl.handle.net/10183/96817000914105This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP—whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis—and 19 healthy controls. Tregs (CD4+ CD25+Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups.The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP.application/pdfengISRN hematology. Cairo. Vol. 2013 (Nov. 2013), artigo ID 143687, [5] p.Púrpura trombocitopênica idiopáticaCriançaLinfócitos TAssessment of regulatory T cells in childhood immune thrombocytopenic purpuraEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000914105.pdf000914105.pdfTexto completo (inglês)application/pdf478822http://www.lume.ufrgs.br/bitstream/10183/96817/1/000914105.pdf9bad38ac968273651a637fd0280a87cbMD51TEXT000914105.pdf.txt000914105.pdf.txtExtracted Texttext/plain22795http://www.lume.ufrgs.br/bitstream/10183/96817/2/000914105.pdf.txt11b59d80bd48f9d88c276c7d91ce5721MD52THUMBNAIL000914105.pdf.jpg000914105.pdf.jpgGenerated Thumbnailimage/jpeg1942http://www.lume.ufrgs.br/bitstream/10183/96817/3/000914105.pdf.jpg06ce85c411216a92ebe72e87ffbc55cdMD5310183/968172018-10-18 08:32:03.894oai:www.lume.ufrgs.br:10183/96817Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-18T11:32:03Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
title |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
spellingShingle |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura Mazzucco, Karina Lorenzi Marramarco Púrpura trombocitopênica idiopática Criança Linfócitos T |
title_short |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
title_full |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
title_fullStr |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
title_full_unstemmed |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
title_sort |
Assessment of regulatory T cells in childhood immune thrombocytopenic purpura |
author |
Mazzucco, Karina Lorenzi Marramarco |
author_facet |
Mazzucco, Karina Lorenzi Marramarco Moraes Júnior, Lauro Lemos, Natália Emerim Wieck, Andrea Pezzi, Annelise Laureano, Álvaro Macedo Amorin, Bruna Valim, Vanessa de Souza Silla, Lucia Mariano da Rocha Daudt, Liane Esteves Marostica, Paulo José Cauduro |
author_role |
author |
author2 |
Moraes Júnior, Lauro Lemos, Natália Emerim Wieck, Andrea Pezzi, Annelise Laureano, Álvaro Macedo Amorin, Bruna Valim, Vanessa de Souza Silla, Lucia Mariano da Rocha Daudt, Liane Esteves Marostica, Paulo José Cauduro |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mazzucco, Karina Lorenzi Marramarco Moraes Júnior, Lauro Lemos, Natália Emerim Wieck, Andrea Pezzi, Annelise Laureano, Álvaro Macedo Amorin, Bruna Valim, Vanessa de Souza Silla, Lucia Mariano da Rocha Daudt, Liane Esteves Marostica, Paulo José Cauduro |
dc.subject.por.fl_str_mv |
Púrpura trombocitopênica idiopática Criança Linfócitos T |
topic |
Púrpura trombocitopênica idiopática Criança Linfócitos T |
description |
This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP—whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis—and 19 healthy controls. Tregs (CD4+ CD25+Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups.The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013 |
dc.date.accessioned.fl_str_mv |
2014-06-21T02:07:33Z |
dc.type.driver.fl_str_mv |
Estrangeiro info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/96817 |
dc.identifier.issn.pt_BR.fl_str_mv |
2090-4428 |
dc.identifier.nrb.pt_BR.fl_str_mv |
000914105 |
identifier_str_mv |
2090-4428 000914105 |
url |
http://hdl.handle.net/10183/96817 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
ISRN hematology. Cairo. Vol. 2013 (Nov. 2013), artigo ID 143687, [5] p. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/96817/1/000914105.pdf http://www.lume.ufrgs.br/bitstream/10183/96817/2/000914105.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/96817/3/000914105.pdf.jpg |
bitstream.checksum.fl_str_mv |
9bad38ac968273651a637fd0280a87cb 11b59d80bd48f9d88c276c7d91ce5721 06ce85c411216a92ebe72e87ffbc55cd |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1798487243337236480 |