Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Detalhes bibliográficos
Autor(a) principal: Hoskin, Roberta Targino
Data de Publicação: 2021
Outros Autores: Pambianchi, Erika, Pecorelli, Alessandra, Grace, Mary Halim, Therrien, Jean-Philippe, Valacchi, Giuseppe, Lila, Mary Ann
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/45376
Resumo: The present study investigated the effect of spray-dried algae-rosemary particles against pollution-induced damage using ex-vivo human biopsies exposed to diesel engine exhaust (DEE). For this, the complexation of hydroalcoholic rosemary extract with Chlorella (RCH) and Spirulina (RSP) protein powders was conducted. The process efficiency and concentration of rosmarinic acid (RA), carnosic acid (CA), and carnosol (CR) phenolic compounds of both products were compared. The RSP spray-dried production was more efficient, and RSP particles presented higher CR and CA and similar RA concentrations. Therefore, spray-dried RSP particles were prioritized for the preparation of a gel formulation that was investigated for its ability to mitigate pollution-induced skin oxinflammatory responses. Taken altogether, our ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts (4HNE-PA) and active matrix metalloproteinase-9 (MMP-9) as well as by limiting the loss of filaggrin induced by DEE exposure. Our results suggest that the topical application of spirulina-rosemary gel is a good approach to prevent pollution-induced skin aging/damage
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spelling Hoskin, Roberta TarginoPambianchi, ErikaPecorelli, AlessandraGrace, Mary HalimTherrien, Jean-PhilippeValacchi, GiuseppeLila, Mary Ann2021-12-15T14:20:32Z2021-12-15T14:20:32Z2021Roberta Correia; PAMBIANCHI, E.; PECORELLI, A.; GRACE, MARY H.; THERRIEN, J.; VALACCHI, G.; LILA, MARY ANN. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. MOLECULES, v. 26, p. 3781, 2021. Disponível em: https://www.mdpi.com/1420-3049/26/13/3781. Acesso em: 04 nov. 2021. https://doi.org/10.3390/molecules261337811420-3049https://repositorio.ufrn.br/handle/123456789/4537610.3390/molecules26133781MDPIAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCosmeceuticalsPollutionPhytochemicalsHerbsNovel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damageinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe present study investigated the effect of spray-dried algae-rosemary particles against pollution-induced damage using ex-vivo human biopsies exposed to diesel engine exhaust (DEE). For this, the complexation of hydroalcoholic rosemary extract with Chlorella (RCH) and Spirulina (RSP) protein powders was conducted. The process efficiency and concentration of rosmarinic acid (RA), carnosic acid (CA), and carnosol (CR) phenolic compounds of both products were compared. The RSP spray-dried production was more efficient, and RSP particles presented higher CR and CA and similar RA concentrations. Therefore, spray-dried RSP particles were prioritized for the preparation of a gel formulation that was investigated for its ability to mitigate pollution-induced skin oxinflammatory responses. Taken altogether, our ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts (4HNE-PA) and active matrix metalloproteinase-9 (MMP-9) as well as by limiting the loss of filaggrin induced by DEE exposure. Our results suggest that the topical application of spirulina-rosemary gel is a good approach to prevent pollution-induced skin aging/damageengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALNovelSprayDried_HOSKIN_2021.pdfNovelSprayDried_HOSKIN_2021.pdfapplication/pdf4302216https://repositorio.ufrn.br/bitstream/123456789/45376/1/NovelSprayDried_HOSKIN_2021.pdf51fdeb9ae2f8d754e6c8e5b0f82557ebMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/45376/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/45376/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/453762021-12-16 09:56:27.031oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-12-16T12:56:27Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
title Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
spellingShingle Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
Hoskin, Roberta Targino
Cosmeceuticals
Pollution
Phytochemicals
Herbs
title_short Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
title_full Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
title_fullStr Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
title_full_unstemmed Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
title_sort Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage
author Hoskin, Roberta Targino
author_facet Hoskin, Roberta Targino
Pambianchi, Erika
Pecorelli, Alessandra
Grace, Mary Halim
Therrien, Jean-Philippe
Valacchi, Giuseppe
Lila, Mary Ann
author_role author
author2 Pambianchi, Erika
Pecorelli, Alessandra
Grace, Mary Halim
Therrien, Jean-Philippe
Valacchi, Giuseppe
Lila, Mary Ann
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hoskin, Roberta Targino
Pambianchi, Erika
Pecorelli, Alessandra
Grace, Mary Halim
Therrien, Jean-Philippe
Valacchi, Giuseppe
Lila, Mary Ann
dc.subject.por.fl_str_mv Cosmeceuticals
Pollution
Phytochemicals
Herbs
topic Cosmeceuticals
Pollution
Phytochemicals
Herbs
description The present study investigated the effect of spray-dried algae-rosemary particles against pollution-induced damage using ex-vivo human biopsies exposed to diesel engine exhaust (DEE). For this, the complexation of hydroalcoholic rosemary extract with Chlorella (RCH) and Spirulina (RSP) protein powders was conducted. The process efficiency and concentration of rosmarinic acid (RA), carnosic acid (CA), and carnosol (CR) phenolic compounds of both products were compared. The RSP spray-dried production was more efficient, and RSP particles presented higher CR and CA and similar RA concentrations. Therefore, spray-dried RSP particles were prioritized for the preparation of a gel formulation that was investigated for its ability to mitigate pollution-induced skin oxinflammatory responses. Taken altogether, our ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts (4HNE-PA) and active matrix metalloproteinase-9 (MMP-9) as well as by limiting the loss of filaggrin induced by DEE exposure. Our results suggest that the topical application of spirulina-rosemary gel is a good approach to prevent pollution-induced skin aging/damage
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-15T14:20:32Z
dc.date.available.fl_str_mv 2021-12-15T14:20:32Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Roberta Correia; PAMBIANCHI, E.; PECORELLI, A.; GRACE, MARY H.; THERRIEN, J.; VALACCHI, G.; LILA, MARY ANN. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. MOLECULES, v. 26, p. 3781, 2021. Disponível em: https://www.mdpi.com/1420-3049/26/13/3781. Acesso em: 04 nov. 2021. https://doi.org/10.3390/molecules26133781
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/45376
dc.identifier.issn.none.fl_str_mv 1420-3049
dc.identifier.doi.none.fl_str_mv 10.3390/molecules26133781
identifier_str_mv Roberta Correia; PAMBIANCHI, E.; PECORELLI, A.; GRACE, MARY H.; THERRIEN, J.; VALACCHI, G.; LILA, MARY ANN. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. MOLECULES, v. 26, p. 3781, 2021. Disponível em: https://www.mdpi.com/1420-3049/26/13/3781. Acesso em: 04 nov. 2021. https://doi.org/10.3390/molecules26133781
1420-3049
10.3390/molecules26133781
url https://repositorio.ufrn.br/handle/123456789/45376
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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instname:Universidade Federal do Rio Grande do Norte (UFRN)
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