Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/53243 https://doi.org/10.1080/14756366.2022.2039918 |
Resumo: | This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health. |
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Morais, Ana Heloneida de AraujoNascimento, Amanda Maria de SouzaOliveira Segundo, Victor Hugo deAguiar, Ana Julia Felipe CameloPiuvezam, GrasielaPassos, Tha ıs SouzaDamasceno, Karla Suzanne Florentino da Silva Chaveshttp://lattes.cnpq.br/12339444933346512023-07-11T20:49:33Z2023-07-11T20:49:33Z2022NASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2039918. Acesso em: 11 jul. 2023.https://repositorio.ufrn.br/handle/123456789/53243https://doi.org/10.1080/14756366.2022.2039918Taylor & FrancisAntimicrobial peptidesbioactive proteinsinfectious diseasesbacteriaAntibacterial action mechanisms and mode of trypsin inhibitors: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThis systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALAntibacterialactionmechanisms_Nascimento_2022.pdfAntibacterialactionmechanisms_Nascimento_2022.pdfapplication/pdf2045614https://repositorio.ufrn.br/bitstream/123456789/53243/1/Antibacterialactionmechanisms_Nascimento_2022.pdf265ce0ea9278b04dac1e3a5bbdfc535dMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/53243/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/532432023-11-07 15:54:05.924oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-11-07T18:54:05Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
title |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
spellingShingle |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review Morais, Ana Heloneida de Araujo Antimicrobial peptides bioactive proteins infectious diseases bacteria |
title_short |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
title_full |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
title_fullStr |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
title_full_unstemmed |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
title_sort |
Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review |
author |
Morais, Ana Heloneida de Araujo |
author_facet |
Morais, Ana Heloneida de Araujo Nascimento, Amanda Maria de Souza Oliveira Segundo, Victor Hugo de Aguiar, Ana Julia Felipe Camelo Piuvezam, Grasiela Passos, Tha ıs Souza Damasceno, Karla Suzanne Florentino da Silva Chaves |
author_role |
author |
author2 |
Nascimento, Amanda Maria de Souza Oliveira Segundo, Victor Hugo de Aguiar, Ana Julia Felipe Camelo Piuvezam, Grasiela Passos, Tha ıs Souza Damasceno, Karla Suzanne Florentino da Silva Chaves |
author2_role |
author author author author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
http://lattes.cnpq.br/1233944493334651 |
dc.contributor.author.fl_str_mv |
Morais, Ana Heloneida de Araujo Nascimento, Amanda Maria de Souza Oliveira Segundo, Victor Hugo de Aguiar, Ana Julia Felipe Camelo Piuvezam, Grasiela Passos, Tha ıs Souza Damasceno, Karla Suzanne Florentino da Silva Chaves |
dc.subject.por.fl_str_mv |
Antimicrobial peptides bioactive proteins infectious diseases bacteria |
topic |
Antimicrobial peptides bioactive proteins infectious diseases bacteria |
description |
This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibac terial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demon strated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous pro teases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health. |
publishDate |
2022 |
dc.date.issued.fl_str_mv |
2022 |
dc.date.accessioned.fl_str_mv |
2023-07-11T20:49:33Z |
dc.date.available.fl_str_mv |
2023-07-11T20:49:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2039918. Acesso em: 11 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/53243 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1080/14756366.2022.2039918 |
identifier_str_mv |
NASCIMENTO, Amanda Maria de Souza et al. Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. Journal of Enzyme Inhibition and Medicinal Chemistry, v. 37, n. 1, p. 749-759, 2022. Disponível em: https://www.tandfonline.com/doi/full/10.1080/14756366.2022.2039918. Acesso em: 11 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/53243 https://doi.org/10.1080/14756366.2022.2039918 |
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eng |
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eng |
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openAccess |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
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Taylor & Francis |
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