Bioassay-guided evaluation of central nervous system effects of citronellal in rodents

• Autor(a) principal: Melo, Mônica Santos de
• Data de Publicação: 2011
• Outros Autores: Souza, Marilia Trindade de Santana, Guimarães, Adriana Gibara, Barreto, Rosana de Souza Siqueira, Quintans-Júnior, Lucindo José, Santos, Márcio Roberto Viana dos, Bonjardim, Leonardo Rigoldi, Araújo, Adriano Antunes de Souza, Onofre, Alexandre Sherlley Casimiro, Lima, Julianeli Tolentino de, Almeida, Jackson Roberto Guedes da Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFS
• Texto Completo: https://ri.ufs.br/handle/riufs/589
• topic: Atividade anticonvulsivante; Citronela; Monoterpenos; Atividade depressora

The central nervous system (CNS) depressant and anticonvulsant activities of citronellal (CT) were investigated in animal models. The CT in doses of 100, 200 and 400 mg/kg injected by i.p. route in mice caused a significant decrease in the motor activity of animals when compared with the control group. The highest dose of CT significantly reduced the remaining time of the animals on the Rota-rod apparatus up to 2 h. Additionally, CT at doses 100, 200 and 400 mg/ kg (i.p.) was also capable to promote an increase of latency for development of convulsions induced by pentylenetetrazole (PTZ). It was efficient in prevents the tonic convulsions induced by maximal electroshock (MES) in doses of 200 and 400 mg/kg, resulting in 30 and 40% of protection, respectively. This compound was also capable to promote an increase of latency for development of convulsions induced by picrotoxin (PIC) at 400 mg/kg. In the same way, the anticonvulsant effect of CT was affected by pretreatment with flumazenil, a selective antagonist of benzodiazepine site of GABAA receptor. These results suggest a possible CNS depressant and anticonvulsant activities.