Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35988 http://dx.doi.org/10.1002/oby.20063 |
Resumo: | Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages.Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered.Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity).Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure. |
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Tenório, Neuli Maria [UNIFESP]Tufik, Sergio [UNIFESP]Bergamaschi, Cassia Toledo [UNIFESP]Campos, Ruy Ribeiro [UNIFESP]Cintra, Fátima Dumas [UNIFESP]Alvarenga, Tathiana Aparecida [UNIFESP]Andersen, Monica Levy [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:31:16Z2016-01-24T14:31:16Z2013-03-01Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 3, p. 510-515, 2013.1930-7381http://repositorio.unifesp.br/handle/11600/35988http://dx.doi.org/10.1002/oby.2006310.1002/oby.20063WOS:000322087600038Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages.Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered.Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity).Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure.Associacao Fundo de Incentivo a Pesquisa (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Fisiol, São Paulo, BrazilFAPESP: 98/14303-3Web of Science510-515engWiley-BlackwellObesityhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessInfluence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/359882021-09-30 17:26:56.621metadata only accessoai:repositorio.unifesp.br:11600/35988Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:40.939117Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
title |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
spellingShingle |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats Tenório, Neuli Maria [UNIFESP] |
title_short |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
title_full |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
title_fullStr |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
title_full_unstemmed |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
title_sort |
Influence of Acute Sleep Deprivation on Cardiovascular Parameters in Female Zucker Obese and Lean Rats |
author |
Tenório, Neuli Maria [UNIFESP] |
author_facet |
Tenório, Neuli Maria [UNIFESP] Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Alvarenga, Tathiana Aparecida [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author_role |
author |
author2 |
Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Alvarenga, Tathiana Aparecida [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Tenório, Neuli Maria [UNIFESP] Tufik, Sergio [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Alvarenga, Tathiana Aparecida [UNIFESP] Andersen, Monica Levy [UNIFESP] |
description |
Objective: There is a reciprocal relationship between sleep duration and weight gain. However, the consequences of this relationship on the cardiovascular system over an entire life span are still not fully elucidated. We examined the effect of acute sleep deprivation (SD) on baroreflex sensitivity and blood pressure in Zucker rats of different ages.Design and Methods: Female lean and obese Zucker rats at 3, 6 and 15 months of age were assigned to SD or control (CTRL) groups. After a 6 h period of the SD procedure (6 h of gentle handling) or CTRL procedure (an equivalent period without handling), the animals were anesthetized for surgical catheterization of the femoral artery and vein. To evaluate the baroreflex sensitivity index, bolus infusions of phenylephrine (bradycardia response) and sodium nitroprusside (tachycardia response) were administered.Results: Obesity resulted in dysfunctional tachycardia responses at 3 months of age. At 6 and 15 months of age, both bradycardia and tachycardia responses were significantly lower in obese animals than those in lean animals. At 15 months of age, interactions among obesity, SD and aging produced the most marked effects on the cardiovascular system (increased mean arterial pressure and heart rate and decreased baroreflex sensitivity).Conclusions: Therefore, these results suggest that there is no direct relationship between baroreflex imbalance and an increase in arterial pressure. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:16Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:16Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 3, p. 510-515, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35988 http://dx.doi.org/10.1002/oby.20063 |
dc.identifier.issn.none.fl_str_mv |
1930-7381 |
dc.identifier.doi.none.fl_str_mv |
10.1002/oby.20063 |
dc.identifier.wos.none.fl_str_mv |
WOS:000322087600038 |
identifier_str_mv |
Obesity. Hoboken: Wiley-Blackwell, v. 21, n. 3, p. 510-515, 2013. 1930-7381 10.1002/oby.20063 WOS:000322087600038 |
url |
http://repositorio.unifesp.br/handle/11600/35988 http://dx.doi.org/10.1002/oby.20063 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Obesity |
dc.rights.driver.fl_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
510-515 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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