Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy

Detalhes bibliográficos
Autor(a) principal: Perosa, Sandra Regina [UNIFESP]
Data de Publicação: 2002
Outros Autores: Porcionatto, Marimélia Aparecida [UNIFESP], Cukiert, A., Martins, João Roberto Maciel [UNIFESP], Amado, Débora [UNIFESP], Nader, Helena Bonciani [UNIFESP], Leite, J. P., Naffah-Mazzacoratti, Maria da Graca [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/26682
http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x
Resumo: Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
id UFSP_1998b6f8c3295d5a34dc744b2bf3f363
oai_identifier_str oai:repositorio.unifesp.br:11600/26682
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Perosa, Sandra Regina [UNIFESP]Porcionatto, Marimélia Aparecida [UNIFESP]Cukiert, A.Martins, João Roberto Maciel [UNIFESP]Amado, Débora [UNIFESP]Nader, Helena Bonciani [UNIFESP]Leite, J. P.Naffah-Mazzacoratti, Maria da Graca [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Hosp BrigadeiroUniversidade de São Paulo (USP)2016-01-24T12:33:09Z2016-01-24T12:33:09Z2002-01-01Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.0013-9580http://repositorio.unifesp.br/handle/11600/26682http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x10.1046/j.1528-1157.43.s.5.30.xWOS:000177445900029Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.Universidade Federal de São Paulo, Dept Bioquim, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Neurol Expt, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Biol Mol, BR-04023900 São Paulo, BrazilHosp Brigadeiro, São Paulo, BrazilFMRPUSP, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Bioquim, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Neurol Expt, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Biol Mol, BR-04023900 São Paulo, BrazilWeb of Science159-161engBlackwell Publishing IncEpilepsiachondroitin sulfateheparan sulfatehyaluronic acidtemporal lobe epilepsyExtracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/266822023-02-15 11:39:37.871metadata only accessoai:repositorio.unifesp.br:11600/26682Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:54.775986Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
title Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
spellingShingle Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
Perosa, Sandra Regina [UNIFESP]
chondroitin sulfate
heparan sulfate
hyaluronic acid
temporal lobe epilepsy
title_short Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
title_full Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
title_fullStr Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
title_full_unstemmed Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
title_sort Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
author Perosa, Sandra Regina [UNIFESP]
author_facet Perosa, Sandra Regina [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Cukiert, A.
Martins, João Roberto Maciel [UNIFESP]
Amado, Débora [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Leite, J. P.
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author_role author
author2 Porcionatto, Marimélia Aparecida [UNIFESP]
Cukiert, A.
Martins, João Roberto Maciel [UNIFESP]
Amado, Débora [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Leite, J. P.
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hosp Brigadeiro
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Perosa, Sandra Regina [UNIFESP]
Porcionatto, Marimélia Aparecida [UNIFESP]
Cukiert, A.
Martins, João Roberto Maciel [UNIFESP]
Amado, Débora [UNIFESP]
Nader, Helena Bonciani [UNIFESP]
Leite, J. P.
Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Cavalheiro, Esper Abrão [UNIFESP]
dc.subject.eng.fl_str_mv chondroitin sulfate
heparan sulfate
hyaluronic acid
temporal lobe epilepsy
topic chondroitin sulfate
heparan sulfate
hyaluronic acid
temporal lobe epilepsy
description Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.
publishDate 2002
dc.date.issued.fl_str_mv 2002-01-01
dc.date.accessioned.fl_str_mv 2016-01-24T12:33:09Z
dc.date.available.fl_str_mv 2016-01-24T12:33:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/26682
http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x
dc.identifier.issn.none.fl_str_mv 0013-9580
dc.identifier.doi.none.fl_str_mv 10.1046/j.1528-1157.43.s.5.30.x
dc.identifier.wos.none.fl_str_mv WOS:000177445900029
identifier_str_mv Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.
0013-9580
10.1046/j.1528-1157.43.s.5.30.x
WOS:000177445900029
url http://repositorio.unifesp.br/handle/11600/26682
http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Epilepsia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 159-161
dc.publisher.none.fl_str_mv Blackwell Publishing Inc
publisher.none.fl_str_mv Blackwell Publishing Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1783460303279751168

Registros relacionados