Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy
Main Author: | |
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Publication Date: | 2002 |
Other Authors: | , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/26682 http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x |
Summary: | Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE. |
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Perosa, Sandra Regina [UNIFESP]Porcionatto, Marimélia Aparecida [UNIFESP]Cukiert, A.Martins, João Roberto Maciel [UNIFESP]Amado, Débora [UNIFESP]Nader, Helena Bonciani [UNIFESP]Leite, J. P.Naffah-Mazzacoratti, Maria da Graca [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Hosp BrigadeiroUniversidade de São Paulo (USP)2016-01-24T12:33:09Z2016-01-24T12:33:09Z2002-01-01Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002.0013-9580http://repositorio.unifesp.br/handle/11600/26682http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x10.1046/j.1528-1157.43.s.5.30.xWOS:000177445900029Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE.Universidade Federal de São Paulo, Dept Bioquim, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Neurol Expt, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Biol Mol, BR-04023900 São Paulo, BrazilHosp Brigadeiro, São Paulo, BrazilFMRPUSP, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Bioquim, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Neurol Expt, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplinas Biol Mol, BR-04023900 São Paulo, BrazilWeb of Science159-161engBlackwell Publishing IncEpilepsiachondroitin sulfateheparan sulfatehyaluronic acidtemporal lobe epilepsyExtracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/266822023-02-15 11:39:37.871metadata only accessoai:repositorio.unifesp.br:11600/26682Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:54.775986Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
title |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
spellingShingle |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy Perosa, Sandra Regina [UNIFESP] chondroitin sulfate heparan sulfate hyaluronic acid temporal lobe epilepsy |
title_short |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
title_full |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
title_fullStr |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
title_full_unstemmed |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
title_sort |
Extracellular matrix components are altered in the hippocampus, cortex, and cerebrospinal fluid of patients with mesial temporal lobe epilepsy |
author |
Perosa, Sandra Regina [UNIFESP] |
author_facet |
Perosa, Sandra Regina [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Cukiert, A. Martins, João Roberto Maciel [UNIFESP] Amado, Débora [UNIFESP] Nader, Helena Bonciani [UNIFESP] Leite, J. P. Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
author_role |
author |
author2 |
Porcionatto, Marimélia Aparecida [UNIFESP] Cukiert, A. Martins, João Roberto Maciel [UNIFESP] Amado, Débora [UNIFESP] Nader, Helena Bonciani [UNIFESP] Leite, J. P. Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Hosp Brigadeiro Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Perosa, Sandra Regina [UNIFESP] Porcionatto, Marimélia Aparecida [UNIFESP] Cukiert, A. Martins, João Roberto Maciel [UNIFESP] Amado, Débora [UNIFESP] Nader, Helena Bonciani [UNIFESP] Leite, J. P. Naffah-Mazzacoratti, Maria da Graca [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
dc.subject.eng.fl_str_mv |
chondroitin sulfate heparan sulfate hyaluronic acid temporal lobe epilepsy |
topic |
chondroitin sulfate heparan sulfate hyaluronic acid temporal lobe epilepsy |
description |
Purpose: This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE).Methods: the GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA).Results: the hippocampus of TLE patients showed increased levels of chondroitin sulfate and hyaluronic acid against normal levels of these GAGs in the neocortex and cerebrospinal fluid (CSF).Conclusions: These results suggest that these matrix components could be involved in the pathophysiology of TLE. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:33:09Z |
dc.date.available.fl_str_mv |
2016-01-24T12:33:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/26682 http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x |
dc.identifier.issn.none.fl_str_mv |
0013-9580 |
dc.identifier.doi.none.fl_str_mv |
10.1046/j.1528-1157.43.s.5.30.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000177445900029 |
identifier_str_mv |
Epilepsia. Malden: Blackwell Publishing Inc, v. 43, p. 159-161, 2002. 0013-9580 10.1046/j.1528-1157.43.s.5.30.x WOS:000177445900029 |
url |
http://repositorio.unifesp.br/handle/11600/26682 http://dx.doi.org/10.1046/j.1528-1157.43.s.5.30.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Epilepsia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
159-161 |
dc.publisher.none.fl_str_mv |
Blackwell Publishing Inc |
publisher.none.fl_str_mv |
Blackwell Publishing Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460303279751168 |