Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/28690 http://dx.doi.org/10.1016/j.maturitas.2005.02.009 |
Resumo: | Objective: the aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.Methods: It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two treatment groups: isoflavone (n = 40): 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone (60 mg twice a day), or estrogen (n = 39): one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg (placebo).Results: After treatment, there was a decrease in the symptomatology in both estrogen and isoflavone groups. There was a significant decrease in vaginal pH, an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group, but no differences were observed in the isoflavone group for these variables.Conclusions: We concluded that the daily standardized soy extract with 120 mg isoflavones' effect on symptoms was similar to that from estrogen. Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
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Kaari, Cristina [UNIFESP]Haidar, Mauro Abi [UNIFESP]Soares Junior, Jose Maria [UNIFESP]Nunes, Marcia Gaspar [UNIFESP]Quadros, Luis Gerk de Azevedo [UNIFESP]Kemp, Claudio [UNIFESP]Stavale, Joao NorbertoBaracat, Edmund Chada [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:40:54Z2016-01-24T12:40:54Z2006-01-10Maturitas. Clare: Elsevier B.V., v. 53, n. 1, p. 49-58, 2006.0378-5122http://repositorio.unifesp.br/handle/11600/28690http://dx.doi.org/10.1016/j.maturitas.2005.02.00910.1016/j.maturitas.2005.02.009WOS:000234640100007Objective: the aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.Methods: It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two treatment groups: isoflavone (n = 40): 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone (60 mg twice a day), or estrogen (n = 39): one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg (placebo).Results: After treatment, there was a decrease in the symptomatology in both estrogen and isoflavone groups. There was a significant decrease in vaginal pH, an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group, but no differences were observed in the isoflavone group for these variables.Conclusions: We concluded that the daily standardized soy extract with 120 mg isoflavones' effect on symptoms was similar to that from estrogen. Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved.Universidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04513031 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Gynecol, BR-04513031 São Paulo, BrazilWeb of Science49-58engElsevier B.V.Maturitashttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessisoflavonepostmenopausal womenhormone therapyRandomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/286902023-01-30 22:19:12.636metadata only accessoai:repositorio.unifesp.br:11600/28690Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:45:10.172219Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
title |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
spellingShingle |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study Kaari, Cristina [UNIFESP] isoflavone postmenopausal women hormone therapy |
title_short |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
title_full |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
title_fullStr |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
title_full_unstemmed |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
title_sort |
Randomized clinical trial comparing conjugated equine estrogens and isoflavones in postmenopausal women: a pilot study |
author |
Kaari, Cristina [UNIFESP] |
author_facet |
Kaari, Cristina [UNIFESP] Haidar, Mauro Abi [UNIFESP] Soares Junior, Jose Maria [UNIFESP] Nunes, Marcia Gaspar [UNIFESP] Quadros, Luis Gerk de Azevedo [UNIFESP] Kemp, Claudio [UNIFESP] Stavale, Joao Norberto Baracat, Edmund Chada [UNIFESP] |
author_role |
author |
author2 |
Haidar, Mauro Abi [UNIFESP] Soares Junior, Jose Maria [UNIFESP] Nunes, Marcia Gaspar [UNIFESP] Quadros, Luis Gerk de Azevedo [UNIFESP] Kemp, Claudio [UNIFESP] Stavale, Joao Norberto Baracat, Edmund Chada [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Kaari, Cristina [UNIFESP] Haidar, Mauro Abi [UNIFESP] Soares Junior, Jose Maria [UNIFESP] Nunes, Marcia Gaspar [UNIFESP] Quadros, Luis Gerk de Azevedo [UNIFESP] Kemp, Claudio [UNIFESP] Stavale, Joao Norberto Baracat, Edmund Chada [UNIFESP] |
dc.subject.eng.fl_str_mv |
isoflavone postmenopausal women hormone therapy |
topic |
isoflavone postmenopausal women hormone therapy |
description |
Objective: the aim of this study was to evaluate the effects of isoflavone on the climacteric symptoms (Kupperman Menopausal index), vaginal pH, vaginal cytology (vaginal maturation index) and endometrium (evaluated by ultrasound and biopsy) in postmenopausal women.Methods: It was a single-center, 6-month, randomized, double-blind, estrogen-controlled trial. Seventy-nine women were randomly assigned to one of the two treatment groups: isoflavone (n = 40): 300 mg of the standardized soy extract with a medium dose of 120 mg isoflavones/day as glycoside and aglycone (60 mg twice a day), or estrogen (n = 39): one capsule of 0.625 mg conjugated equine estrogens and other capsule with glucose 0.625 mg (placebo).Results: After treatment, there was a decrease in the symptomatology in both estrogen and isoflavone groups. There was a significant decrease in vaginal pH, an increase in superficial vaginal cells and endometrium proliferation after 3 and 6 months of treatment in the estrogen group, but no differences were observed in the isoflavone group for these variables.Conclusions: We concluded that the daily standardized soy extract with 120 mg isoflavones' effect on symptoms was similar to that from estrogen. Soy isoflavone has no effect on endometrium and vaginal mucosa during the treatment. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-01-10 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:40:54Z |
dc.date.available.fl_str_mv |
2016-01-24T12:40:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Maturitas. Clare: Elsevier B.V., v. 53, n. 1, p. 49-58, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/28690 http://dx.doi.org/10.1016/j.maturitas.2005.02.009 |
dc.identifier.issn.none.fl_str_mv |
0378-5122 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.maturitas.2005.02.009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000234640100007 |
identifier_str_mv |
Maturitas. Clare: Elsevier B.V., v. 53, n. 1, p. 49-58, 2006. 0378-5122 10.1016/j.maturitas.2005.02.009 WOS:000234640100007 |
url |
http://repositorio.unifesp.br/handle/11600/28690 http://dx.doi.org/10.1016/j.maturitas.2005.02.009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Maturitas |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
49-58 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460336151560192 |