Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/55012 http://dx.doi.org/10.1167/iovs.16-20977 |
Resumo: | PURPOSE. To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm. METHODS. Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 x 3-mm and 6 x 6-mm scans. The complex optical microangiography (OMAG(C)) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 mu m below Bruch's membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well. RESULTS. Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 x 3-mm (P = 0.61, paired t-test) and 6 x 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 x 3-mm (P = 0.41, paired t-test) and 6 x 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 3 3-mm scans (P = 0.011, paired sample t-test) and the 6 x 6-mm scans (P = 0.021, paired t-test). CONCLUSIONS. The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements. |
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Zhang, QinqinChen, Chieh-LiChu, ZhongdiZheng, FangMiller, AndrewRoisman, Luiz [UNIFESP]Dias, Joao Rafael de OliveiraYehoshua, ZoharSchaal, Karen B.Feuer, WilliamGregori, GiovanniKubach, SophieAn, LinStetson, Paul F.Durbin, Mary K.Rosenfeld, Philip J.Wang, Ruikang K.2020-07-17T14:02:47Z2020-07-17T14:02:47Z2017Investigative Ophthalmology & Visual Science. Rockville, v. 58, n. 3, p. 1506-1513, 2017.0146-0404https://repositorio.unifesp.br/handle/11600/55012http://dx.doi.org/10.1167/iovs.16-20977WOS000398089000019.pdf10.1167/iovs.16-20977WOS:000398089000019PURPOSE. To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm. METHODS. Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 x 3-mm and 6 x 6-mm scans. The complex optical microangiography (OMAG(C)) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 mu m below Bruch's membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well. RESULTS. Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 x 3-mm (P = 0.61, paired t-test) and 6 x 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 x 3-mm (P = 0.41, paired t-test) and 6 x 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 3 3-mm scans (P = 0.011, paired sample t-test) and the 6 x 6-mm scans (P = 0.021, paired t-test). CONCLUSIONS. The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements.Carl Zeiss Meditec, Inc. (Dublin, CA)National Eye InstituteResearch to Prevent Blindness, Inc., New York, New YorkNational Eye Institute Center Core GrantCAPES Foundation, Ministry of Education of Brazil, Brasilia-BrazilGerman Research Foundation (DFG)Research to Prevent BlindnessUniv Washington, Dept Bioengn, 3720 NE 15th Ave, Seattle, WA 98195 USAUniv Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USAUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, BrazilCarl Zeiss Meditec Inc, Adv Dev, Dublin, CA USAUniv Washington, Dept Ophthalmol, 3720 NE 15th Ave, Seattle, WA 98195 USAUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, BrazilNational Eye Institute: R01EY024158National Eye Institute Center Core Grant: P30EY014801German Research Foundation (DFG): SCHA 1869/1-1Web of Science1506-1513engAssoc Research Vision Ophthalmology IncInvestigative Ophthalmology & Visual Scienceoptical coherence tomographyswept-source OCTAspectral-domain OCTAneovascular AMDmacular neovascularizationpigment epithelium detachmentAutomated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiogramsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRockville583info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000398089000019.pdfapplication/pdf1075884${dspace.ui.url}/bitstream/11600/55012/1/WOS000398089000019.pdf6d6c30420d77a82ebc86cd5662af020eMD51open accessTEXTWOS000398089000019.pdf.txtWOS000398089000019.pdf.txtExtracted texttext/plain35572${dspace.ui.url}/bitstream/11600/55012/2/WOS000398089000019.pdf.txt5e971c02035ccec3addd2c439054cadfMD52open accessTHUMBNAILWOS000398089000019.pdf.jpgWOS000398089000019.pdf.jpgIM Thumbnailimage/jpeg7776${dspace.ui.url}/bitstream/11600/55012/4/WOS000398089000019.pdf.jpgc7137a75d23c0ffdee361bd10efa6dc1MD54open access11600/550122022-08-01 05:08:16.168open accessoai:repositorio.unifesp.br:11600/55012Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:51.398853Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
title |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
spellingShingle |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms Zhang, Qinqin optical coherence tomography swept-source OCTA spectral-domain OCTA neovascular AMD macular neovascularization pigment epithelium detachment |
title_short |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
title_full |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
title_fullStr |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
title_full_unstemmed |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
title_sort |
Automated Quantitation of Choroidal Neovascularization: A Comparison Study Between Spectral-Domain and Swept-Source OCT Angiograms |
author |
Zhang, Qinqin |
author_facet |
Zhang, Qinqin Chen, Chieh-Li Chu, Zhongdi Zheng, Fang Miller, Andrew Roisman, Luiz [UNIFESP] Dias, Joao Rafael de Oliveira Yehoshua, Zohar Schaal, Karen B. Feuer, William Gregori, Giovanni Kubach, Sophie An, Lin Stetson, Paul F. Durbin, Mary K. Rosenfeld, Philip J. Wang, Ruikang K. |
author_role |
author |
author2 |
Chen, Chieh-Li Chu, Zhongdi Zheng, Fang Miller, Andrew Roisman, Luiz [UNIFESP] Dias, Joao Rafael de Oliveira Yehoshua, Zohar Schaal, Karen B. Feuer, William Gregori, Giovanni Kubach, Sophie An, Lin Stetson, Paul F. Durbin, Mary K. Rosenfeld, Philip J. Wang, Ruikang K. |
author2_role |
author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zhang, Qinqin Chen, Chieh-Li Chu, Zhongdi Zheng, Fang Miller, Andrew Roisman, Luiz [UNIFESP] Dias, Joao Rafael de Oliveira Yehoshua, Zohar Schaal, Karen B. Feuer, William Gregori, Giovanni Kubach, Sophie An, Lin Stetson, Paul F. Durbin, Mary K. Rosenfeld, Philip J. Wang, Ruikang K. |
dc.subject.eng.fl_str_mv |
optical coherence tomography swept-source OCTA spectral-domain OCTA neovascular AMD macular neovascularization pigment epithelium detachment |
topic |
optical coherence tomography swept-source OCTA spectral-domain OCTA neovascular AMD macular neovascularization pigment epithelium detachment |
description |
PURPOSE. To compare the lesion sizes of choroidal neovascularization (CNV) imaged with spectral-domain (SD) and swept-source (SS) optical coherence tomography angiography (OCTA) and measured using an automated detection algorithm. METHODS. Patients diagnosed with CNV were imaged by SD-OCTA and SS-OCTA systems using 3 x 3-mm and 6 x 6-mm scans. The complex optical microangiography (OMAG(C)) algorithm was used to generate the OCTA images. Optical coherence tomography A datasets for imaging CNV were derived by segmenting from the outer retina to 8 mu m below Bruch's membrane. An artifact removal algorithm was used to generate angiograms free of retinal vessel projection artifacts. An automated detection algorithm was developed to quantify the size of the CNV. Automated measurements were compared with manual measurements. Measurements from SD-OCTA and SS-OCTA instruments were compared as well. RESULTS. Twenty-seven eyes from 23 subjects diagnosed with CNV were analyzed. No significant differences were detected between manual and automatic measurements: SD-OCTA 3 x 3-mm (P = 0.61, paired t-test) and 6 x 6-mm (P = 0.09, paired t-test) scans and the SS-OCTA 3 x 3-mm (P = 0.41, paired t-test) and 6 x 6-mm (P = 0.16, paired t-test) scans. Bland-Altman analyses were performed to confirm the agreement between automatic and manual measurements. Mean lesion sizes were significantly larger for the SS-OCTA images compared with the SD-OCTA images: 3 3 3-mm scans (P = 0.011, paired sample t-test) and the 6 x 6-mm scans (P = 0.021, paired t-test). CONCLUSIONS. The automated algorithm measurements of CNV were in agreement with the hand-drawn measurements. On average, automated SS-OCTA measurements were larger than SD-OCTA measurements and consistent with the results from using hand-drawn measurements. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-17T14:02:47Z |
dc.date.available.fl_str_mv |
2020-07-17T14:02:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Investigative Ophthalmology & Visual Science. Rockville, v. 58, n. 3, p. 1506-1513, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/55012 http://dx.doi.org/10.1167/iovs.16-20977 |
dc.identifier.issn.none.fl_str_mv |
0146-0404 |
dc.identifier.file.none.fl_str_mv |
WOS000398089000019.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1167/iovs.16-20977 |
dc.identifier.wos.none.fl_str_mv |
WOS:000398089000019 |
identifier_str_mv |
Investigative Ophthalmology & Visual Science. Rockville, v. 58, n. 3, p. 1506-1513, 2017. 0146-0404 WOS000398089000019.pdf 10.1167/iovs.16-20977 WOS:000398089000019 |
url |
https://repositorio.unifesp.br/handle/11600/55012 http://dx.doi.org/10.1167/iovs.16-20977 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Investigative Ophthalmology & Visual Science |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
1506-1513 |
dc.coverage.none.fl_str_mv |
Rockville |
dc.publisher.none.fl_str_mv |
Assoc Research Vision Ophthalmology Inc |
publisher.none.fl_str_mv |
Assoc Research Vision Ophthalmology Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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