Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma
Main Author: | |
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Publication Date: | 2007 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/3510 http://dx.doi.org/10.1590/S0100-879X2006005000067 |
Summary: | It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM. |
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Duch, Cibele Repele [UNIFESP]Figueiredo, Maria Stella [UNIFESP]Ribas, Christian [UNIFESP]Almeida, Manuella de Souza Sampaio [UNIFESP]Colleoni, Gisele Wally Braga [UNIFESP]Bordin, Jose Orlando [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:36:41Z2015-06-14T13:36:41Z2007-02-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 265-267, 2007.0100-879Xhttp://repositorio.unifesp.br/handle/11600/3510http://dx.doi.org/10.1590/S0100-879X2006005000067S0100-879X2007000200014.pdfS0100-879X200700020001410.1590/S0100-879X2006005000067WOS:000243977400014It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de MedicinaUNIFESP, EPMSciELO265-267engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchMultiple myelomaInterleukin-6PolymorphismsAnalysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myelomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2007000200014.pdfapplication/pdf464393${dspace.ui.url}/bitstream/11600/3510/1/S0100-879X2007000200014.pdf2bd048f1bf60bbd51cd58e74b0fcf405MD51open accessTEXTS0100-879X2007000200014.pdf.txtS0100-879X2007000200014.pdf.txtExtracted texttext/plain11337${dspace.ui.url}/bitstream/11600/3510/2/S0100-879X2007000200014.pdf.txt9c1f04ab9e6a7d8c1cca5f0791f41764MD52open access11600/35102023-02-15 11:04:59.702open accessoai:repositorio.unifesp.br:11600/3510Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:50.169454Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
title |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
spellingShingle |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma Duch, Cibele Repele [UNIFESP] Multiple myeloma Interleukin-6 Polymorphisms |
title_short |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
title_full |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
title_fullStr |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
title_full_unstemmed |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
title_sort |
Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma |
author |
Duch, Cibele Repele [UNIFESP] |
author_facet |
Duch, Cibele Repele [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Ribas, Christian [UNIFESP] Almeida, Manuella de Souza Sampaio [UNIFESP] Colleoni, Gisele Wally Braga [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
author_role |
author |
author2 |
Figueiredo, Maria Stella [UNIFESP] Ribas, Christian [UNIFESP] Almeida, Manuella de Souza Sampaio [UNIFESP] Colleoni, Gisele Wally Braga [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Duch, Cibele Repele [UNIFESP] Figueiredo, Maria Stella [UNIFESP] Ribas, Christian [UNIFESP] Almeida, Manuella de Souza Sampaio [UNIFESP] Colleoni, Gisele Wally Braga [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
dc.subject.eng.fl_str_mv |
Multiple myeloma Interleukin-6 Polymorphisms |
topic |
Multiple myeloma Interleukin-6 Polymorphisms |
description |
It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-02-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:36:41Z |
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2015-06-14T13:36:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 265-267, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3510 http://dx.doi.org/10.1590/S0100-879X2006005000067 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
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S0100-879X2007000200014.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2007000200014 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2006005000067 |
dc.identifier.wos.none.fl_str_mv |
WOS:000243977400014 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 265-267, 2007. 0100-879X S0100-879X2007000200014.pdf S0100-879X2007000200014 10.1590/S0100-879X2006005000067 WOS:000243977400014 |
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http://repositorio.unifesp.br/handle/11600/3510 http://dx.doi.org/10.1590/S0100-879X2006005000067 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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openAccess |
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265-267 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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