Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/39745 |
Resumo: | The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used. |
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Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms Potencial citotóxico e genotóxico de Ginkgo biloba L., nas formas industrializada e não aditivada GinkgoExcipientsCell divisionCellular changesMeristematic tissueBiological SciencesThe toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used.Avaliou-se, em células meristemáticas de raízes de Allium cepa, o potencial tóxico em nível celular de folhas de Ginkgo biloba L. industrializadas, nas concentrações 0,1; 0,2 e 0,4 mg/mL. Os produtos industrializados,oriundos de quatro laboratórios farmacêuticos, foram identificados como A, B, C e D. Também avaliou-se a toxicidade em nível celular de chás de folhas de ginkgo desidratadas, nas concentrações 0,15; 0,30 e 0,60 mg/mL. Os produtos desidratados foram adquiridos em ervanários certificados pela ANVISA. As raízes ficaram expostas aos chás e produtos industrializados por 24 e 48 horas. Os resultados obtidos foram submetidos ao teste Qui-quadrado, a 5%. No entanto, os produtos de ginkgo industrializados, em todas as concentrações, causaram efeito antiproliferativo. Ainda, os produtos adquiridos em farmácias não induziram alterações em número significativo aos meristemas de raízes. Portanto, os ginkgos industrializados promoveram citotoxicidade, porém, não foram genotóxicos frente ao bioensaio utilizado.EDUFU2018-08-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/3974510.14393/BJ-v34n1a2018-39745Bioscience Journal ; Vol. 34 No. 4 (2018): July/Aug.; 1017-1024Bioscience Journal ; v. 34 n. 4 (2018): July/Aug.; 1017-10241981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/39745/22661Brazil; ContemporaryCopyright (c) 2018 Clarice Moura Guedes, Fabelina Karollyne Silva dos Santos, Tamires Silva, Ana Paula Soares e Silva, Michele Vieira da Silva Lima, Valtânia Ana de Oliveira, Maria Eduarda Sousa Silva, Maria Carolina de Abreu, Ana Paula Paula Peronhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessGuedes, Clarice MouraSilva dos Santos, Fabelina KarollyneSilva, Tamirese Silva, Ana Paula SoaresLima, Michele Vieira da SilvaOliveira, Valtânia Ana deSilva, Maria Eduarda SousaAbreu, Maria Carolina dePeron, Ana Paula Paula2022-02-14T12:32:56Zoai:ojs.www.seer.ufu.br:article/39745Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-02-14T12:32:56Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms Potencial citotóxico e genotóxico de Ginkgo biloba L., nas formas industrializada e não aditivada |
title |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
spellingShingle |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms Guedes, Clarice Moura Ginkgo Excipients Cell division Cellular changes Meristematic tissue Biological Sciences |
title_short |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
title_full |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
title_fullStr |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
title_full_unstemmed |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
title_sort |
Cytotoxic and genotoxic potential of Ginkgo biloba L., in industrialized and without-additive forms |
author |
Guedes, Clarice Moura |
author_facet |
Guedes, Clarice Moura Silva dos Santos, Fabelina Karollyne Silva, Tamires e Silva, Ana Paula Soares Lima, Michele Vieira da Silva Oliveira, Valtânia Ana de Silva, Maria Eduarda Sousa Abreu, Maria Carolina de Peron, Ana Paula Paula |
author_role |
author |
author2 |
Silva dos Santos, Fabelina Karollyne Silva, Tamires e Silva, Ana Paula Soares Lima, Michele Vieira da Silva Oliveira, Valtânia Ana de Silva, Maria Eduarda Sousa Abreu, Maria Carolina de Peron, Ana Paula Paula |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guedes, Clarice Moura Silva dos Santos, Fabelina Karollyne Silva, Tamires e Silva, Ana Paula Soares Lima, Michele Vieira da Silva Oliveira, Valtânia Ana de Silva, Maria Eduarda Sousa Abreu, Maria Carolina de Peron, Ana Paula Paula |
dc.subject.por.fl_str_mv |
Ginkgo Excipients Cell division Cellular changes Meristematic tissue Biological Sciences |
topic |
Ginkgo Excipients Cell division Cellular changes Meristematic tissue Biological Sciences |
description |
The toxic potential at the cellular level of industrialized Ginkgo biloba L. leaves was evaluated in meristematic cells of Allium cepa at concentrations of 0.1; 0.2 and 0.4 mg/ml. The industrialized products, from four pharmaceutical laboratories, were identified as A, B, C and D. Cell-level toxicity of dehydrated ginkgo leaf tea was also evaluated at concentrations of 0.15; 0.30 and 0.60 mg/ml. Dehydrated products were purchased from herbalists certified by ANVISA. The roots were exposed to teas and processed products for 24 and 48 hours. The results were submitted to the Chi-square test at 5%. However, industrialized ginkgo products at all concentrations caused antiproliferative effect. Also, the products purchased in pharmacies did not induce significant changes to root meristems. Therefore, industrialized ginkgo promoted cytotoxicity, however, they were not genotoxic to the bioassay used. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-08-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/39745 10.14393/BJ-v34n1a2018-39745 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/39745 |
identifier_str_mv |
10.14393/BJ-v34n1a2018-39745 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/39745/22661 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
EDUFU |
publisher.none.fl_str_mv |
EDUFU |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 34 No. 4 (2018): July/Aug.; 1017-1024 Bioscience Journal ; v. 34 n. 4 (2018): July/Aug.; 1017-1024 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
_version_ |
1797069078969450496 |