Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro
Main Author: | |
---|---|
Publication Date: | 2007 |
Format: | Master thesis |
Language: | por |
Source: | Repositório Institucional da UFU |
Download full: | https://repositorio.ufu.br/handle/123456789/16740 |
Summary: | Nosocomial infections caused by antibiotic resistant bacteria represents a substantial problem due to increasing in mortality, morbidity and health-care costs, especially in intensive care units. This study evaluated the frequencies of epidemiologically important antibiotic resistance phenotypes, recovered from ventilator-associated pneumonia (VAP) in critically ill patients and urinary tract infection (UTI) and bloodstream infections (BSI) in critical and non-critical patients. An one year study was performed in the adult intensive care unit (AICU) of the Clinical Hospital (CH) of Federal University of Uberlândia, where clinical specimens were obtained for diagnosis of VAP and UTI; moreover, the laboratory of the CH provided data that was used to define all the cases of BSI and UTI in non-critical units; additionally, a monthly inquiry of the antimicrobials consumption was carried through in AICU at the period of the study. Coagulase-negative staphylococci predominated as etiological agent of BSI in critically ill (24.6%) and non-critical (30.6%) patients, with frequency of 60,0% of oxacilin-resistant coagulase-negative staphylococci; Klebsielleae (23.4%) and E. coli (29.6%) were the major cause of UTI in critical and non-critical patients, respectively, with resistance above 20.0% to third generation cephalosporins and P. aeruginosa (42.0%) was the main etiological agent of VAP, with rates of resistance to imipenem and fluoroquinolons above 70,0%. The prevalence study of antibiotic consumption in the AICU pointed to cephalosporins (49.6%), followed by vancomycin (37.4%) and carbapenems (26.6%) as the most prescribed antibiotics in the unit. The comparison of our findings with other national and international studies demonstrated a highest frequency of antibiotic resistant phenotype in our hospital, in critical and non-critical units, especially among the Gram-negative bacterias, however, it was not observed a significant variation between the frequency of resistance phenotypes recovered from critical and non-critical units, what strongly suggests that these phenotypes had already spread in the hospital, except P. aeruginosa whose resistance to antibiotic was more expressive when recovered from critical patients than non-critical ones. |
id |
UFU_872f52b8cc9617995315c1f28a6ddf57 |
---|---|
oai_identifier_str |
oai:repositorio.ufu.br:123456789/16740 |
network_acronym_str |
UFU |
network_name_str |
Repositório Institucional da UFU |
repository_id_str |
|
spelling |
2016-06-22T18:46:46Z2007-09-252016-06-22T18:46:46Z2007-07-27CARVALHO, Rodolfo Henriques de. Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro. 2007. 50 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Uberlândia, Uberlândia, 2007.https://repositorio.ufu.br/handle/123456789/16740Nosocomial infections caused by antibiotic resistant bacteria represents a substantial problem due to increasing in mortality, morbidity and health-care costs, especially in intensive care units. This study evaluated the frequencies of epidemiologically important antibiotic resistance phenotypes, recovered from ventilator-associated pneumonia (VAP) in critically ill patients and urinary tract infection (UTI) and bloodstream infections (BSI) in critical and non-critical patients. An one year study was performed in the adult intensive care unit (AICU) of the Clinical Hospital (CH) of Federal University of Uberlândia, where clinical specimens were obtained for diagnosis of VAP and UTI; moreover, the laboratory of the CH provided data that was used to define all the cases of BSI and UTI in non-critical units; additionally, a monthly inquiry of the antimicrobials consumption was carried through in AICU at the period of the study. Coagulase-negative staphylococci predominated as etiological agent of BSI in critically ill (24.6%) and non-critical (30.6%) patients, with frequency of 60,0% of oxacilin-resistant coagulase-negative staphylococci; Klebsielleae (23.4%) and E. coli (29.6%) were the major cause of UTI in critical and non-critical patients, respectively, with resistance above 20.0% to third generation cephalosporins and P. aeruginosa (42.0%) was the main etiological agent of VAP, with rates of resistance to imipenem and fluoroquinolons above 70,0%. The prevalence study of antibiotic consumption in the AICU pointed to cephalosporins (49.6%), followed by vancomycin (37.4%) and carbapenems (26.6%) as the most prescribed antibiotics in the unit. The comparison of our findings with other national and international studies demonstrated a highest frequency of antibiotic resistant phenotype in our hospital, in critical and non-critical units, especially among the Gram-negative bacterias, however, it was not observed a significant variation between the frequency of resistance phenotypes recovered from critical and non-critical units, what strongly suggests that these phenotypes had already spread in the hospital, except P. aeruginosa whose resistance to antibiotic was more expressive when recovered from critical patients than non-critical ones.Infecções hospitalares causadas por bactérias resistentes a antibióticos representam um problema expressivo quanto à morbidade, mortalidade e custos hospitalares, especialmente em unidades de terapia intensiva. Esse trabalho avaliou as freqüências de fenótipos de resistência a antimicrobianos dos patógenos epidemiologicamente importantes, isolados de pneumonia associada à ventilação mecânica (PAV) em pacientes críticos e de infecções de trato urinário (ITU) e de corrente sangüínea (ICS) em pacientes críticos e não críticos. Foi feita uma vigilância epidemiológica ativa na Unidade de Terapia Intensiva de adultos (UTIA) do Hospital de Clínicas da Universidade Federal de Uberlândia (HC-UFU), no período de um ano, coletando-se dados e espécimes clínicos para diagnóstico de PAV e ITU; além da coleta de dados no laboratório do HC para definir as ICS em pacientes críticos e não críticos e as ITU em unidades não críticas; adicionalmente, foram realizados no período do estudo, inquéritos mensais da prescrição de antimicrobianos na UTIA. Houve um predomínio do Staphylococcus spp coagulase negativo como agente etiológico das ICS em pacientes críticos (24,6%) e não críticos (30,6%) com 60,0% dos isolados resistentes a oxacilina; da tribo Klebsielleae (23,4%) e da E. coli (29,6%) como causa de ITU em pacientes críticos e não críticos, respectivamente, com resistência acima de 20,0% às cefalosporinas de terceira geração e da P. aeruginosa (42,0%) em isolados de PAV, com resistência acima de 70,0% para imipenem e fluoroquinolonas. A pesquisa do consumo de antibióticos na UTIA apontou as cefalosporinas (49,6%), seguidas por vancomicina (37,4%) e carbapenêmicos (26,6%) como os antimicrobianos mais prescritos na unidade. Comparando nossos achados com outros estudos epidemiológicos em unidades críticas e não críticas nacionais e internacionais, observou-se um elevado isolamento de fenótipos de resistência em nosso hospital, principalmente entre os Gramnegativos, entretanto, não foram observadas variações importantes entre o percentual de fenótipos de resistência aos antimicrobianos isolados nas unidades críticas e não críticas, o que sugere que estes fenótipos se encontram disseminados no hospital, exceto a P. aeruginosa cuja freqüência de resistência foi mais expressiva nos isolados obtidos de pacientes críticos do que aqueles de unidades não críticas.Mestre em Imunologia e Parasitologia Aplicadasapplication/pdfporUniversidade Federal de UberlândiaPrograma de Pós-graduação em Imunologia e Parasitologia AplicadasUFUBRCiências BiológicasInfecção hospitalarEpidemiologiaMicrorganismos multirresistentesNosocomial infectionEpidemiologyMultirresistant microorganismsCNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA::IMUNOLOGIA APLICADABactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiroinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisGontijo Filho, Paulo Pintohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787872T0Sadoyama, Geraldohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794560A3Fracalanzza, Sergio Eduardo Longohttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783965D6http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4227672H9Carvalho, Rodolfo Henriques deinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFUinstname:Universidade Federal de Uberlândia (UFU)instacron:UFUTHUMBNAILRHCarvalhoDISPRT.pdf.jpgRHCarvalhoDISPRT.pdf.jpgGenerated Thumbnailimage/jpeg1390https://repositorio.ufu.br/bitstream/123456789/16740/3/RHCarvalhoDISPRT.pdf.jpgd3137dcc9e119c390b8afbe147c53de6MD53ORIGINALRHCarvalhoDISPRT.pdfapplication/pdf1195943https://repositorio.ufu.br/bitstream/123456789/16740/1/RHCarvalhoDISPRT.pdf01f415f68b40fd4f601fc3c8816e5c3cMD51TEXTRHCarvalhoDISPRT.pdf.txtRHCarvalhoDISPRT.pdf.txtExtracted texttext/plain90407https://repositorio.ufu.br/bitstream/123456789/16740/2/RHCarvalhoDISPRT.pdf.txt367244c074d7189580e406f4a369f90eMD52123456789/167402016-06-23 04:42:56.916oai:repositorio.ufu.br:123456789/16740Repositório InstitucionalONGhttp://repositorio.ufu.br/oai/requestdiinf@dirbi.ufu.bropendoar:2024-04-26T14:51:46.719191Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU)false |
dc.title.por.fl_str_mv |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
title |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
spellingShingle |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro Carvalho, Rodolfo Henriques de Infecção hospitalar Epidemiologia Microrganismos multirresistentes Nosocomial infection Epidemiology Multirresistant microorganisms CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA::IMUNOLOGIA APLICADA |
title_short |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
title_full |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
title_fullStr |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
title_full_unstemmed |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
title_sort |
Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro |
author |
Carvalho, Rodolfo Henriques de |
author_facet |
Carvalho, Rodolfo Henriques de |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Gontijo Filho, Paulo Pinto |
dc.contributor.advisor1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787872T0 |
dc.contributor.referee1.fl_str_mv |
Sadoyama, Geraldo |
dc.contributor.referee1Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794560A3 |
dc.contributor.referee2.fl_str_mv |
Fracalanzza, Sergio Eduardo Longo |
dc.contributor.referee2Lattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783965D6 |
dc.contributor.authorLattes.fl_str_mv |
http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4227672H9 |
dc.contributor.author.fl_str_mv |
Carvalho, Rodolfo Henriques de |
contributor_str_mv |
Gontijo Filho, Paulo Pinto Sadoyama, Geraldo Fracalanzza, Sergio Eduardo Longo |
dc.subject.por.fl_str_mv |
Infecção hospitalar Epidemiologia Microrganismos multirresistentes |
topic |
Infecção hospitalar Epidemiologia Microrganismos multirresistentes Nosocomial infection Epidemiology Multirresistant microorganisms CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA::IMUNOLOGIA APLICADA |
dc.subject.eng.fl_str_mv |
Nosocomial infection Epidemiology Multirresistant microorganisms |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA::IMUNOLOGIA APLICADA |
description |
Nosocomial infections caused by antibiotic resistant bacteria represents a substantial problem due to increasing in mortality, morbidity and health-care costs, especially in intensive care units. This study evaluated the frequencies of epidemiologically important antibiotic resistance phenotypes, recovered from ventilator-associated pneumonia (VAP) in critically ill patients and urinary tract infection (UTI) and bloodstream infections (BSI) in critical and non-critical patients. An one year study was performed in the adult intensive care unit (AICU) of the Clinical Hospital (CH) of Federal University of Uberlândia, where clinical specimens were obtained for diagnosis of VAP and UTI; moreover, the laboratory of the CH provided data that was used to define all the cases of BSI and UTI in non-critical units; additionally, a monthly inquiry of the antimicrobials consumption was carried through in AICU at the period of the study. Coagulase-negative staphylococci predominated as etiological agent of BSI in critically ill (24.6%) and non-critical (30.6%) patients, with frequency of 60,0% of oxacilin-resistant coagulase-negative staphylococci; Klebsielleae (23.4%) and E. coli (29.6%) were the major cause of UTI in critical and non-critical patients, respectively, with resistance above 20.0% to third generation cephalosporins and P. aeruginosa (42.0%) was the main etiological agent of VAP, with rates of resistance to imipenem and fluoroquinolons above 70,0%. The prevalence study of antibiotic consumption in the AICU pointed to cephalosporins (49.6%), followed by vancomycin (37.4%) and carbapenems (26.6%) as the most prescribed antibiotics in the unit. The comparison of our findings with other national and international studies demonstrated a highest frequency of antibiotic resistant phenotype in our hospital, in critical and non-critical units, especially among the Gram-negative bacterias, however, it was not observed a significant variation between the frequency of resistance phenotypes recovered from critical and non-critical units, what strongly suggests that these phenotypes had already spread in the hospital, except P. aeruginosa whose resistance to antibiotic was more expressive when recovered from critical patients than non-critical ones. |
publishDate |
2007 |
dc.date.available.fl_str_mv |
2007-09-25 2016-06-22T18:46:46Z |
dc.date.issued.fl_str_mv |
2007-07-27 |
dc.date.accessioned.fl_str_mv |
2016-06-22T18:46:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CARVALHO, Rodolfo Henriques de. Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro. 2007. 50 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Uberlândia, Uberlândia, 2007. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufu.br/handle/123456789/16740 |
identifier_str_mv |
CARVALHO, Rodolfo Henriques de. Bactérias resistentes e multirresistentes a antibióticos nos pacientes internados em uma UTI de adultos de hospital universitário brasileiro. 2007. 50 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Uberlândia, Uberlândia, 2007. |
url |
https://repositorio.ufu.br/handle/123456789/16740 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Imunologia e Parasitologia Aplicadas |
dc.publisher.initials.fl_str_mv |
UFU |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Ciências Biológicas |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFU instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Repositório Institucional da UFU |
collection |
Repositório Institucional da UFU |
bitstream.url.fl_str_mv |
https://repositorio.ufu.br/bitstream/123456789/16740/3/RHCarvalhoDISPRT.pdf.jpg https://repositorio.ufu.br/bitstream/123456789/16740/1/RHCarvalhoDISPRT.pdf https://repositorio.ufu.br/bitstream/123456789/16740/2/RHCarvalhoDISPRT.pdf.txt |
bitstream.checksum.fl_str_mv |
d3137dcc9e119c390b8afbe147c53de6 01f415f68b40fd4f601fc3c8816e5c3c 367244c074d7189580e406f4a369f90e |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFU - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
diinf@dirbi.ufu.br |
_version_ |
1797425451243667456 |