Synbiotic meal decreases uremic toxins in hemodialysis individuals: A placebo-controlled trial

• Autor(a) principal: Lopes, Rita de Cássia Stampini Oliveira
• Data de Publicação: 2019
• Outros Autores: Theodoro, Jaqueline Maciel Vieira, Silva, Bárbara Pereira da, Queiroz, Valéria Aparecida Vieira, Moreira, Maria Eliza de Castro, Mantovani, Hilário Cuquetto, Hermsdorff, Helen Hermana, Martino, Hércia Stampini Duarte
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: https://doi.org/10.1016/j.foodres.2018.08.024; http://www.locus.ufv.br/handle/123456789/23905
• topic: Bifidobacterium longum; Chronic kidney disease; Indoxyl sulfate; p-Cresylsulfate; Sorghum bicolor L.; Urea

Generation of uremic toxins p-cresylsulfate (p-CS), indoxyl sulfate (IS) and indole 3-acetic acid (IAA) in hemodialysis (HD) individuals may be associated with the gut flora and recognized markers of disease progression. This study investigated the effect of synbiotic meal on uremic toxins in HD individuals. We conducted randomized singleblind and placebo-controlled intervention study with 58 HD subjects (20F/38M, 63.1 ± 10.9-old) who were randomly allocated in synbiotic group (SG, 40 g of extruded sorghum plus 100 mL of unfermented probiotic milk) or control group (CG, 40 g of extruded corn plus 100 mL of pasteurized milk), during 7-wk Metabolic markers and uremic toxins, fecal concentration of short chain fatty acid and pH value was determined. The SG group had decreased serum p-CS and IS, as well as decreased urea concentration (p < .05) compared to CG. SG showed higher fecal butyric acid and lower pH compared to baseline and SC (p < .05). In addition, serum p-CS and fecal pH were positively correlated to urea concentration in SG participants at the endpoint. The consumption of the synbiotic meal during 7-wk reduced colonic pH, and reduced serum uremic (p-CS and IS) toxins and urea in HD subjects.