Serum Klotho (but not haplotypes) associate with the post-myocardial infarction status of older adults

• Autor(a) principal: Paula, Roberta S.
• Data de Publicação: 2016
• Outros Autores: Souza, Vinícius C., Machado-Silva, Wilcelly, Almeida, Bruno Ratier S., Daros, Andersen C., Gomes, Lucy, Ferreira, Aparecido P., Brito, Ciro J., Córdova, Cláudio, Moraes, Clayton F., Nóbrega, Otávio T.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UnB
• Texto Completo: http://repositorio.unb.br/handle/10482/30394; http://dx.doi.org/10.6061/clinics/2016(12)09
• topic: Biomarcadores; Idosos; Infarto

The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p<0.001), and these associations were independent of the context. CONCLUSION: Our results suggest that serum Klotho is higher in individuals with a clinical history of myocardial infarction but not with a history of coronary artery disease or stroke. None of the Klotho haplotypes were associated with the variables investigated herein.