Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom

Detalhes bibliográficos
Autor(a) principal: Sangiorgio,F.
Data de Publicação: 2008
Outros Autores: Sakate,M., Nogueira,R. M. B., Tostes,R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100007
Resumo: The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
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spelling Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venomhistopathologyCrotalus durissus terrificusdogstreatmentintoxicationThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100007Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/S1678-91992008000100007info:eu-repo/semantics/openAccessSangiorgio,F.Sakate,M.Nogueira,R. M. B.Tostes,R. A.eng2009-09-11T00:00:00Zoai:scielo:S1678-91992008000100007Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2009-09-11T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
spellingShingle Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
Sangiorgio,F.
histopathology
Crotalus durissus terrificus
dogs
treatment
intoxication
title_short Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_full Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_fullStr Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_full_unstemmed Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_sort Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
author Sangiorgio,F.
author_facet Sangiorgio,F.
Sakate,M.
Nogueira,R. M. B.
Tostes,R. A.
author_role author
author2 Sakate,M.
Nogueira,R. M. B.
Tostes,R. A.
author2_role author
author
author
dc.contributor.author.fl_str_mv Sangiorgio,F.
Sakate,M.
Nogueira,R. M. B.
Tostes,R. A.
dc.subject.por.fl_str_mv histopathology
Crotalus durissus terrificus
dogs
treatment
intoxication
topic histopathology
Crotalus durissus terrificus
dogs
treatment
intoxication
description The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1678-91992008000100007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publisher.none.fl_str_mv Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
dc.source.none.fl_str_mv Journal of Venomous Animals and Toxins including Tropical Diseases v.14 n.1 2008
reponame:The Journal of venomous animals and toxins including tropical diseases (Online)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str The Journal of venomous animals and toxins including tropical diseases (Online)
collection The Journal of venomous animals and toxins including tropical diseases (Online)
repository.name.fl_str_mv The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv ||editorial@jvat.org.br
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