Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom

Detalhes bibliográficos
Autor(a) principal: Sangiorgio, Fabíola [UNESP]
Data de Publicação: 2008
Outros Autores: Sakate, M. [UNESP], Nogueira, R. M.B., Tostes, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1678-91992008000100007
http://hdl.handle.net/11449/225098
Resumo: The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
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spelling Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venomCrotalus durissus terrificusDogsHistopathologyIntoxicationTreatmentThe present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.Department of Small Animal Medical Clinic and Toxicology School of Veterinary Medicine and Animal Husbrandy São Paulo State University - UNESP, Botucatu, São Paulo StateDepartment of Small Animal Medical Clinic University of Western São Paulo UNOESTE, Presidente Prudente, São Paulo StateMaringá University Center CESUMAR, Maringá, Paraná StateDepartment of Small Animal Medical Clinic and Toxicology School of Veterinary Medicine and Animal Husbrandy São Paulo State University - UNESP, Botucatu, São Paulo StateUniversidade Estadual Paulista (UNESP)UNOESTECESUMARSangiorgio, Fabíola [UNESP]Sakate, M. [UNESP]Nogueira, R. M.B.Tostes, R. A.2022-04-28T20:39:26Z2022-04-28T20:39:26Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article82-99http://dx.doi.org/10.1590/S1678-91992008000100007Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 1, p. 82-99, 2008.1678-9199http://hdl.handle.net/11449/22509810.1590/S1678-919920080001000072-s2.0-41749118176Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxins Including Tropical Diseasesinfo:eu-repo/semantics/openAccess2022-04-28T20:39:26Zoai:repositorio.unesp.br:11449/225098Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T20:39:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
spellingShingle Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
Sangiorgio, Fabíola [UNESP]
Crotalus durissus terrificus
Dogs
Histopathology
Intoxication
Treatment
title_short Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_full Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_fullStr Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_full_unstemmed Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
title_sort Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
author Sangiorgio, Fabíola [UNESP]
author_facet Sangiorgio, Fabíola [UNESP]
Sakate, M. [UNESP]
Nogueira, R. M.B.
Tostes, R. A.
author_role author
author2 Sakate, M. [UNESP]
Nogueira, R. M.B.
Tostes, R. A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
UNOESTE
CESUMAR
dc.contributor.author.fl_str_mv Sangiorgio, Fabíola [UNESP]
Sakate, M. [UNESP]
Nogueira, R. M.B.
Tostes, R. A.
dc.subject.por.fl_str_mv Crotalus durissus terrificus
Dogs
Histopathology
Intoxication
Treatment
topic Crotalus durissus terrificus
Dogs
Histopathology
Intoxication
Treatment
description The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2022-04-28T20:39:26Z
2022-04-28T20:39:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1678-91992008000100007
Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 1, p. 82-99, 2008.
1678-9199
http://hdl.handle.net/11449/225098
10.1590/S1678-91992008000100007
2-s2.0-41749118176
url http://dx.doi.org/10.1590/S1678-91992008000100007
http://hdl.handle.net/11449/225098
identifier_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 1, p. 82-99, 2008.
1678-9199
10.1590/S1678-91992008000100007
2-s2.0-41749118176
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Venomous Animals and Toxins Including Tropical Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 82-99
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797789656569348096

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