Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Frezza, T. F.
Data de Publicação: 2007
Outros Autores: Madi, R. R., Banin, T. M., Pinto, Mara Cristina [UNESP], Souza, A. L. R. [UNESP], Gremião, Maria Palmira Daflon [UNESP], Allegretti, Silmara Marques
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332
http://hdl.handle.net/11449/70140
Resumo: Mansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue.
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spelling Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoniEffect of praziquantel in liposomes on Schistosoma mansoni eggs at different development stagesLiposomeOogramPraziquantelSchistosoma mansoniliposomepraziquantelanimal experimentanimal tissueantiprotozoal activityclinical researchcontrolled studydevelopmental stagedrug coatingegg layingexperimental infectionmousemouse strainnonhumanschistosomiasistherapy effecttreatment outcometreatment responseMansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue.A esquistossomose mansônica é causada pelo trematódeo digenético intravascular Schistosoma mansoni. Para o tratamento dessa enfermidade o praziquantel (PZQ) e a oxamniquina (OXA) são os fármacos escolhidos. No entanto, esses fármacos apresentam limitações quanto à ação e casos de resistência ou tolerância já foram relatados. Por esse motivo, são necessários os estudos de novas alternativas que visam melhorar os fármacos já existentes, como a incorporação desses em lipossomas. Este estudo verificou a ação do praziquantel incorporado a lipossomas (lip.PZQ) sobre os ovos de S. mansoni, linhagem BH em camundongos Mus musculus (Swiss- SPF). Para tanto, foram testadas quatro doses de PZQ e lip.PZQ (47; 60; 250 e 300mg/kg) sendo que parte dos camundongos foi tratada após 30 dias de infecção e outra após 45 dias. A análise do oograma mostrou que a dose lip.PZQ 300mg/kg administrada no 45º dia de infecção foi mais eficaz, pois reduziu a oviposição pelas fêmeas de S. mansoni.Departamento de Parasitologia Instituto de Biologie Universidade de Campinas, UNICAMP, Campinas, SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Parasitologia Instituto de Biologia Cidade Universitária Zeferino Vaz, s/n, Caixa Postal 6109, CEP: 13083-970 - Campinas - SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Frezza, T. F.Madi, R. R.Banin, T. M.Pinto, Mara Cristina [UNESP]Souza, A. L. R. [UNESP]Gremião, Maria Palmira Daflon [UNESP]Allegretti, Silmara Marques2014-05-27T11:22:43Z2014-05-27T11:22:43Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article209-214application/pdfhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007.1808-4532http://hdl.handle.net/11449/701402-s2.0-413491057462-s2.0-41349105746.pdf82217374915984159129780536724256Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista de Ciências Farmacêuticas Básica e Aplicada0,131info:eu-repo/semantics/openAccess2023-12-13T06:22:34Zoai:repositorio.unesp.br:11449/70140Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-13T06:22:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
Effect of praziquantel in liposomes on Schistosoma mansoni eggs at different development stages
title Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
spellingShingle Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
Frezza, T. F.
Liposome
Oogram
Praziquantel
Schistosoma mansoni
liposome
praziquantel
animal experiment
animal tissue
antiprotozoal activity
clinical research
controlled study
developmental stage
drug coating
egg laying
experimental infection
mouse
mouse strain
nonhuman
schistosomiasis
therapy effect
treatment outcome
treatment response
title_short Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
title_full Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
title_fullStr Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
title_full_unstemmed Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
title_sort Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
author Frezza, T. F.
author_facet Frezza, T. F.
Madi, R. R.
Banin, T. M.
Pinto, Mara Cristina [UNESP]
Souza, A. L. R. [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
Allegretti, Silmara Marques
author_role author
author2 Madi, R. R.
Banin, T. M.
Pinto, Mara Cristina [UNESP]
Souza, A. L. R. [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
Allegretti, Silmara Marques
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Frezza, T. F.
Madi, R. R.
Banin, T. M.
Pinto, Mara Cristina [UNESP]
Souza, A. L. R. [UNESP]
Gremião, Maria Palmira Daflon [UNESP]
Allegretti, Silmara Marques
dc.subject.por.fl_str_mv Liposome
Oogram
Praziquantel
Schistosoma mansoni
liposome
praziquantel
animal experiment
animal tissue
antiprotozoal activity
clinical research
controlled study
developmental stage
drug coating
egg laying
experimental infection
mouse
mouse strain
nonhuman
schistosomiasis
therapy effect
treatment outcome
treatment response
topic Liposome
Oogram
Praziquantel
Schistosoma mansoni
liposome
praziquantel
animal experiment
animal tissue
antiprotozoal activity
clinical research
controlled study
developmental stage
drug coating
egg laying
experimental infection
mouse
mouse strain
nonhuman
schistosomiasis
therapy effect
treatment outcome
treatment response
description Mansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue.
publishDate 2007
dc.date.none.fl_str_mv 2007-12-01
2014-05-27T11:22:43Z
2014-05-27T11:22:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007.
1808-4532
http://hdl.handle.net/11449/70140
2-s2.0-41349105746
2-s2.0-41349105746.pdf
8221737491598415
9129780536724256
url http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332
http://hdl.handle.net/11449/70140
identifier_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007.
1808-4532
2-s2.0-41349105746
2-s2.0-41349105746.pdf
8221737491598415
9129780536724256
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista de Ciências Farmacêuticas Básica e Aplicada
0,131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 209-214
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1792962071953932288

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