Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.medicinaoral.com/pubmed/medoralv11_i3_p247.pdf http://hdl.handle.net/11449/68877 |
Resumo: | OBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. Beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions. STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands). RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining. Nuclear beta-catenin immunostaining was not observed. The antibody presented a fine granular arrangement in the cytoplasm and cellular membrane of duct and acinic cells. Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas. There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas. CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma. |
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Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical studybeta cateninadultagedbiosynthesiscarcinomachildfemalehumanimmunohistochemistrymalemetabolismmiddle agedmultiple cancerpleomorphic adenomasalivary glandsalivary gland tumorAdenoma, PleomorphicAdultAgedbeta CateninCarcinomaChildFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasms, Multiple PrimarySalivary Gland NeoplasmsSalivary GlandsOBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. Beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions. STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands). RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining. Nuclear beta-catenin immunostaining was not observed. The antibody presented a fine granular arrangement in the cytoplasm and cellular membrane of duct and acinic cells. Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas. There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas. CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma.Universidade Estadual Paulista (Unesp)do Prado, Renata FalcheteConsolaro, AlbertoTaveira, Luís Antônio de Assis2014-05-27T11:21:52Z2014-05-27T11:21:52Z2006-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://www.medicinaoral.com/pubmed/medoralv11_i3_p247.pdfMedicina oral, patología oral y cirugía bucal., v. 11, n. 3, 2006.1698-6946http://hdl.handle.net/11449/688772-s2.0-337459255822-s2.0-33745925582.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedicina Oral Patologia Oral y Cirugia Bucal1.6710,841info:eu-repo/semantics/openAccess2023-11-22T06:16:16Zoai:repositorio.unesp.br:11449/68877Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-22T06:16:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
title |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
spellingShingle |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study do Prado, Renata Falchete beta catenin adult aged biosynthesis carcinoma child female human immunohistochemistry male metabolism middle aged multiple cancer pleomorphic adenoma salivary gland salivary gland tumor Adenoma, Pleomorphic Adult Aged beta Catenin Carcinoma Child Female Humans Immunohistochemistry Male Middle Aged Neoplasms, Multiple Primary Salivary Gland Neoplasms Salivary Glands |
title_short |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
title_full |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
title_fullStr |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
title_full_unstemmed |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
title_sort |
Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study |
author |
do Prado, Renata Falchete |
author_facet |
do Prado, Renata Falchete Consolaro, Alberto Taveira, Luís Antônio de Assis |
author_role |
author |
author2 |
Consolaro, Alberto Taveira, Luís Antônio de Assis |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
do Prado, Renata Falchete Consolaro, Alberto Taveira, Luís Antônio de Assis |
dc.subject.por.fl_str_mv |
beta catenin adult aged biosynthesis carcinoma child female human immunohistochemistry male metabolism middle aged multiple cancer pleomorphic adenoma salivary gland salivary gland tumor Adenoma, Pleomorphic Adult Aged beta Catenin Carcinoma Child Female Humans Immunohistochemistry Male Middle Aged Neoplasms, Multiple Primary Salivary Gland Neoplasms Salivary Glands |
topic |
beta catenin adult aged biosynthesis carcinoma child female human immunohistochemistry male metabolism middle aged multiple cancer pleomorphic adenoma salivary gland salivary gland tumor Adenoma, Pleomorphic Adult Aged beta Catenin Carcinoma Child Female Humans Immunohistochemistry Male Middle Aged Neoplasms, Multiple Primary Salivary Gland Neoplasms Salivary Glands |
description |
OBJECTIVES: Pleomorphic adenomas are the most frequent type of epithelial salivary gland neoplasms, and their malignant counterpart, the carcinoma in pleomorphic adenomas, is much less common. Beta-catenin is a cell adhesion molecule associated with the invasion and metastasis of carcinomas of the head and neck, esophagus. The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions. STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands). RESULTS: All cases of glands, adenomas and carcinomas in pleomorphic adenomas have membranous and cytoplasmic immunostaining. Nuclear beta-catenin immunostaining was not observed. The antibody presented a fine granular arrangement in the cytoplasm and cellular membrane of duct and acinic cells. Higher beta-catenin index rates were seen mainly in salivary gland ducts and in ductal structures in the adenomas and carcinomas in pleomorphic adenomas. There was protein loss in pleomorphic adenomas and cytoplasmic accumulation in carcinoma in pleomorphic adenomas. CONCLUSIONS: The present study showed participation of the loss of beta-catenin adhesion molecule in the development of pleomorphic adenoma, and that the cytoplasmic accumulation of the molecule takes part in the malignant transformation of the pleomorphic adenoma into carcinoma in pleomorphic adenoma. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-05-01 2014-05-27T11:21:52Z 2014-05-27T11:21:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.medicinaoral.com/pubmed/medoralv11_i3_p247.pdf Medicina oral, patología oral y cirugía bucal., v. 11, n. 3, 2006. 1698-6946 http://hdl.handle.net/11449/68877 2-s2.0-33745925582 2-s2.0-33745925582.pdf |
url |
http://www.medicinaoral.com/pubmed/medoralv11_i3_p247.pdf http://hdl.handle.net/11449/68877 |
identifier_str_mv |
Medicina oral, patología oral y cirugía bucal., v. 11, n. 3, 2006. 1698-6946 2-s2.0-33745925582 2-s2.0-33745925582.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medicina Oral Patologia Oral y Cirugia Bucal 1.671 0,841 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965031728676864 |