Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.11606/issn.1678-4456.v53i1p39-47 http://hdl.handle.net/11449/234391 |
Resumo: | The aim of this prospective study was to evaluate the clinical response of dogs with cutaneous lymphoma treated with lomustine (CCNU) and to identify possible adverse effects and toxicity during treatment. Fifteen dogs, seven females and eight males aged between five and 17 years old, diagnosed with cutaneous lymphoma by histopathological analysis were selected and treated with lomustine at 90 mg/m2 every three weeks. Monitoring was carried out and consisted of the assessment of laboratory hematology and serum chemistry before and during treatment. Partial response was observed in 53.3% of the animals. None of the animals achieved a complete response and seven dogs (46.6%) had progressive disease. The median survival time was 22 days. The major hematological and biochemical changes found after therapy were leukopenia (73.3%), thrombocytopenia (60%) and anemia (46.1%). Renal and liver toxicity was observed in 40% and 73.3% of dogs, respectively. Hematocrit, total protein, leukocyte count, neutrophil count, serum creatinine, ALT, GGT, alkaline phosphatase and urine specific gravity were affected during therapy. The use of lomustine as a monotherapy in the treatment of canine cutaneous lymphoma was effective; however, adverse effects occurred and compromised the quality of life of the majority of dogs in this study. Therefore, lower doses of lomustine should be considered in future studies. |
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Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustinaClinical and laboratorial evaluation of dogs with cutaneous lymphoma treated with lomustineAdverse effectsCCNUCutaneous lymphomaDogsOncologyThe aim of this prospective study was to evaluate the clinical response of dogs with cutaneous lymphoma treated with lomustine (CCNU) and to identify possible adverse effects and toxicity during treatment. Fifteen dogs, seven females and eight males aged between five and 17 years old, diagnosed with cutaneous lymphoma by histopathological analysis were selected and treated with lomustine at 90 mg/m2 every three weeks. Monitoring was carried out and consisted of the assessment of laboratory hematology and serum chemistry before and during treatment. Partial response was observed in 53.3% of the animals. None of the animals achieved a complete response and seven dogs (46.6%) had progressive disease. The median survival time was 22 days. The major hematological and biochemical changes found after therapy were leukopenia (73.3%), thrombocytopenia (60%) and anemia (46.1%). Renal and liver toxicity was observed in 40% and 73.3% of dogs, respectively. Hematocrit, total protein, leukocyte count, neutrophil count, serum creatinine, ALT, GGT, alkaline phosphatase and urine specific gravity were affected during therapy. The use of lomustine as a monotherapy in the treatment of canine cutaneous lymphoma was effective; however, adverse effects occurred and compromised the quality of life of the majority of dogs in this study. Therefore, lower doses of lomustine should be considered in future studies.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina Veterinária e ZootecniaUniversidade Estadual Paulista “Júlio de Mesquita Filho” Faculdade de Medicina Veterinária e ZootecniaFAPESP: 2010/15928-0Universidade Estadual Paulista (UNESP)Duarte, Amanda Resende [UNESP]Marques, Jéssica de Assis [UNESP]Zahn, Fabíola Soares [UNESP]Machado, Luiz Henrique de Araújo [UNESP]2022-05-02T13:44:46Z2022-05-02T13:44:46Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article39-47http://dx.doi.org/10.11606/issn.1678-4456.v53i1p39-47Brazilian Journal of Veterinary Research and Animal Science, v. 53, n. 1, p. 39-47, 2016.1678-44561413-9596http://hdl.handle.net/11449/23439110.11606/issn.1678-4456.v53i1p39-472-s2.0-84963591523Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Veterinary Research and Animal Scienceinfo:eu-repo/semantics/openAccess2022-05-02T13:44:46Zoai:repositorio.unesp.br:11449/234391Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-02T13:44:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina Clinical and laboratorial evaluation of dogs with cutaneous lymphoma treated with lomustine |
title |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
spellingShingle |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina Duarte, Amanda Resende [UNESP] Adverse effects CCNU Cutaneous lymphoma Dogs Oncology |
title_short |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
title_full |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
title_fullStr |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
title_full_unstemmed |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
title_sort |
Avaliação clínica e laboratorial de cães com linfoma cutâneo tratados com lomustina |
author |
Duarte, Amanda Resende [UNESP] |
author_facet |
Duarte, Amanda Resende [UNESP] Marques, Jéssica de Assis [UNESP] Zahn, Fabíola Soares [UNESP] Machado, Luiz Henrique de Araújo [UNESP] |
author_role |
author |
author2 |
Marques, Jéssica de Assis [UNESP] Zahn, Fabíola Soares [UNESP] Machado, Luiz Henrique de Araújo [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Duarte, Amanda Resende [UNESP] Marques, Jéssica de Assis [UNESP] Zahn, Fabíola Soares [UNESP] Machado, Luiz Henrique de Araújo [UNESP] |
dc.subject.por.fl_str_mv |
Adverse effects CCNU Cutaneous lymphoma Dogs Oncology |
topic |
Adverse effects CCNU Cutaneous lymphoma Dogs Oncology |
description |
The aim of this prospective study was to evaluate the clinical response of dogs with cutaneous lymphoma treated with lomustine (CCNU) and to identify possible adverse effects and toxicity during treatment. Fifteen dogs, seven females and eight males aged between five and 17 years old, diagnosed with cutaneous lymphoma by histopathological analysis were selected and treated with lomustine at 90 mg/m2 every three weeks. Monitoring was carried out and consisted of the assessment of laboratory hematology and serum chemistry before and during treatment. Partial response was observed in 53.3% of the animals. None of the animals achieved a complete response and seven dogs (46.6%) had progressive disease. The median survival time was 22 days. The major hematological and biochemical changes found after therapy were leukopenia (73.3%), thrombocytopenia (60%) and anemia (46.1%). Renal and liver toxicity was observed in 40% and 73.3% of dogs, respectively. Hematocrit, total protein, leukocyte count, neutrophil count, serum creatinine, ALT, GGT, alkaline phosphatase and urine specific gravity were affected during therapy. The use of lomustine as a monotherapy in the treatment of canine cutaneous lymphoma was effective; however, adverse effects occurred and compromised the quality of life of the majority of dogs in this study. Therefore, lower doses of lomustine should be considered in future studies. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2022-05-02T13:44:46Z 2022-05-02T13:44:46Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.11606/issn.1678-4456.v53i1p39-47 Brazilian Journal of Veterinary Research and Animal Science, v. 53, n. 1, p. 39-47, 2016. 1678-4456 1413-9596 http://hdl.handle.net/11449/234391 10.11606/issn.1678-4456.v53i1p39-47 2-s2.0-84963591523 |
url |
http://dx.doi.org/10.11606/issn.1678-4456.v53i1p39-47 http://hdl.handle.net/11449/234391 |
identifier_str_mv |
Brazilian Journal of Veterinary Research and Animal Science, v. 53, n. 1, p. 39-47, 2016. 1678-4456 1413-9596 10.11606/issn.1678-4456.v53i1p39-47 2-s2.0-84963591523 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
39-47 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964988220112896 |