The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology

Detalhes bibliográficos
Autor(a) principal: Sasahara, Tais H.C.
Data de Publicação: 2019
Outros Autores: Machado, Marcia R.F. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/1678-5150-PVB-5808
http://hdl.handle.net/11449/187873
Resumo: Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.
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spelling The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphologyO efeito do 1-metil-4-fenil-1,2,3,6 tetrahidropiridina (MPTP) na morfologia do miocárdio de camundongoStudies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Cirurgia Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade de São Paulo (USP) Cidade Universitária, Avenida Prof. Orlando Marques de Paiva 87Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/nFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/nFAPESP: 2007/50524-5Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Sasahara, Tais H.C.Machado, Marcia R.F. [UNESP]2019-10-06T15:49:51Z2019-10-06T15:49:51Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article364-370application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5808Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019.1678-51500100-736Xhttp://hdl.handle.net/11449/18787310.1590/1678-5150-PVB-5808S0100-736X20190005003642-s2.0-85069048359S0100-736X2019000500364.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-12-30T06:16:46Zoai:repositorio.unesp.br:11449/187873Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-30T06:16:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
O efeito do 1-metil-4-fenil-1,2,3,6 tetrahidropiridina (MPTP) na morfologia do miocárdio de camundongo
title The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
spellingShingle The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
Sasahara, Tais H.C.
title_short The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_full The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_fullStr The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_full_unstemmed The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
title_sort The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
author Sasahara, Tais H.C.
author_facet Sasahara, Tais H.C.
Machado, Marcia R.F. [UNESP]
author_role author
author2 Machado, Marcia R.F. [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Sasahara, Tais H.C.
Machado, Marcia R.F. [UNESP]
description Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.
publishDate 2019
dc.date.none.fl_str_mv 2019-10-06T15:49:51Z
2019-10-06T15:49:51Z
2019-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1678-5150-PVB-5808
Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019.
1678-5150
0100-736X
http://hdl.handle.net/11449/187873
10.1590/1678-5150-PVB-5808
S0100-736X2019000500364
2-s2.0-85069048359
S0100-736X2019000500364.pdf
url http://dx.doi.org/10.1590/1678-5150-PVB-5808
http://hdl.handle.net/11449/187873
identifier_str_mv Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019.
1678-5150
0100-736X
10.1590/1678-5150-PVB-5808
S0100-736X2019000500364
2-s2.0-85069048359
S0100-736X2019000500364.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pesquisa Veterinaria Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 364-370
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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