The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-5150-PVB-5808 http://hdl.handle.net/11449/187873 |
Resumo: | Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle. |
id |
UNSP_3ac568b759eaa0dd4434f03bd88733eb |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/187873 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphologyO efeito do 1-metil-4-fenil-1,2,3,6 tetrahidropiridina (MPTP) na morfologia do miocárdio de camundongoStudies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Departamento de Cirurgia Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade de São Paulo (USP) Cidade Universitária, Avenida Prof. Orlando Marques de Paiva 87Faculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/nFaculdade de Ciências Agrárias e Veterinárias (FCAV) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp) Campus de Jaboticabal, Via de Acesso Prof. Paulo Donato Castellane s/nFAPESP: 2007/50524-5Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Sasahara, Tais H.C.Machado, Marcia R.F. [UNESP]2019-10-06T15:49:51Z2019-10-06T15:49:51Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article364-370application/pdfhttp://dx.doi.org/10.1590/1678-5150-PVB-5808Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019.1678-51500100-736Xhttp://hdl.handle.net/11449/18787310.1590/1678-5150-PVB-5808S0100-736X20190005003642-s2.0-85069048359S0100-736X2019000500364.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2023-12-30T06:16:46Zoai:repositorio.unesp.br:11449/187873Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-30T06:16:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology O efeito do 1-metil-4-fenil-1,2,3,6 tetrahidropiridina (MPTP) na morfologia do miocárdio de camundongo |
title |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
spellingShingle |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology Sasahara, Tais H.C. |
title_short |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
title_full |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
title_fullStr |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
title_full_unstemmed |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
title_sort |
The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mice myocardial morphology |
author |
Sasahara, Tais H.C. |
author_facet |
Sasahara, Tais H.C. Machado, Marcia R.F. [UNESP] |
author_role |
author |
author2 |
Machado, Marcia R.F. [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Sasahara, Tais H.C. Machado, Marcia R.F. [UNESP] |
description |
Studies have demonstrated sympathetic cardiac denervation in the MPTP mouse model. MPTP toxicity causes sympathetic nerve damage and depletion of heart norepinephrine. Previous evaluations of impairments in heart innervation have been based on imaging, electrophysiological and biochemical methods. However, these studies lacked information that can be obtained from morphoquantitative analyses. Thus, this study aimed to apply a design-based stereological method for evaluating the morphoquantitative alterations of myocardium following treatment with the neurotoxin MPTP in the C57/BL mouse. Our results showed that MPTP reduced the number of cardiomyocytes in the left ventricle. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:49:51Z 2019-10-06T15:49:51Z 2019-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-5150-PVB-5808 Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019. 1678-5150 0100-736X http://hdl.handle.net/11449/187873 10.1590/1678-5150-PVB-5808 S0100-736X2019000500364 2-s2.0-85069048359 S0100-736X2019000500364.pdf |
url |
http://dx.doi.org/10.1590/1678-5150-PVB-5808 http://hdl.handle.net/11449/187873 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 39, n. 5, p. 364-370, 2019. 1678-5150 0100-736X 10.1590/1678-5150-PVB-5808 S0100-736X2019000500364 2-s2.0-85069048359 S0100-736X2019000500364.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
364-370 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965453824557056 |