An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0104-79302000000200004 http://hdl.handle.net/11449/212341 |
Resumo: | The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 – preoperative, T1 – 7th day postoperative, T2 – 14th day postoperative, and T3 – 21 st day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength values between the 2 groups. There was a decrease in the bursting strength values up until the 7 th day postoperative in both groups with its progressive increase at the other times. Although important experimental studies using large animals are needed for a better evaluation of tissue repair processes, this adhesive may become a valuable tool for use in anastomosis. |
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Repositório Institucional da UNESP |
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An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venomFibrin glueexperimental healingbursting strengthexperimental anastomosissnake venomcolon anastomosisThe objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 – preoperative, T1 – 7th day postoperative, T2 – 14th day postoperative, and T3 – 21 st day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength values between the 2 groups. There was a decrease in the bursting strength values up until the 7 th day postoperative in both groups with its progressive increase at the other times. Although important experimental studies using large animals are needed for a better evaluation of tissue repair processes, this adhesive may become a valuable tool for use in anastomosis.Universidade Estadual Paulista, Botucatu School of Medicine (FMB)Universidade Estadual Paulista, Center for the Study of Venoms and Venomous Animals - CEVAPUniversidade Estadual Paulista, School of Pharmaceutical Sciences of AraraquaraUniversidade Estadual Paulista, Botucatu School of Medicine (FMB)Universidade Estadual Paulista, Center for the Study of Venoms and Venomous Animals - CEVAPUniversidade Estadual Paulista, School of Pharmaceutical Sciences of AraraquaraCentro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESPUniversidade Estadual Paulista (Unesp)Leite, C.v.s. [UNESP]Naresse, L.e. [UNESP]Arantes, H.l.Lopes, A.f.Thomazini-santos, I.a. [UNESP]Giannini, M.j.s [UNESP]Mercadante, M.c. [UNESP]Barraviera, B. [UNESP]Kobayasi, S. [UNESP]2021-07-14T10:38:24Z2021-07-14T10:38:24Z2000info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article180-193http://dx.doi.org/10.1590/S0104-79302000000200004Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 6, n. 2, p. 180-193, 2000.0104-79301678-4936http://hdl.handle.net/11449/21234110.1590/S0104-79302000000200004S0104-79302000000200004S0104-79302000000200004.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Venomous Animals and Toxinsinfo:eu-repo/semantics/openAccess2024-04-11T15:28:26Zoai:repositorio.unesp.br:11449/212341Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T15:28:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
title |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
spellingShingle |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom Leite, C.v.s. [UNESP] Fibrin glue experimental healing bursting strength experimental anastomosis snake venom colon anastomosis |
title_short |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
title_full |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
title_fullStr |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
title_full_unstemmed |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
title_sort |
An evaluation by rat colon anastomosis of the efficacy of fibrin glue derived from snake venom |
author |
Leite, C.v.s. [UNESP] |
author_facet |
Leite, C.v.s. [UNESP] Naresse, L.e. [UNESP] Arantes, H.l. Lopes, A.f. Thomazini-santos, I.a. [UNESP] Giannini, M.j.s [UNESP] Mercadante, M.c. [UNESP] Barraviera, B. [UNESP] Kobayasi, S. [UNESP] |
author_role |
author |
author2 |
Naresse, L.e. [UNESP] Arantes, H.l. Lopes, A.f. Thomazini-santos, I.a. [UNESP] Giannini, M.j.s [UNESP] Mercadante, M.c. [UNESP] Barraviera, B. [UNESP] Kobayasi, S. [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Leite, C.v.s. [UNESP] Naresse, L.e. [UNESP] Arantes, H.l. Lopes, A.f. Thomazini-santos, I.a. [UNESP] Giannini, M.j.s [UNESP] Mercadante, M.c. [UNESP] Barraviera, B. [UNESP] Kobayasi, S. [UNESP] |
dc.subject.por.fl_str_mv |
Fibrin glue experimental healing bursting strength experimental anastomosis snake venom colon anastomosis |
topic |
Fibrin glue experimental healing bursting strength experimental anastomosis snake venom colon anastomosis |
description |
The objective of this study was to evaluate the efficacy of fibrin adhesive made up of snake venom and bubaline fibrinogen by rat colon anastomosis. Eighty rats were randomly assigned into 2 experimental groups: GI control (anastomosis with extramucous interrupted suture) and GII (repair suture + fibrin glue). The animals were studied at the following 4 times: T0 – preoperative, T1 – 7th day postoperative, T2 – 14th day postoperative, and T3 – 21 st day postoperative. The macroscopic characteristics of the intestinal segment open and closed anastomosis and the bursting strength of the anastomosed segments were observed at each of the above times. The results showed that the anastomosed segments coapted and there was no difference in the bursting strength values between the 2 groups. There was a decrease in the bursting strength values up until the 7 th day postoperative in both groups with its progressive increase at the other times. Although important experimental studies using large animals are needed for a better evaluation of tissue repair processes, this adhesive may become a valuable tool for use in anastomosis. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000 2021-07-14T10:38:24Z 2021-07-14T10:38:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0104-79302000000200004 Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 6, n. 2, p. 180-193, 2000. 0104-7930 1678-4936 http://hdl.handle.net/11449/212341 10.1590/S0104-79302000000200004 S0104-79302000000200004 S0104-79302000000200004.pdf |
url |
http://dx.doi.org/10.1590/S0104-79302000000200004 http://hdl.handle.net/11449/212341 |
identifier_str_mv |
Journal of Venomous Animals and Toxins. Botucatu, SP, Brazil: Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 6, n. 2, p. 180-193, 2000. 0104-7930 1678-4936 10.1590/S0104-79302000000200004 S0104-79302000000200004 S0104-79302000000200004.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Venomous Animals and Toxins |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
180-193 |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965631337988096 |