Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3389/fvets.2021.611729 http://hdl.handle.net/11449/207389 |
Resumo: | The lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine in low/high doses alone (DL 2.5 μg/kg + 6.25 μg/kg/h; DH 5 μg/kg +12.5 μg/kg/h) or associated with methadone (DLM and DHM, 0.2 mg/kg + 0.05 mg/kg/h) and with low (ACPL 0.02 mg/kg) or high (ACPH 0.09 mg/kg) doses of acepromazine alone. Horses were filmed at (i) baseline (ii) peak, (iii) intermediate, and (iv) end of sedation immediately before auditory, visual and pressure stimuli were applied and postural instability evaluated for another study. Videos were randomized and blindly evaluated by four evaluators in two phases with 1-month interval. Intra- and interobserver reliability of the sum of EquiSed (Intraclass correlation coefficient) ranged between 0.84–0.94 and 0.45–0.88, respectively. The criterion validity was endorsed by the high Spearman correlation between the EquiSed and visual analog (0.77), numerical rating (0.76), and simple descriptive scales (0.70), and average correlation with head height above the ground (HHAG) (−0.52). The Friedman test confirmed the EquiSed responsiveness over time. The principal component analysis showed that all items of the scale had a load factor ≥ 0.50. The item-total Spearman correlation for all items ranged from 0.3 to 0.5, and the internal consistency was good (Cronbach's α = 0.73). The area under the curve of EquiSed HHAG as a predictive diagnostic measure was 0.88. The sensitivity of the EquiSed calculated according to the cut-off point (score 7 of the sum of the EquiSed) determined by the receiver operating characteristic curve, was 96% and specificity was 83%. EquiSed has good intra- and interobserver reliabilities and is valid to evaluate tranquilization and sedation in horses. |
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Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed)acepromazine maleatedetomidinehorsesmethadonescalesα-2 adrenergic receptor agonistThe lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine in low/high doses alone (DL 2.5 μg/kg + 6.25 μg/kg/h; DH 5 μg/kg +12.5 μg/kg/h) or associated with methadone (DLM and DHM, 0.2 mg/kg + 0.05 mg/kg/h) and with low (ACPL 0.02 mg/kg) or high (ACPH 0.09 mg/kg) doses of acepromazine alone. Horses were filmed at (i) baseline (ii) peak, (iii) intermediate, and (iv) end of sedation immediately before auditory, visual and pressure stimuli were applied and postural instability evaluated for another study. Videos were randomized and blindly evaluated by four evaluators in two phases with 1-month interval. Intra- and interobserver reliability of the sum of EquiSed (Intraclass correlation coefficient) ranged between 0.84–0.94 and 0.45–0.88, respectively. The criterion validity was endorsed by the high Spearman correlation between the EquiSed and visual analog (0.77), numerical rating (0.76), and simple descriptive scales (0.70), and average correlation with head height above the ground (HHAG) (−0.52). The Friedman test confirmed the EquiSed responsiveness over time. The principal component analysis showed that all items of the scale had a load factor ≥ 0.50. The item-total Spearman correlation for all items ranged from 0.3 to 0.5, and the internal consistency was good (Cronbach's α = 0.73). The area under the curve of EquiSed HHAG as a predictive diagnostic measure was 0.88. The sensitivity of the EquiSed calculated according to the cut-off point (score 7 of the sum of the EquiSed) determined by the receiver operating characteristic curve, was 96% and specificity was 83%. EquiSed has good intra- and interobserver reliabilities and is valid to evaluate tranquilization and sedation in horses.Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University Universidade Estadual Paulista (UNESP)The Royal (Dick) School of Veterinary Studies and The Roslin Institute The University of EdinburghSection Anaesthesiology Department of Clinical Diagnostics and Services Vetsuisse Faculty University of ZürichDepartment of Surgery and Anaesthesia of Domestic Animals Faculty of Veterinary Medicine Ghent UniversityDepartment of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science São Paulo State University Universidade Estadual Paulista (UNESP)Universidade Estadual Paulista (Unesp)The University of EdinburghUniversity of ZürichGhent UniversityOliveira, Alice Rodrigues de [UNESP]Gozalo-Marcilla, MiguelRinger, Simone KatjaSchauvliege, StijnFonseca, Mariana Werneck [UNESP]Trindade, Pedro Henrique Esteves [UNESP]Puoli Filho, José Nicolau Prospero [UNESP]Luna, Stelio Pacca Loureiro [UNESP]2021-06-25T10:54:23Z2021-06-25T10:54:23Z2021-02-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3389/fvets.2021.611729Frontiers in Veterinary Science, v. 8.2297-1769http://hdl.handle.net/11449/20738910.3389/fvets.2021.6117292-s2.0-85101979443Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFrontiers in Veterinary Scienceinfo:eu-repo/semantics/openAccess2021-10-23T17:04:30Zoai:repositorio.unesp.br:11449/207389Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T17:04:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
title |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
spellingShingle |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) Oliveira, Alice Rodrigues de [UNESP] acepromazine maleate detomidine horses methadone scales α-2 adrenergic receptor agonist |
title_short |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
title_full |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
title_fullStr |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
title_full_unstemmed |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
title_sort |
Development, Validation, and Reliability of a Sedation Scale in Horses (EquiSed) |
author |
Oliveira, Alice Rodrigues de [UNESP] |
author_facet |
Oliveira, Alice Rodrigues de [UNESP] Gozalo-Marcilla, Miguel Ringer, Simone Katja Schauvliege, Stijn Fonseca, Mariana Werneck [UNESP] Trindade, Pedro Henrique Esteves [UNESP] Puoli Filho, José Nicolau Prospero [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
author_role |
author |
author2 |
Gozalo-Marcilla, Miguel Ringer, Simone Katja Schauvliege, Stijn Fonseca, Mariana Werneck [UNESP] Trindade, Pedro Henrique Esteves [UNESP] Puoli Filho, José Nicolau Prospero [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) The University of Edinburgh University of Zürich Ghent University |
dc.contributor.author.fl_str_mv |
Oliveira, Alice Rodrigues de [UNESP] Gozalo-Marcilla, Miguel Ringer, Simone Katja Schauvliege, Stijn Fonseca, Mariana Werneck [UNESP] Trindade, Pedro Henrique Esteves [UNESP] Puoli Filho, José Nicolau Prospero [UNESP] Luna, Stelio Pacca Loureiro [UNESP] |
dc.subject.por.fl_str_mv |
acepromazine maleate detomidine horses methadone scales α-2 adrenergic receptor agonist |
topic |
acepromazine maleate detomidine horses methadone scales α-2 adrenergic receptor agonist |
description |
The lack of standardization of sedation scales in horses limits the reproducibility between different studies. This prospective, randomized, blinded, horizontal and controlled trial aimed to validate a scale for sedation in horses (EquiSed). Seven horses were treated with intravenous detomidine in low/high doses alone (DL 2.5 μg/kg + 6.25 μg/kg/h; DH 5 μg/kg +12.5 μg/kg/h) or associated with methadone (DLM and DHM, 0.2 mg/kg + 0.05 mg/kg/h) and with low (ACPL 0.02 mg/kg) or high (ACPH 0.09 mg/kg) doses of acepromazine alone. Horses were filmed at (i) baseline (ii) peak, (iii) intermediate, and (iv) end of sedation immediately before auditory, visual and pressure stimuli were applied and postural instability evaluated for another study. Videos were randomized and blindly evaluated by four evaluators in two phases with 1-month interval. Intra- and interobserver reliability of the sum of EquiSed (Intraclass correlation coefficient) ranged between 0.84–0.94 and 0.45–0.88, respectively. The criterion validity was endorsed by the high Spearman correlation between the EquiSed and visual analog (0.77), numerical rating (0.76), and simple descriptive scales (0.70), and average correlation with head height above the ground (HHAG) (−0.52). The Friedman test confirmed the EquiSed responsiveness over time. The principal component analysis showed that all items of the scale had a load factor ≥ 0.50. The item-total Spearman correlation for all items ranged from 0.3 to 0.5, and the internal consistency was good (Cronbach's α = 0.73). The area under the curve of EquiSed HHAG as a predictive diagnostic measure was 0.88. The sensitivity of the EquiSed calculated according to the cut-off point (score 7 of the sum of the EquiSed) determined by the receiver operating characteristic curve, was 96% and specificity was 83%. EquiSed has good intra- and interobserver reliabilities and is valid to evaluate tranquilization and sedation in horses. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:54:23Z 2021-06-25T10:54:23Z 2021-02-16 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3389/fvets.2021.611729 Frontiers in Veterinary Science, v. 8. 2297-1769 http://hdl.handle.net/11449/207389 10.3389/fvets.2021.611729 2-s2.0-85101979443 |
url |
http://dx.doi.org/10.3389/fvets.2021.611729 http://hdl.handle.net/11449/207389 |
identifier_str_mv |
Frontiers in Veterinary Science, v. 8. 2297-1769 10.3389/fvets.2021.611729 2-s2.0-85101979443 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Frontiers in Veterinary Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1792961600593854464 |