Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3923/jbs.2006.182.186 http://hdl.handle.net/11449/68736 |
Resumo: | As several structures of the central nervous system are involved in the control of hydromineral and cardiovascular balance we investigated whether the natriorhexigenic and pressor response induced by the injection of ANG II into the 3rd V could be mediated by vasopressinergic and nitrergic system. Male Holtzman rats weighing 200-250 g with cannulae implanted into the 3rd V were used. The drugs were injected in 0.5 μL over 30-60 sec. Controls were injected with a similar volume of 0.15 M NaCl. ANGII increased the water intake vs control. AVPA injected into 3rd V prior to ANGII decreased the dipsogenic effect of ANGII. L-arginine also decreased the water intake induced by ANGII. AVPA plus L-arginine inhibit the water intake induced by ANGII. 7NIT injected prior to ANGII potentiated the dipsogenic effect of ANGII. Pre-treatment with ANGII increased the sodium ingestion vs control. AVPA decreased the ANGII effect in sodium intake. L-arginine also decreased the natriorhexigenic effect of ANGII. The combination of L-arginine and AVPA inhibit the sodium intake induced by ANGII. 7NIT injected prior to ANGII potentiated the sodium intake induced by ANGII. ANGII induced an increase in Mean Arterial Pressure (MAP) vs control. AVPA and L-arginine induced a decreased in the pressor effect of ANGII. The combination of L-arginine and AVPA inhibit the pressor effect of ANGII. 7NIT injected prior to ANGII into 3rd V potentiated the pressor effect of ANGII. These data suggest that arginine vasopressin V 1 receptors and Nitric Oxide (NO) within the circumventricular structures may be involved in sodium intake and pressor response induced by the activation of ANGII receptors within the circumventricular neurons. These studies revealed the involvement of sodium appetite by utilizing the angiotensinergic, vasopressinergic and nitrergic system in the central regulation of blood pressure. © 2006 Asian Network for Scientific Information. |
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Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brainANGII AVP V 1 receptorsCNSNOSodium appetite an blood pressure7 nitroindazoleangiotensin IIangiotensin receptorarginineargipressin receptornitric oxidesodium chloridewateranimal experimentanimal tissueblood pressure regulationbody weightbrain third ventriclecannulacontrolled studyenzyme activationfluid intakeinhibition kineticsmalemean arterial pressurenitrergic nervenonhumanpressor responseratrat strainsodium appetitesodium intakeAnimaliaAs several structures of the central nervous system are involved in the control of hydromineral and cardiovascular balance we investigated whether the natriorhexigenic and pressor response induced by the injection of ANG II into the 3rd V could be mediated by vasopressinergic and nitrergic system. Male Holtzman rats weighing 200-250 g with cannulae implanted into the 3rd V were used. The drugs were injected in 0.5 μL over 30-60 sec. Controls were injected with a similar volume of 0.15 M NaCl. ANGII increased the water intake vs control. AVPA injected into 3rd V prior to ANGII decreased the dipsogenic effect of ANGII. L-arginine also decreased the water intake induced by ANGII. AVPA plus L-arginine inhibit the water intake induced by ANGII. 7NIT injected prior to ANGII potentiated the dipsogenic effect of ANGII. Pre-treatment with ANGII increased the sodium ingestion vs control. AVPA decreased the ANGII effect in sodium intake. L-arginine also decreased the natriorhexigenic effect of ANGII. The combination of L-arginine and AVPA inhibit the sodium intake induced by ANGII. 7NIT injected prior to ANGII potentiated the sodium intake induced by ANGII. ANGII induced an increase in Mean Arterial Pressure (MAP) vs control. AVPA and L-arginine induced a decreased in the pressor effect of ANGII. The combination of L-arginine and AVPA inhibit the pressor effect of ANGII. 7NIT injected prior to ANGII into 3rd V potentiated the pressor effect of ANGII. These data suggest that arginine vasopressin V 1 receptors and Nitric Oxide (NO) within the circumventricular structures may be involved in sodium intake and pressor response induced by the activation of ANGII receptors within the circumventricular neurons. These studies revealed the involvement of sodium appetite by utilizing the angiotensinergic, vasopressinergic and nitrergic system in the central regulation of blood pressure. © 2006 Asian Network for Scientific Information.Department of Exacts and Naturals Sciences, Uiara, Araraquara São PauloInstitute of Bioscience UNITAU, Taubaté, SPDepartment of Physiology and Pathology School of Dentistry UNESP, 1680 Humaitá Street, Araraquara, SP 14801-903Department of Surgery School of Medicine University of São Paulo, São PauloPublic Medical Hospital, São PauloDepartment of Physiology and Pathology School of Dentistry UNESP, 1680 Humaitá Street, Araraquara, SP 14801-903Universidade de Taubaté (UNITAU)Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Saad, Wilson Abrão [UNESP]Guarda, I. F. M. S.Camargo, L. A. D. A. [UNESP]Guarda, R. S.Santos, T. A. F. B. D.2014-05-27T11:21:47Z2014-05-27T11:21:47Z2006-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article182-186http://dx.doi.org/10.3923/jbs.2006.182.186Journal of Biological Sciences, v. 6, n. 1, p. 182-186, 2006.1727-30481812-5719http://hdl.handle.net/11449/6873610.3923/jbs.2006.182.1862-s2.0-33644513409Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Biological Sciences0,1740,174info:eu-repo/semantics/openAccess2021-10-23T11:21:52Zoai:repositorio.unesp.br:11449/68736Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T11:21:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
title |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
spellingShingle |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain Saad, Wilson Abrão [UNESP] ANGII AVP V 1 receptors CNS NO Sodium appetite an blood pressure 7 nitroindazole angiotensin II angiotensin receptor arginine argipressin receptor nitric oxide sodium chloride water animal experiment animal tissue blood pressure regulation body weight brain third ventricle cannula controlled study enzyme activation fluid intake inhibition kinetics male mean arterial pressure nitrergic nerve nonhuman pressor response rat rat strain sodium appetite sodium intake Animalia |
title_short |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
title_full |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
title_fullStr |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
title_full_unstemmed |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
title_sort |
Influence of arginine vasopressin receptor and nitric oxide on the water, sodium intake and arterial blood pressure induce by angiotensin injected into third ventricle of the brain |
author |
Saad, Wilson Abrão [UNESP] |
author_facet |
Saad, Wilson Abrão [UNESP] Guarda, I. F. M. S. Camargo, L. A. D. A. [UNESP] Guarda, R. S. Santos, T. A. F. B. D. |
author_role |
author |
author2 |
Guarda, I. F. M. S. Camargo, L. A. D. A. [UNESP] Guarda, R. S. Santos, T. A. F. B. D. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de Taubaté (UNITAU) Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Saad, Wilson Abrão [UNESP] Guarda, I. F. M. S. Camargo, L. A. D. A. [UNESP] Guarda, R. S. Santos, T. A. F. B. D. |
dc.subject.por.fl_str_mv |
ANGII AVP V 1 receptors CNS NO Sodium appetite an blood pressure 7 nitroindazole angiotensin II angiotensin receptor arginine argipressin receptor nitric oxide sodium chloride water animal experiment animal tissue blood pressure regulation body weight brain third ventricle cannula controlled study enzyme activation fluid intake inhibition kinetics male mean arterial pressure nitrergic nerve nonhuman pressor response rat rat strain sodium appetite sodium intake Animalia |
topic |
ANGII AVP V 1 receptors CNS NO Sodium appetite an blood pressure 7 nitroindazole angiotensin II angiotensin receptor arginine argipressin receptor nitric oxide sodium chloride water animal experiment animal tissue blood pressure regulation body weight brain third ventricle cannula controlled study enzyme activation fluid intake inhibition kinetics male mean arterial pressure nitrergic nerve nonhuman pressor response rat rat strain sodium appetite sodium intake Animalia |
description |
As several structures of the central nervous system are involved in the control of hydromineral and cardiovascular balance we investigated whether the natriorhexigenic and pressor response induced by the injection of ANG II into the 3rd V could be mediated by vasopressinergic and nitrergic system. Male Holtzman rats weighing 200-250 g with cannulae implanted into the 3rd V were used. The drugs were injected in 0.5 μL over 30-60 sec. Controls were injected with a similar volume of 0.15 M NaCl. ANGII increased the water intake vs control. AVPA injected into 3rd V prior to ANGII decreased the dipsogenic effect of ANGII. L-arginine also decreased the water intake induced by ANGII. AVPA plus L-arginine inhibit the water intake induced by ANGII. 7NIT injected prior to ANGII potentiated the dipsogenic effect of ANGII. Pre-treatment with ANGII increased the sodium ingestion vs control. AVPA decreased the ANGII effect in sodium intake. L-arginine also decreased the natriorhexigenic effect of ANGII. The combination of L-arginine and AVPA inhibit the sodium intake induced by ANGII. 7NIT injected prior to ANGII potentiated the sodium intake induced by ANGII. ANGII induced an increase in Mean Arterial Pressure (MAP) vs control. AVPA and L-arginine induced a decreased in the pressor effect of ANGII. The combination of L-arginine and AVPA inhibit the pressor effect of ANGII. 7NIT injected prior to ANGII into 3rd V potentiated the pressor effect of ANGII. These data suggest that arginine vasopressin V 1 receptors and Nitric Oxide (NO) within the circumventricular structures may be involved in sodium intake and pressor response induced by the activation of ANGII receptors within the circumventricular neurons. These studies revealed the involvement of sodium appetite by utilizing the angiotensinergic, vasopressinergic and nitrergic system in the central regulation of blood pressure. © 2006 Asian Network for Scientific Information. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-01-01 2014-05-27T11:21:47Z 2014-05-27T11:21:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3923/jbs.2006.182.186 Journal of Biological Sciences, v. 6, n. 1, p. 182-186, 2006. 1727-3048 1812-5719 http://hdl.handle.net/11449/68736 10.3923/jbs.2006.182.186 2-s2.0-33644513409 |
url |
http://dx.doi.org/10.3923/jbs.2006.182.186 http://hdl.handle.net/11449/68736 |
identifier_str_mv |
Journal of Biological Sciences, v. 6, n. 1, p. 182-186, 2006. 1727-3048 1812-5719 10.3923/jbs.2006.182.186 2-s2.0-33644513409 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Biological Sciences 0,174 0,174 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
182-186 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965220068655104 |