Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1093/mmy/myx080 http://hdl.handle.net/11449/164629 |
Resumo: | A prospective study was performed in 200 paracoccidioidomycosis (PCM) patients, 51 presenting the acute/subacute form (AF) and 149 the chronic form (CF), submitted to the evaluation of the hepatobiliary system at admission and during the follow-up treatment with cotrimoxazole (CMX) or itraconazole (ITC). This study aimed to better evaluate the involvement of the hepatobiliary system in PCM and the effect of these antifungal compounds on this system. Serum levels of direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were evaluated. At admission, all the variables showed changes with elevated values ranging from 6.2% for TB to 32.6% for GGT. After treatment, the incidence of elevated serum levels ranged from 3.6% for DB to 27.5% for ALT. The course of the alterations during the treatment showed regression to normal values in CMX-treated patients and persistence in ITC-treated patients but without the need to discontinue the therapy. Our findings contribute to the knowledge of the hepatobiliary involvement by Paracoccidioides sp. and to a safe follow-up of PCM patients under treatment. |
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Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazoleparacoccidioidomycosishepatobiliarysystemcotrimoxazoleitraconazoleA prospective study was performed in 200 paracoccidioidomycosis (PCM) patients, 51 presenting the acute/subacute form (AF) and 149 the chronic form (CF), submitted to the evaluation of the hepatobiliary system at admission and during the follow-up treatment with cotrimoxazole (CMX) or itraconazole (ITC). This study aimed to better evaluate the involvement of the hepatobiliary system in PCM and the effect of these antifungal compounds on this system. Serum levels of direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were evaluated. At admission, all the variables showed changes with elevated values ranging from 6.2% for TB to 32.6% for GGT. After treatment, the incidence of elevated serum levels ranged from 3.6% for DB to 27.5% for ALT. The course of the alterations during the treatment showed regression to normal values in CMX-treated patients and persistence in ITC-treated patients but without the need to discontinue the therapy. Our findings contribute to the knowledge of the hepatobiliary involvement by Paracoccidioides sp. and to a safe follow-up of PCM patients under treatment.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Sao Paulo State Univ UNESP, Trop Dis Dept, Fac Med Botucatu, Campus Botucatu, Botucatu, SP, BrazilUniv Oeste Paulista, UNOESTE, Presidente Prudente, SP, BrazilInst Biociencias Botucatu UNESP, Botucatu, SP, BrazilSao Paulo State Univ UNESP, Trop Dis Dept, Fac Med Botucatu, Campus Botucatu, Botucatu, SP, BrazilInst Biociencias Botucatu UNESP, Botucatu, SP, BrazilOxford Univ PressUniversidade Estadual Paulista (Unesp)Univ Oeste PaulistaLevorato, Adriele Dandara [UNESP]Moris, Daniela VanessaCavalcante, Ricardo de Souza [UNESP]Sylvestre, Tatiane Fernanda [UNESP]Azevedo, Priscila Zacarias de [UNESP]Carvalho, Lidia Raquel de [UNESP]Mendes, Rinaldo Poncio [UNESP]2018-11-26T17:55:22Z2018-11-26T17:55:22Z2018-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article531-540application/pdfhttp://dx.doi.org/10.1093/mmy/myx080Medical Mycology. Oxford: Oxford Univ Press, v. 56, n. 5, p. 531-540, 2018.1369-3786http://hdl.handle.net/11449/16462910.1093/mmy/myx080WOS:000444346200002WOS000444346200002.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycology0,973info:eu-repo/semantics/openAccess2024-01-07T06:21:39Zoai:repositorio.unesp.br:11449/164629Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-07T06:21:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
title |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
spellingShingle |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole Levorato, Adriele Dandara [UNESP] paracoccidioidomycosis hepatobiliary system cotrimoxazole itraconazole |
title_short |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
title_full |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
title_fullStr |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
title_full_unstemmed |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
title_sort |
Evaluation of the hepatobiliary system in patients with paracoccidioidomycosis treated with cotrimoxazole or itraconazole |
author |
Levorato, Adriele Dandara [UNESP] |
author_facet |
Levorato, Adriele Dandara [UNESP] Moris, Daniela Vanessa Cavalcante, Ricardo de Souza [UNESP] Sylvestre, Tatiane Fernanda [UNESP] Azevedo, Priscila Zacarias de [UNESP] Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] |
author_role |
author |
author2 |
Moris, Daniela Vanessa Cavalcante, Ricardo de Souza [UNESP] Sylvestre, Tatiane Fernanda [UNESP] Azevedo, Priscila Zacarias de [UNESP] Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Univ Oeste Paulista |
dc.contributor.author.fl_str_mv |
Levorato, Adriele Dandara [UNESP] Moris, Daniela Vanessa Cavalcante, Ricardo de Souza [UNESP] Sylvestre, Tatiane Fernanda [UNESP] Azevedo, Priscila Zacarias de [UNESP] Carvalho, Lidia Raquel de [UNESP] Mendes, Rinaldo Poncio [UNESP] |
dc.subject.por.fl_str_mv |
paracoccidioidomycosis hepatobiliary system cotrimoxazole itraconazole |
topic |
paracoccidioidomycosis hepatobiliary system cotrimoxazole itraconazole |
description |
A prospective study was performed in 200 paracoccidioidomycosis (PCM) patients, 51 presenting the acute/subacute form (AF) and 149 the chronic form (CF), submitted to the evaluation of the hepatobiliary system at admission and during the follow-up treatment with cotrimoxazole (CMX) or itraconazole (ITC). This study aimed to better evaluate the involvement of the hepatobiliary system in PCM and the effect of these antifungal compounds on this system. Serum levels of direct bilirubin (DB), total bilirubin (TB), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were evaluated. At admission, all the variables showed changes with elevated values ranging from 6.2% for TB to 32.6% for GGT. After treatment, the incidence of elevated serum levels ranged from 3.6% for DB to 27.5% for ALT. The course of the alterations during the treatment showed regression to normal values in CMX-treated patients and persistence in ITC-treated patients but without the need to discontinue the therapy. Our findings contribute to the knowledge of the hepatobiliary involvement by Paracoccidioides sp. and to a safe follow-up of PCM patients under treatment. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-26T17:55:22Z 2018-11-26T17:55:22Z 2018-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1093/mmy/myx080 Medical Mycology. Oxford: Oxford Univ Press, v. 56, n. 5, p. 531-540, 2018. 1369-3786 http://hdl.handle.net/11449/164629 10.1093/mmy/myx080 WOS:000444346200002 WOS000444346200002.pdf |
url |
http://dx.doi.org/10.1093/mmy/myx080 http://hdl.handle.net/11449/164629 |
identifier_str_mv |
Medical Mycology. Oxford: Oxford Univ Press, v. 56, n. 5, p. 531-540, 2018. 1369-3786 10.1093/mmy/myx080 WOS:000444346200002 WOS000444346200002.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Mycology 0,973 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
531-540 application/pdf |
dc.publisher.none.fl_str_mv |
Oxford Univ Press |
publisher.none.fl_str_mv |
Oxford Univ Press |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797790222909440000 |