A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.pdpdt.2020.102041 http://hdl.handle.net/11449/206657 |
Resumo: | Objective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS). Methodologies: Patients with DS were randomly assigned to the groups: aPDT (n = 30) and nystatin (NYS, n = 35). aPDT patients received 6 aPDT sessions, three times a week for 15 days, which involved PDZ (200 mg/L) topical application (20 min) on the palate and upper denture, followed by LED illumination (660 nm, 50 J/cm²). NYS patients were instructed to rinse one dropper of this medication for one minute, four times a day, for 15 days. Microbiological collections of dentures and palates were performed and cultured on blood agar and CHROMAgar Candida. Microbial viability was determined, and photographs of the palates were taken for clinical evaluation. Data were analyzed by Repeated Measure Linear Model and Bonferroni (p ≤ 0.05). Results: aPDT was more effective to reduce the total microbiota than NYS. At the end of the treatments, aPDT reduced 1.98 from the palate and 1.91 log10 from the denture, while NYS reduced 0.05 and 0.17 log10, respectively. Moreover, aPDT was as effective as NYS to reduce Candida. Reductions of 0.68 and 0.77 log10 were observed in the palate and denture of aPDT group, while reductions of 0.57 and 1.43 log10 were achieved in the NYS group, respectively. Regarding to oral lesion, 53.3 and 54.2 % of the patients from aPDT and NYS groups had clinical improvement. However, the recurrence of DS was observed in both groups. Conclusion: PDZ-mediated aPDT is a promising treatment for DS. |
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A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitisAntimicrobial photochemotherapyAntimicrobial Photodynamic TherapyCandidaOral candidiasisObjective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS). Methodologies: Patients with DS were randomly assigned to the groups: aPDT (n = 30) and nystatin (NYS, n = 35). aPDT patients received 6 aPDT sessions, three times a week for 15 days, which involved PDZ (200 mg/L) topical application (20 min) on the palate and upper denture, followed by LED illumination (660 nm, 50 J/cm²). NYS patients were instructed to rinse one dropper of this medication for one minute, four times a day, for 15 days. Microbiological collections of dentures and palates were performed and cultured on blood agar and CHROMAgar Candida. Microbial viability was determined, and photographs of the palates were taken for clinical evaluation. Data were analyzed by Repeated Measure Linear Model and Bonferroni (p ≤ 0.05). Results: aPDT was more effective to reduce the total microbiota than NYS. At the end of the treatments, aPDT reduced 1.98 from the palate and 1.91 log10 from the denture, while NYS reduced 0.05 and 0.17 log10, respectively. Moreover, aPDT was as effective as NYS to reduce Candida. Reductions of 0.68 and 0.77 log10 were observed in the palate and denture of aPDT group, while reductions of 0.57 and 1.43 log10 were achieved in the NYS group, respectively. Regarding to oral lesion, 53.3 and 54.2 % of the patients from aPDT and NYS groups had clinical improvement. However, the recurrence of DS was observed in both groups. Conclusion: PDZ-mediated aPDT is a promising treatment for DS.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Biophotonics Lab Group of Optics Physics Institute of São Carlos University of São Paulo - USP, Av. Trabalhador São-carlense, 400Department of Dental Materials and Prosthodontics São Paulo State University (Unesp) School of Dentistry, Araraquara, Rua Humaitá, 1680Department of Dental Materials and Prosthodontics São Paulo State University (Unesp) School of Dentistry, Araraquara, Rua Humaitá, 1680FAPESP: 2013/07276-1FAPESP: 2014/01262-1Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Alves, FernandaCarmello, Juliana Cabrini [UNESP]Alonso, Gabriela Caroline [UNESP]Mima, Ewerton Garcia de Oliveira [UNESP]Bagnato, Vanderlei SalvadorPavarina, Ana Cláudia [UNESP]2021-06-25T10:36:02Z2021-06-25T10:36:02Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.pdpdt.2020.102041Photodiagnosis and Photodynamic Therapy, v. 32.1873-15971572-1000http://hdl.handle.net/11449/20665710.1016/j.pdpdt.2020.1020412-s2.0-85092476041Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhotodiagnosis and Photodynamic Therapyinfo:eu-repo/semantics/openAccess2021-10-23T08:32:25Zoai:repositorio.unesp.br:11449/206657Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T08:32:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
title |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
spellingShingle |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis Alves, Fernanda Antimicrobial photochemotherapy Antimicrobial Photodynamic Therapy Candida Oral candidiasis |
title_short |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
title_full |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
title_fullStr |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
title_full_unstemmed |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
title_sort |
A randomized clinical trial evaluating Photodithazine-mediated Antimicrobial Photodynamic Therapy as a treatment for Denture stomatitis |
author |
Alves, Fernanda |
author_facet |
Alves, Fernanda Carmello, Juliana Cabrini [UNESP] Alonso, Gabriela Caroline [UNESP] Mima, Ewerton Garcia de Oliveira [UNESP] Bagnato, Vanderlei Salvador Pavarina, Ana Cláudia [UNESP] |
author_role |
author |
author2 |
Carmello, Juliana Cabrini [UNESP] Alonso, Gabriela Caroline [UNESP] Mima, Ewerton Garcia de Oliveira [UNESP] Bagnato, Vanderlei Salvador Pavarina, Ana Cláudia [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Alves, Fernanda Carmello, Juliana Cabrini [UNESP] Alonso, Gabriela Caroline [UNESP] Mima, Ewerton Garcia de Oliveira [UNESP] Bagnato, Vanderlei Salvador Pavarina, Ana Cláudia [UNESP] |
dc.subject.por.fl_str_mv |
Antimicrobial photochemotherapy Antimicrobial Photodynamic Therapy Candida Oral candidiasis |
topic |
Antimicrobial photochemotherapy Antimicrobial Photodynamic Therapy Candida Oral candidiasis |
description |
Objective: This randomized clinical trial assessed antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) to treat patients with denture stomatitis (DS). Methodologies: Patients with DS were randomly assigned to the groups: aPDT (n = 30) and nystatin (NYS, n = 35). aPDT patients received 6 aPDT sessions, three times a week for 15 days, which involved PDZ (200 mg/L) topical application (20 min) on the palate and upper denture, followed by LED illumination (660 nm, 50 J/cm²). NYS patients were instructed to rinse one dropper of this medication for one minute, four times a day, for 15 days. Microbiological collections of dentures and palates were performed and cultured on blood agar and CHROMAgar Candida. Microbial viability was determined, and photographs of the palates were taken for clinical evaluation. Data were analyzed by Repeated Measure Linear Model and Bonferroni (p ≤ 0.05). Results: aPDT was more effective to reduce the total microbiota than NYS. At the end of the treatments, aPDT reduced 1.98 from the palate and 1.91 log10 from the denture, while NYS reduced 0.05 and 0.17 log10, respectively. Moreover, aPDT was as effective as NYS to reduce Candida. Reductions of 0.68 and 0.77 log10 were observed in the palate and denture of aPDT group, while reductions of 0.57 and 1.43 log10 were achieved in the NYS group, respectively. Regarding to oral lesion, 53.3 and 54.2 % of the patients from aPDT and NYS groups had clinical improvement. However, the recurrence of DS was observed in both groups. Conclusion: PDZ-mediated aPDT is a promising treatment for DS. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 2021-06-25T10:36:02Z 2021-06-25T10:36:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.pdpdt.2020.102041 Photodiagnosis and Photodynamic Therapy, v. 32. 1873-1597 1572-1000 http://hdl.handle.net/11449/206657 10.1016/j.pdpdt.2020.102041 2-s2.0-85092476041 |
url |
http://dx.doi.org/10.1016/j.pdpdt.2020.102041 http://hdl.handle.net/11449/206657 |
identifier_str_mv |
Photodiagnosis and Photodynamic Therapy, v. 32. 1873-1597 1572-1000 10.1016/j.pdpdt.2020.102041 2-s2.0-85092476041 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Photodiagnosis and Photodynamic Therapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1792962398128177152 |