Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.pdpdt.2023.103495 http://hdl.handle.net/11449/248612 |
Resumo: | Antimicrobial photodynamic therapy (aPDT) has been studied as an alternative to combat bacterial resistance to the commonly used antibiotics. aPDT requires the use of a photosensitizer and curcumin is one of the more promising, though the usage of natural curcumin can be inconsistent in certain biomedical uses due to differences in soil condition and turmeric age, besides a large quantity of the plant is necessary to obtain useful amounts of the actual molecule. As such, a synthetic analogue is preferred as it is pure, and its components are better characterized. The present work studied photophysical differences in both natural and synthetic curcumin using photobleaching experiments and searched for whether differences existed in aPDT studies against Staphylococcus aureus. The results showed a faster O2 consumption and a singlet oxygen's generation rate lower by the synthetic curcumin, in comparison with the natural derivative. However, no statistical difference was observed when inactivating S. aureus and these results were following a concentration-based pattern. Thus, the use of synthetic curcumin is indicated, as it can be obtained in controlled amounts and with less environmental impact. Although there are small changes in a photophysical context comparing natural versus synthetic curcumins, we did not observe statistical differences in the photoinactivation of S.aureus bacteria, and reproducibility in biomedical contexts is better achieved with the synthetic analogue. |
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Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluationAntimicrobial photodynamic therapyCurcuminPhotobleachingPhotochemotherapyPhotodynamic therapyAntimicrobial photodynamic therapy (aPDT) has been studied as an alternative to combat bacterial resistance to the commonly used antibiotics. aPDT requires the use of a photosensitizer and curcumin is one of the more promising, though the usage of natural curcumin can be inconsistent in certain biomedical uses due to differences in soil condition and turmeric age, besides a large quantity of the plant is necessary to obtain useful amounts of the actual molecule. As such, a synthetic analogue is preferred as it is pure, and its components are better characterized. The present work studied photophysical differences in both natural and synthetic curcumin using photobleaching experiments and searched for whether differences existed in aPDT studies against Staphylococcus aureus. The results showed a faster O2 consumption and a singlet oxygen's generation rate lower by the synthetic curcumin, in comparison with the natural derivative. However, no statistical difference was observed when inactivating S. aureus and these results were following a concentration-based pattern. Thus, the use of synthetic curcumin is indicated, as it can be obtained in controlled amounts and with less environmental impact. Although there are small changes in a photophysical context comparing natural versus synthetic curcumins, we did not observe statistical differences in the photoinactivation of S.aureus bacteria, and reproducibility in biomedical contexts is better achieved with the synthetic analogue.São Carlos Institute of Physics Group of Optics University of São Paulo, SPAraraquara Dental School Department of Social Dentistry Univ Estadual Paulista, SPHagler Institute for Advanced Studies Texas A&M UniversityAraraquara Dental School Department of Social Dentistry Univ Estadual Paulista, SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Texas A&M UniversityMelo, Nicolas Junhiti deTovar, Johan S.D.Dovigo, Lívia Nordi [UNESP]Dias, Lucas D.Bagnato, Vanderlei SalvadorInada, Natalia Mayumi2023-07-29T13:48:48Z2023-07-29T13:48:48Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.pdpdt.2023.103495Photodiagnosis and Photodynamic Therapy, v. 42.1873-15971572-1000http://hdl.handle.net/11449/24861210.1016/j.pdpdt.2023.1034952-s2.0-85151456964Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPhotodiagnosis and Photodynamic Therapyinfo:eu-repo/semantics/openAccess2023-07-29T13:48:48Zoai:repositorio.unesp.br:11449/248612Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:48:48Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
title |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
spellingShingle |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation Melo, Nicolas Junhiti de Antimicrobial photodynamic therapy Curcumin Photobleaching Photochemotherapy Photodynamic therapy |
title_short |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
title_full |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
title_fullStr |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
title_full_unstemmed |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
title_sort |
Natural versus synthetic curcuminoids as photosensitizers: Photobleaching and antimicrobial photodynamic therapy evaluation |
author |
Melo, Nicolas Junhiti de |
author_facet |
Melo, Nicolas Junhiti de Tovar, Johan S.D. Dovigo, Lívia Nordi [UNESP] Dias, Lucas D. Bagnato, Vanderlei Salvador Inada, Natalia Mayumi |
author_role |
author |
author2 |
Tovar, Johan S.D. Dovigo, Lívia Nordi [UNESP] Dias, Lucas D. Bagnato, Vanderlei Salvador Inada, Natalia Mayumi |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Texas A&M University |
dc.contributor.author.fl_str_mv |
Melo, Nicolas Junhiti de Tovar, Johan S.D. Dovigo, Lívia Nordi [UNESP] Dias, Lucas D. Bagnato, Vanderlei Salvador Inada, Natalia Mayumi |
dc.subject.por.fl_str_mv |
Antimicrobial photodynamic therapy Curcumin Photobleaching Photochemotherapy Photodynamic therapy |
topic |
Antimicrobial photodynamic therapy Curcumin Photobleaching Photochemotherapy Photodynamic therapy |
description |
Antimicrobial photodynamic therapy (aPDT) has been studied as an alternative to combat bacterial resistance to the commonly used antibiotics. aPDT requires the use of a photosensitizer and curcumin is one of the more promising, though the usage of natural curcumin can be inconsistent in certain biomedical uses due to differences in soil condition and turmeric age, besides a large quantity of the plant is necessary to obtain useful amounts of the actual molecule. As such, a synthetic analogue is preferred as it is pure, and its components are better characterized. The present work studied photophysical differences in both natural and synthetic curcumin using photobleaching experiments and searched for whether differences existed in aPDT studies against Staphylococcus aureus. The results showed a faster O2 consumption and a singlet oxygen's generation rate lower by the synthetic curcumin, in comparison with the natural derivative. However, no statistical difference was observed when inactivating S. aureus and these results were following a concentration-based pattern. Thus, the use of synthetic curcumin is indicated, as it can be obtained in controlled amounts and with less environmental impact. Although there are small changes in a photophysical context comparing natural versus synthetic curcumins, we did not observe statistical differences in the photoinactivation of S.aureus bacteria, and reproducibility in biomedical contexts is better achieved with the synthetic analogue. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:48:48Z 2023-07-29T13:48:48Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.pdpdt.2023.103495 Photodiagnosis and Photodynamic Therapy, v. 42. 1873-1597 1572-1000 http://hdl.handle.net/11449/248612 10.1016/j.pdpdt.2023.103495 2-s2.0-85151456964 |
url |
http://dx.doi.org/10.1016/j.pdpdt.2023.103495 http://hdl.handle.net/11449/248612 |
identifier_str_mv |
Photodiagnosis and Photodynamic Therapy, v. 42. 1873-1597 1572-1000 10.1016/j.pdpdt.2023.103495 2-s2.0-85151456964 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Photodiagnosis and Photodynamic Therapy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789761623031808 |