Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

Detalhes bibliográficos
Autor(a) principal: Silva, M. [UNESP]
Data de Publicação: 2001
Outros Autores: Lara, A. S., Leite, C. Q.F. [UNESP], Ferreira, E. I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1002/1521-4184(200106)334:6<189
http://hdl.handle.net/11449/219243
Resumo: With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.
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spelling Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazidCo-polymer poly(ethylene glycol)-poly(aspartic acid)IsoniazidMicelle-forming polymerPotential tuberculostatic agentProdrugWith the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SPFaculdade de Ciências Farmacêuticas Universidade de São Paulo, CP 05508-970Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, CP502, 14801-902, Araraquara - SPUniversidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Silva, M. [UNESP]Lara, A. S.Leite, C. Q.F. [UNESP]Ferreira, E. I.2022-04-28T18:54:32Z2022-04-28T18:54:32Z2001-07-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article189-193http://dx.doi.org/10.1002/1521-4184(200106)334:6<189Archiv der Pharmazie, v. 334, n. 6, p. 189-193, 2001.0365-6233http://hdl.handle.net/11449/21924310.1002/1521-4184(200106)334:6<1892-s2.0-0034952920Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchiv der Pharmazieinfo:eu-repo/semantics/openAccess2022-04-28T18:54:32Zoai:repositorio.unesp.br:11449/219243Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T18:54:32Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
title Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
spellingShingle Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
Silva, M. [UNESP]
Co-polymer poly(ethylene glycol)-poly(aspartic acid)
Isoniazid
Micelle-forming polymer
Potential tuberculostatic agent
Prodrug
title_short Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
title_full Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
title_fullStr Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
title_full_unstemmed Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
title_sort Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid
author Silva, M. [UNESP]
author_facet Silva, M. [UNESP]
Lara, A. S.
Leite, C. Q.F. [UNESP]
Ferreira, E. I.
author_role author
author2 Lara, A. S.
Leite, C. Q.F. [UNESP]
Ferreira, E. I.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Silva, M. [UNESP]
Lara, A. S.
Leite, C. Q.F. [UNESP]
Ferreira, E. I.
dc.subject.por.fl_str_mv Co-polymer poly(ethylene glycol)-poly(aspartic acid)
Isoniazid
Micelle-forming polymer
Potential tuberculostatic agent
Prodrug
topic Co-polymer poly(ethylene glycol)-poly(aspartic acid)
Isoniazid
Micelle-forming polymer
Potential tuberculostatic agent
Prodrug
description With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.
publishDate 2001
dc.date.none.fl_str_mv 2001-07-16
2022-04-28T18:54:32Z
2022-04-28T18:54:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1002/1521-4184(200106)334:6<189
Archiv der Pharmazie, v. 334, n. 6, p. 189-193, 2001.
0365-6233
http://hdl.handle.net/11449/219243
10.1002/1521-4184(200106)334:6<189
2-s2.0-0034952920
url http://dx.doi.org/10.1002/1521-4184(200106)334:6<189
http://hdl.handle.net/11449/219243
identifier_str_mv Archiv der Pharmazie, v. 334, n. 6, p. 189-193, 2001.
0365-6233
10.1002/1521-4184(200106)334:6<189
2-s2.0-0034952920
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Archiv der Pharmazie
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 189-193
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965620404486144

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