pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Vega-Chacón, Jaime [UNESP]
Data de Publicação: 2017
Outros Autores: Arbeláez, María Isabel Amaya [UNESP], Jorge, Janaina Habib [UNESP], Marques, Rodrigo Fernando C. [UNESP], Jafelicci, Miguel [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.msec.2017.03.244
http://hdl.handle.net/11449/169591
Resumo: A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel. The surface modification in each step was confirmed by DRIFTS, TEM and zeta potential measurements. The hydrodynamic diameter of the nanosystems decreases as the pH value decreases. The nanosystems showed high colloidal stability in water and no cytotoxicity was detected, which make these nanosystems suitable for biomedical applications.
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spelling pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applicationsHydrogelMagnetite nanoparticlespH-responsivePoly(aspartic acid)A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel. The surface modification in each step was confirmed by DRIFTS, TEM and zeta potential measurements. The hydrodynamic diameter of the nanosystems decreases as the pH value decreases. The nanosystems showed high colloidal stability in water and no cytotoxicity was detected, which make these nanosystems suitable for biomedical applications.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) Institute of ChemistrySão Paulo State University (UNESP) School of DentistrySão Paulo State University (UNESP) Institute of ChemistrySão Paulo State University (UNESP) School of DentistryUniversidade Estadual Paulista (Unesp)Vega-Chacón, Jaime [UNESP]Arbeláez, María Isabel Amaya [UNESP]Jorge, Janaina Habib [UNESP]Marques, Rodrigo Fernando C. [UNESP]Jafelicci, Miguel [UNESP]2018-12-11T16:46:44Z2018-12-11T16:46:44Z2017-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article366-373application/pdfhttp://dx.doi.org/10.1016/j.msec.2017.03.244Materials Science and Engineering C, v. 77, p. 366-373.0928-4931http://hdl.handle.net/11449/16959110.1016/j.msec.2017.03.2442-s2.0-850164770432-s2.0-85016477043.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science and Engineering C1,110info:eu-repo/semantics/openAccess2023-12-18T06:18:01Zoai:repositorio.unesp.br:11449/169591Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-18T06:18:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
title pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
spellingShingle pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
Vega-Chacón, Jaime [UNESP]
Hydrogel
Magnetite nanoparticles
pH-responsive
Poly(aspartic acid)
title_short pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
title_full pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
title_fullStr pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
title_full_unstemmed pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
title_sort pH-responsive poly(aspartic acid) hydrogel-coated magnetite nanoparticles for biomedical applications
author Vega-Chacón, Jaime [UNESP]
author_facet Vega-Chacón, Jaime [UNESP]
Arbeláez, María Isabel Amaya [UNESP]
Jorge, Janaina Habib [UNESP]
Marques, Rodrigo Fernando C. [UNESP]
Jafelicci, Miguel [UNESP]
author_role author
author2 Arbeláez, María Isabel Amaya [UNESP]
Jorge, Janaina Habib [UNESP]
Marques, Rodrigo Fernando C. [UNESP]
Jafelicci, Miguel [UNESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Vega-Chacón, Jaime [UNESP]
Arbeláez, María Isabel Amaya [UNESP]
Jorge, Janaina Habib [UNESP]
Marques, Rodrigo Fernando C. [UNESP]
Jafelicci, Miguel [UNESP]
dc.subject.por.fl_str_mv Hydrogel
Magnetite nanoparticles
pH-responsive
Poly(aspartic acid)
topic Hydrogel
Magnetite nanoparticles
pH-responsive
Poly(aspartic acid)
description A novel multifunctional nanosystem formed by magnetite nanoparticles coated with pH-responsive poly(aspartic acid) hydrogel was developed. Magnetite nanoparticles (Fe3O4) have been intensively investigated for biomedical applications due to their magnetic properties and dimensions similar to the biostructures. Poly(aspartic acid) is a water-soluble, biodegradable and biocompatible polymer, which features makes it a potential candidate for biomedical applications. The nanoparticles surface modification was carried out by crosslinking polysuccinimide on the magnetite nanoparticles surface and hydrolyzing the succinimide units in mild alkaline medium to obtain the magnetic poly(aspartic acid) hydrogel. The surface modification in each step was confirmed by DRIFTS, TEM and zeta potential measurements. The hydrodynamic diameter of the nanosystems decreases as the pH value decreases. The nanosystems showed high colloidal stability in water and no cytotoxicity was detected, which make these nanosystems suitable for biomedical applications.
publishDate 2017
dc.date.none.fl_str_mv 2017-08-01
2018-12-11T16:46:44Z
2018-12-11T16:46:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.msec.2017.03.244
Materials Science and Engineering C, v. 77, p. 366-373.
0928-4931
http://hdl.handle.net/11449/169591
10.1016/j.msec.2017.03.244
2-s2.0-85016477043
2-s2.0-85016477043.pdf
url http://dx.doi.org/10.1016/j.msec.2017.03.244
http://hdl.handle.net/11449/169591
identifier_str_mv Materials Science and Engineering C, v. 77, p. 366-373.
0928-4931
10.1016/j.msec.2017.03.244
2-s2.0-85016477043
2-s2.0-85016477043.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Materials Science and Engineering C
1,110
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 366-373
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965327708127232

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