Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/230960 |
Resumo: | Objective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 negative group. |
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Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease ProgressionAllelesFollowupHLA-B27SpondyloarthropathiesUndifferentiated spondyloarthropathiesObjective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 negative group.Department of Internal Medicine State University of Campinas Faculty of Medical Sciences, CampinasLaboratory of RheumatologyImmunology Unit State University of Sao Paulo, Ribeirão PretoDepartment of Clinical PathologyHaematology UnitRheumatology UnitDepartment of RheumatologyRheumatology Unit Faculty of Medical Sciences State University of Campinas, CampinasDepartamento de Clinica Medica Faculdade de Ciencias Medicas Univ. Estadua de Campinas (UNICAMP), Campinas SP, CEP 13081-970Universidade Estadual de Campinas (UNICAMP)Laboratory of RheumatologyUniversidade de São Paulo (USP)Haematology UnitRheumatology UnitSampaio-Barros, Percival D.Conde, Roseneide A.Donadi, Eduardo A.Kraemer, Maria Helena S.Persoli, LigiaCoimbra, Ibsen B.Costallat, Lilian Teresa L.Samara, Adil M.Bértolo, Manoel B.2022-04-29T08:42:53Z2022-04-29T08:42:53Z2003-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2632-2637Journal of Rheumatology, v. 30, n. 12, p. 2632-2637, 2003.0315-162Xhttp://hdl.handle.net/11449/2309602-s2.0-0346848790Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Rheumatologyinfo:eu-repo/semantics/openAccess2022-04-29T08:42:53Zoai:repositorio.unesp.br:11449/230960Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:42:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
title |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
spellingShingle |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression Sampaio-Barros, Percival D. Alleles Followup HLA-B27 Spondyloarthropathies Undifferentiated spondyloarthropathies |
title_short |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
title_full |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
title_fullStr |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
title_full_unstemmed |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
title_sort |
Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression |
author |
Sampaio-Barros, Percival D. |
author_facet |
Sampaio-Barros, Percival D. Conde, Roseneide A. Donadi, Eduardo A. Kraemer, Maria Helena S. Persoli, Ligia Coimbra, Ibsen B. Costallat, Lilian Teresa L. Samara, Adil M. Bértolo, Manoel B. |
author_role |
author |
author2 |
Conde, Roseneide A. Donadi, Eduardo A. Kraemer, Maria Helena S. Persoli, Ligia Coimbra, Ibsen B. Costallat, Lilian Teresa L. Samara, Adil M. Bértolo, Manoel B. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Laboratory of Rheumatology Universidade de São Paulo (USP) Haematology Unit Rheumatology Unit |
dc.contributor.author.fl_str_mv |
Sampaio-Barros, Percival D. Conde, Roseneide A. Donadi, Eduardo A. Kraemer, Maria Helena S. Persoli, Ligia Coimbra, Ibsen B. Costallat, Lilian Teresa L. Samara, Adil M. Bértolo, Manoel B. |
dc.subject.por.fl_str_mv |
Alleles Followup HLA-B27 Spondyloarthropathies Undifferentiated spondyloarthropathies |
topic |
Alleles Followup HLA-B27 Spondyloarthropathies Undifferentiated spondyloarthropathies |
description |
Objective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 negative group. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-12-01 2022-04-29T08:42:53Z 2022-04-29T08:42:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Rheumatology, v. 30, n. 12, p. 2632-2637, 2003. 0315-162X http://hdl.handle.net/11449/230960 2-s2.0-0346848790 |
identifier_str_mv |
Journal of Rheumatology, v. 30, n. 12, p. 2632-2637, 2003. 0315-162X 2-s2.0-0346848790 |
url |
http://hdl.handle.net/11449/230960 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Rheumatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2632-2637 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964664048648192 |