Antifungal Activity of Maytenin and Pristimerin
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2012/340787 http://hdl.handle.net/11449/26249 |
Resumo: | Fungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agents Trichophyton rubrum and Trichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plant Maytenus ilicifolia (Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents. |
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Antifungal Activity of Maytenin and PristimerinFungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agents Trichophyton rubrum and Trichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plant Maytenus ilicifolia (Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Pró-Reitoria de Pesquisa da UNESP (PROPe UNESP)UNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, BrazilUNESP, Inst Chem, BR-14800900 Araraquara, SP, BrazilUNESP, Fac Pharmaceut Sci, Dept Clin Anal, Lab Clin Mycol, BR-14801902 Araraquara, SP, BrazilUNESP, Inst Chem, BR-14800900 Araraquara, SP, BrazilHindawi Publishing CorporationUniversidade Estadual Paulista (Unesp)Gullo, Fernanda P. [UNESP]Sardi, Janaina C. O. [UNESP]Santos, Vania A. F. F. M. [UNESP]Sangalli-Leite, Fernanda [UNESP]Pitangui, Nayla S. [UNESP]Rossi, Suelen A. [UNESP]de Paula e Silva, Ana C. A. [UNESP]Soares, Luciana A. [UNESP]Silva, Julhiany F. [UNESP]Oliveira, Haroldo C. [UNESP]Furlan, Maysa [UNESP]Silva, Dulce H. S. [UNESP]Bolzani, Vanderlan da Silva [UNESP]Mendes-Giannini, Maria José Soares [UNESP]Fusco-Almeida, Ana Marisa [UNESP]2014-05-20T14:20:49Z2014-05-20T14:20:49Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article6application/pdfhttp://dx.doi.org/10.1155/2012/340787Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 6, 2012.1741-427Xhttp://hdl.handle.net/11449/2624910.1155/2012/340787WOS:000304986200001WOS000304986200001.pdf470200490423124813080427947868720000-0002-8059-08260000-0002-1516-7765Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEvidence-based Complementary and Alternative Medicine2.064info:eu-repo/semantics/openAccess2023-11-24T06:12:53Zoai:repositorio.unesp.br:11449/26249Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-24T06:12:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antifungal Activity of Maytenin and Pristimerin |
title |
Antifungal Activity of Maytenin and Pristimerin |
spellingShingle |
Antifungal Activity of Maytenin and Pristimerin Gullo, Fernanda P. [UNESP] |
title_short |
Antifungal Activity of Maytenin and Pristimerin |
title_full |
Antifungal Activity of Maytenin and Pristimerin |
title_fullStr |
Antifungal Activity of Maytenin and Pristimerin |
title_full_unstemmed |
Antifungal Activity of Maytenin and Pristimerin |
title_sort |
Antifungal Activity of Maytenin and Pristimerin |
author |
Gullo, Fernanda P. [UNESP] |
author_facet |
Gullo, Fernanda P. [UNESP] Sardi, Janaina C. O. [UNESP] Santos, Vania A. F. F. M. [UNESP] Sangalli-Leite, Fernanda [UNESP] Pitangui, Nayla S. [UNESP] Rossi, Suelen A. [UNESP] de Paula e Silva, Ana C. A. [UNESP] Soares, Luciana A. [UNESP] Silva, Julhiany F. [UNESP] Oliveira, Haroldo C. [UNESP] Furlan, Maysa [UNESP] Silva, Dulce H. S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] |
author_role |
author |
author2 |
Sardi, Janaina C. O. [UNESP] Santos, Vania A. F. F. M. [UNESP] Sangalli-Leite, Fernanda [UNESP] Pitangui, Nayla S. [UNESP] Rossi, Suelen A. [UNESP] de Paula e Silva, Ana C. A. [UNESP] Soares, Luciana A. [UNESP] Silva, Julhiany F. [UNESP] Oliveira, Haroldo C. [UNESP] Furlan, Maysa [UNESP] Silva, Dulce H. S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Gullo, Fernanda P. [UNESP] Sardi, Janaina C. O. [UNESP] Santos, Vania A. F. F. M. [UNESP] Sangalli-Leite, Fernanda [UNESP] Pitangui, Nayla S. [UNESP] Rossi, Suelen A. [UNESP] de Paula e Silva, Ana C. A. [UNESP] Soares, Luciana A. [UNESP] Silva, Julhiany F. [UNESP] Oliveira, Haroldo C. [UNESP] Furlan, Maysa [UNESP] Silva, Dulce H. S. [UNESP] Bolzani, Vanderlan da Silva [UNESP] Mendes-Giannini, Maria José Soares [UNESP] Fusco-Almeida, Ana Marisa [UNESP] |
description |
Fungal infections in humans have increased alarmingly in recent years, particularly in immunocompromised individuals. Among the infections systemic candidiasis, aspergillosis, cryptococcosis, paracoccidioidomycosis, and histoplasmosis mortality are more prevalent and more severe in humans. The current high incidence of dermatophytosis is in humans, especially as the main etiologic agents Trichophyton rubrum and Trichophyton mentagrophytes. Molecules pristimerin and maytenin obtained from the plant Maytenus ilicifolia (Celastraceae) are known to show various pharmacological activities. This study aimed to evaluate the spectrum of antifungal activity of maytenin and pristimerin and their cytotoxicity in human keratinocytes (NOK cells of the oral mucosa). It was concluded that the best spectrum of antifungal activity has been shown to maytenin with MIC varying from 0.12 to 125 mg/L, although it is also active with pristimerin MIC ranging between 0.12 and 250 mg/L. Regarding the toxicity, both showed to have high IC50. The SI showed high pristimerin against some species of fungi, but SI maytenin was above 1.0 for all fungi tested, showing a selective action of fungi. However, when comparing the two substances, maytenin also showed better results. The two molecules can be a possible prototype with a broad spectrum of action for the development of new antifungal agents. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T14:20:49Z 2014-05-20T14:20:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2012/340787 Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 6, 2012. 1741-427X http://hdl.handle.net/11449/26249 10.1155/2012/340787 WOS:000304986200001 WOS000304986200001.pdf 4702004904231248 1308042794786872 0000-0002-8059-0826 0000-0002-1516-7765 |
url |
http://dx.doi.org/10.1155/2012/340787 http://hdl.handle.net/11449/26249 |
identifier_str_mv |
Evidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 6, 2012. 1741-427X 10.1155/2012/340787 WOS:000304986200001 WOS000304986200001.pdf 4702004904231248 1308042794786872 0000-0002-8059-0826 0000-0002-1516-7765 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Evidence-based Complementary and Alternative Medicine 2.064 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
6 application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797789801112403968 |