Updating the role of matrix metalloproteinases in mineralized tissue and related diseases
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/1678-7757-2018-0596 http://hdl.handle.net/11449/183894 |
Resumo: | Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer. |
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Repositório Institucional da UNESP |
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Updating the role of matrix metalloproteinases in mineralized tissue and related diseasesExtracellular matrixMatrix metalloproteinasesBoneVascular calcificationExtracellular vesiclesAbstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer.Universidade de São Paulo Faculdade de Odontologia de Bauru Departamento de Ciências BiológicasUniversidade Estadual Paulista Júlio de Mesquita FilhoUniversidade Estadual Paulista Júlio de Mesquita FilhoFaculdade De Odontologia De Bauru - USPUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Tokuhara, Cintia KazukoSantesso, Mariana RodriguesOliveira, Gabriela Silva Neubern DeVentura, Talita Mendes Da SilvaDoyama, Julio ToshimiZambuzzi, Willian FernandoOliveira, Rodrigo Cardoso De2019-10-03T17:32:09Z2019-10-03T17:32:09Z2019info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article-application/pdfhttp://dx.doi.org/10.1590/1678-7757-2018-0596Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019.1678-7757http://hdl.handle.net/11449/18389410.1590/1678-7757-2018-0596S1678-77572019000100301S1678-77572019000100301.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Applied Oral Scienceinfo:eu-repo/semantics/openAccess2024-04-23T15:23:17Zoai:repositorio.unesp.br:11449/183894Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-23T15:23:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
title |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
spellingShingle |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases Tokuhara, Cintia Kazuko Extracellular matrix Matrix metalloproteinases Bone Vascular calcification Extracellular vesicles |
title_short |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
title_full |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
title_fullStr |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
title_full_unstemmed |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
title_sort |
Updating the role of matrix metalloproteinases in mineralized tissue and related diseases |
author |
Tokuhara, Cintia Kazuko |
author_facet |
Tokuhara, Cintia Kazuko Santesso, Mariana Rodrigues Oliveira, Gabriela Silva Neubern De Ventura, Talita Mendes Da Silva Doyama, Julio Toshimi Zambuzzi, Willian Fernando Oliveira, Rodrigo Cardoso De |
author_role |
author |
author2 |
Santesso, Mariana Rodrigues Oliveira, Gabriela Silva Neubern De Ventura, Talita Mendes Da Silva Doyama, Julio Toshimi Zambuzzi, Willian Fernando Oliveira, Rodrigo Cardoso De |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Tokuhara, Cintia Kazuko Santesso, Mariana Rodrigues Oliveira, Gabriela Silva Neubern De Ventura, Talita Mendes Da Silva Doyama, Julio Toshimi Zambuzzi, Willian Fernando Oliveira, Rodrigo Cardoso De |
dc.subject.por.fl_str_mv |
Extracellular matrix Matrix metalloproteinases Bone Vascular calcification Extracellular vesicles |
topic |
Extracellular matrix Matrix metalloproteinases Bone Vascular calcification Extracellular vesicles |
description |
Abstract Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-03T17:32:09Z 2019-10-03T17:32:09Z 2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/1678-7757-2018-0596 Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019. 1678-7757 http://hdl.handle.net/11449/183894 10.1590/1678-7757-2018-0596 S1678-77572019000100301 S1678-77572019000100301.pdf |
url |
http://dx.doi.org/10.1590/1678-7757-2018-0596 http://hdl.handle.net/11449/183894 |
identifier_str_mv |
Journal of Applied Oral Science. Faculdade De Odontologia De Bauru - USP, v. 27, p. -, 2019. 1678-7757 10.1590/1678-7757-2018-0596 S1678-77572019000100301 S1678-77572019000100301.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Applied Oral Science |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
publisher.none.fl_str_mv |
Faculdade De Odontologia De Bauru - USP |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964806170542080 |