Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5433/1679-0359.2012v33n5p1911 http://hdl.handle.net/11449/11021 |
Resumo: | The formulation of a drug can interfere with its absorption into the circulatory system and may result in changes in the dose required to achieve that particular effect. The aim of this study was to determine the lethal dose 50 (LD 50) and 100 (LD100) of a nanoemulsion of propofol and the lipid emulsion in mice intraperitoneally. One hundred sixty animals weighing 36.47 +/- 4.6g, which were distributed randomly into two groups: NANO and EMU who received propofol 1% in the nanoemulsion and lipid emulsion, respectively, intraperitoneally. Began with a dose of 250mg/kg (n=10) and from this isdecreased or increased the dose until achieving 0 and 100% of deaths in each group thus formed were seven subgroups in NANO (each subgroup n = 10) at doses 200, 250, 325, 350, 400, 425 and 475 mg/kg and in EMU eight subgroups (n= 10 each subset) 250, 325, 350, 400, 425, 475, 525 and 575 mg/kg. In the CONTROL group (n= 10) animals received saline in the largest volume used in the other groups to rule out death by the volume injected. Analysis of LD 50 and LD 100 were obtained by linear regression. The LD 50 was 320, 95 mg / kg and 4243, 51mg / kg and the LD 100 was445.99 mg / kg and 595.31 mg / kg to groups NANO and EMU, respectively. It follows that nanoemulsion is propofol in 25% more potent compared to the lipid emulsionintraperitoneally. |
id |
UNSP_d79b740385914aa9fdac1657fce4e496 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/11021 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongosDetermination of lethal doses 50 and 100 of propofol in lipid emulsion nor nanoemulsion intraperitoneally in miceLethal dosepotencypropofolnanoemulsionmiceThe formulation of a drug can interfere with its absorption into the circulatory system and may result in changes in the dose required to achieve that particular effect. The aim of this study was to determine the lethal dose 50 (LD 50) and 100 (LD100) of a nanoemulsion of propofol and the lipid emulsion in mice intraperitoneally. One hundred sixty animals weighing 36.47 +/- 4.6g, which were distributed randomly into two groups: NANO and EMU who received propofol 1% in the nanoemulsion and lipid emulsion, respectively, intraperitoneally. Began with a dose of 250mg/kg (n=10) and from this isdecreased or increased the dose until achieving 0 and 100% of deaths in each group thus formed were seven subgroups in NANO (each subgroup n = 10) at doses 200, 250, 325, 350, 400, 425 and 475 mg/kg and in EMU eight subgroups (n= 10 each subset) 250, 325, 350, 400, 425, 475, 525 and 575 mg/kg. In the CONTROL group (n= 10) animals received saline in the largest volume used in the other groups to rule out death by the volume injected. Analysis of LD 50 and LD 100 were obtained by linear regression. The LD 50 was 320, 95 mg / kg and 4243, 51mg / kg and the LD 100 was445.99 mg / kg and 595.31 mg / kg to groups NANO and EMU, respectively. It follows that nanoemulsion is propofol in 25% more potent compared to the lipid emulsionintraperitoneally.Univ Estado Santa Catarina, Ctr Ciencias Agrovet, CAV, Programa Pos Grad Ciência Anim,UDESC, Lages, SC, BrazilUniv Estadual Paulista, UNESP, Programa Pos Grad Anestesiol, Fauldade Med Botucatu,FMB, Botucatu, SP, BrazilMed Vet Autonomo, Lages, SC, BrazilUDESC, Ctr Ciencias Agrovet, CAV, Lages, SC, BrazilUniv Estadual Paulista, UNESP, Programa Pos Grad Anestesiol, Fauldade Med Botucatu,FMB, Botucatu, SP, BrazilUniversidade Estadual de Londrina (UEL)Univ Estado Santa CatarinaUniversidade Estadual Paulista (Unesp)Med Vet AutonomoUniversidade do Estado de Santa Catarina (UDESC)Gehrcke, Martielo Ivanda Rosa, Ademir Cassiano [UNESP]Tamanho, Renato Batistade Moraes, Aury NunesOleskovicz, Nilson2014-05-20T13:32:18Z2014-05-20T13:32:18Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1911-1917application/pdfhttp://dx.doi.org/10.5433/1679-0359.2012v33n5p1911Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 5, p. 1911-1917, 2012.1676-546Xhttp://hdl.handle.net/11449/1102110.5433/1679-0359.2012v33n5p1911WOS:000314513900030WOS000314513900030.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporSemina: Ciências Agrárias0.349info:eu-repo/semantics/openAccess2024-01-19T06:31:04Zoai:repositorio.unesp.br:11449/11021Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-19T06:31:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos Determination of lethal doses 50 and 100 of propofol in lipid emulsion nor nanoemulsion intraperitoneally in mice |
title |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
spellingShingle |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos Gehrcke, Martielo Ivan Lethal dose potency propofol nanoemulsion mice |
title_short |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
title_full |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
title_fullStr |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
title_full_unstemmed |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
title_sort |
Determinação das doses letal 50 e 100 do propofol em nanoemulsão ou em emulsão lipídica pela via intraperitoneal em camundongos |
author |
Gehrcke, Martielo Ivan |
author_facet |
Gehrcke, Martielo Ivan da Rosa, Ademir Cassiano [UNESP] Tamanho, Renato Batista de Moraes, Aury Nunes Oleskovicz, Nilson |
author_role |
author |
author2 |
da Rosa, Ademir Cassiano [UNESP] Tamanho, Renato Batista de Moraes, Aury Nunes Oleskovicz, Nilson |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Univ Estado Santa Catarina Universidade Estadual Paulista (Unesp) Med Vet Autonomo Universidade do Estado de Santa Catarina (UDESC) |
dc.contributor.author.fl_str_mv |
Gehrcke, Martielo Ivan da Rosa, Ademir Cassiano [UNESP] Tamanho, Renato Batista de Moraes, Aury Nunes Oleskovicz, Nilson |
dc.subject.por.fl_str_mv |
Lethal dose potency propofol nanoemulsion mice |
topic |
Lethal dose potency propofol nanoemulsion mice |
description |
The formulation of a drug can interfere with its absorption into the circulatory system and may result in changes in the dose required to achieve that particular effect. The aim of this study was to determine the lethal dose 50 (LD 50) and 100 (LD100) of a nanoemulsion of propofol and the lipid emulsion in mice intraperitoneally. One hundred sixty animals weighing 36.47 +/- 4.6g, which were distributed randomly into two groups: NANO and EMU who received propofol 1% in the nanoemulsion and lipid emulsion, respectively, intraperitoneally. Began with a dose of 250mg/kg (n=10) and from this isdecreased or increased the dose until achieving 0 and 100% of deaths in each group thus formed were seven subgroups in NANO (each subgroup n = 10) at doses 200, 250, 325, 350, 400, 425 and 475 mg/kg and in EMU eight subgroups (n= 10 each subset) 250, 325, 350, 400, 425, 475, 525 and 575 mg/kg. In the CONTROL group (n= 10) animals received saline in the largest volume used in the other groups to rule out death by the volume injected. Analysis of LD 50 and LD 100 were obtained by linear regression. The LD 50 was 320, 95 mg / kg and 4243, 51mg / kg and the LD 100 was445.99 mg / kg and 595.31 mg / kg to groups NANO and EMU, respectively. It follows that nanoemulsion is propofol in 25% more potent compared to the lipid emulsionintraperitoneally. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-01-01 2014-05-20T13:32:18Z 2014-05-20T13:32:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5433/1679-0359.2012v33n5p1911 Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 5, p. 1911-1917, 2012. 1676-546X http://hdl.handle.net/11449/11021 10.5433/1679-0359.2012v33n5p1911 WOS:000314513900030 WOS000314513900030.pdf |
url |
http://dx.doi.org/10.5433/1679-0359.2012v33n5p1911 http://hdl.handle.net/11449/11021 |
identifier_str_mv |
Semina-ciencias Agrarias. Londrina: Universidade Estadual de Londrina (UEL), v. 33, n. 5, p. 1911-1917, 2012. 1676-546X 10.5433/1679-0359.2012v33n5p1911 WOS:000314513900030 WOS000314513900030.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Semina: Ciências Agrárias 0.349 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1911-1917 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) |
publisher.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797790338633433088 |