Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.msec.2020.111327 http://hdl.handle.net/11449/202021 |
Resumo: | Polymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3–11 μm) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR. |
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Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regenerationAntimicrobialBioglassCarbon nanotubesGBRPoly (lactic acid)Polymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3–11 μm) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Federal University of São Paulo (UNIFESP), 330 Talim StNational Institute for Space Research (INPE), 1758 dos Astronautas AvenueSão Paulo State University (UNESP) Institute of Science and Technology, 777 Eng. Francisco José Longo AvenueSão Paulo State University (UNESP) Institute of Science and Technology, 777 Eng. Francisco José Longo AvenueCAPES: 001FAPESP: 2015/24659-7CNPq: 23637/2017-1CNPq: 310196/2018-3CNPq: 405675/2018-6Universidade de São Paulo (USP)National Institute for Space Research (INPE)Universidade Estadual Paulista (Unesp)de Moura, Nayara KobaMartins, Eduardo FerreiraOliveira, Rodrigo Luiz Moraes Saldanhade Brito Siqueira, Idália Aparecida WaltrickMachado, João Paulo BarrosEsposito, ElisaAmaral, Suelen Simões [UNESP]de Vasconcellos, Luana Marotta Reis [UNESP]Passador, Fabio Robertode Sousa Trichês, Eliandra2020-12-12T02:47:50Z2020-12-12T02:47:50Z2020-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.msec.2020.111327Materials Science and Engineering C, v. 117.1873-01910928-4931http://hdl.handle.net/11449/20202110.1016/j.msec.2020.1113272-s2.0-85089415277Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science and Engineering Cinfo:eu-repo/semantics/openAccess2021-10-23T04:34:10Zoai:repositorio.unesp.br:11449/202021Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T04:34:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
title |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
spellingShingle |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration de Moura, Nayara Koba Antimicrobial Bioglass Carbon nanotubes GBR Poly (lactic acid) |
title_short |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
title_full |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
title_fullStr |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
title_full_unstemmed |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
title_sort |
Synergistic effect of adding bioglass and carbon nanotubes on poly (lactic acid) porous membranes for guided bone regeneration |
author |
de Moura, Nayara Koba |
author_facet |
de Moura, Nayara Koba Martins, Eduardo Ferreira Oliveira, Rodrigo Luiz Moraes Saldanha de Brito Siqueira, Idália Aparecida Waltrick Machado, João Paulo Barros Esposito, Elisa Amaral, Suelen Simões [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Passador, Fabio Roberto de Sousa Trichês, Eliandra |
author_role |
author |
author2 |
Martins, Eduardo Ferreira Oliveira, Rodrigo Luiz Moraes Saldanha de Brito Siqueira, Idália Aparecida Waltrick Machado, João Paulo Barros Esposito, Elisa Amaral, Suelen Simões [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Passador, Fabio Roberto de Sousa Trichês, Eliandra |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) National Institute for Space Research (INPE) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
de Moura, Nayara Koba Martins, Eduardo Ferreira Oliveira, Rodrigo Luiz Moraes Saldanha de Brito Siqueira, Idália Aparecida Waltrick Machado, João Paulo Barros Esposito, Elisa Amaral, Suelen Simões [UNESP] de Vasconcellos, Luana Marotta Reis [UNESP] Passador, Fabio Roberto de Sousa Trichês, Eliandra |
dc.subject.por.fl_str_mv |
Antimicrobial Bioglass Carbon nanotubes GBR Poly (lactic acid) |
topic |
Antimicrobial Bioglass Carbon nanotubes GBR Poly (lactic acid) |
description |
Polymer membranes have been widely used in guided bone regeneration (GBR), especially when it comes to their use in dentistry. Poly (lactic acid) (PLA) have good mechanical properties such as flexibility, which allows the material to be moldable and also has biocompatibility and biodegradation. Besides that, bioglass (BG) incorporated into the polymer matrix can promote osteoinduction properties and osteoconduction properties to the polymer-ceramic biocomposite. The membranes are also required to exhibit antimicrobial activity to prevent or control the proliferation of pathogenic microorganisms, and the addition of carbon nanotubes (CNT) can assist in this property. The porous membranes of PLA with the addition of different contents of BG and CNT were obtained by solvent casting in controlled humidity method, and the synergistic effect of the addition of both fillers were investigated. The membranes showed pores (3–11 μm) on their surface. The addition of 5 wt% BG causes an increase in the surface porosity and bioactivity properties of the PLA. The agar diffusion test showed antimicrobial activity in the membranes with addition of CNT. In vitro results showed that the porous membranes were not cytotoxic and allowed cell activity and differentiation. Thus, BG collaborated to increase biological activity while CNT contributed to microbial activity, creating a synergistic effect on PLA porous membranes, being this effect more evident for PLA/5BG/1.0CNT. These results indicated a promising use of this new biomaterial for the production of porous membranes for GBR. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:47:50Z 2020-12-12T02:47:50Z 2020-12-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.msec.2020.111327 Materials Science and Engineering C, v. 117. 1873-0191 0928-4931 http://hdl.handle.net/11449/202021 10.1016/j.msec.2020.111327 2-s2.0-85089415277 |
url |
http://dx.doi.org/10.1016/j.msec.2020.111327 http://hdl.handle.net/11449/202021 |
identifier_str_mv |
Materials Science and Engineering C, v. 117. 1873-0191 0928-4931 10.1016/j.msec.2020.111327 2-s2.0-85089415277 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Science and Engineering C |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965379281289216 |