Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3390/jcm11216581 http://hdl.handle.net/11449/247854 |
Resumo: | Background: Brazil has the world’s largest public organ transplant program, which was severely affected by the COVID-19 pandemic. The primary aim of the study was to evaluate differences in solid organ transplants and rejection episodes during the COVID-19 pandemic compared to the five years before the pandemic in the country. Methods: A seven-year database was built by downloading data from the DATASUS server. The pandemic period was defined as March 2020 to December 2021. The pre-pandemic period was from January 2015 to March 2020. Results: During the pandemic, the number of solid organ transplants decreased by 19.3% in 2020 and 22.6% in 2021 compared to 2019. We found a decrease for each evaluated organ, which was more pronounced for lung, pancreas, and kidney transplants. The seasonal plot of rejection data indicated a high rejection rate between 2018 and 2021. There was also an 18% (IRR 1.18 (95% CI 1.01 to 1.37), p = 0.04) increase in the rejection rate during the COVID-19 pandemic. Conclusions: The total number of organ transplants performed in 2021 represents a setback of six years. Transplant procedures were concentrated in the Southeast region of the country, and a higher proportion of rejections occurred during the pandemic. Together, these findings could have an impact on transplant procedures and outcomes in Brazil. |
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Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare SystemBrazilCOVID-19graft rejectionorgan transplantBackground: Brazil has the world’s largest public organ transplant program, which was severely affected by the COVID-19 pandemic. The primary aim of the study was to evaluate differences in solid organ transplants and rejection episodes during the COVID-19 pandemic compared to the five years before the pandemic in the country. Methods: A seven-year database was built by downloading data from the DATASUS server. The pandemic period was defined as March 2020 to December 2021. The pre-pandemic period was from January 2015 to March 2020. Results: During the pandemic, the number of solid organ transplants decreased by 19.3% in 2020 and 22.6% in 2021 compared to 2019. We found a decrease for each evaluated organ, which was more pronounced for lung, pancreas, and kidney transplants. The seasonal plot of rejection data indicated a high rejection rate between 2018 and 2021. There was also an 18% (IRR 1.18 (95% CI 1.01 to 1.37), p = 0.04) increase in the rejection rate during the COVID-19 pandemic. Conclusions: The total number of organ transplants performed in 2021 represents a setback of six years. Transplant procedures were concentrated in the Southeast region of the country, and a higher proportion of rejections occurred during the pandemic. Together, these findings could have an impact on transplant procedures and outcomes in Brazil.Department of Internal Medicine—UNESP Univ Estadual Paulista, Av. Prof. Montenegro—Distrito de, Rubião Jr., s/n, SPHealth Technology Assessment Center Hospital das Clínicas—HCFMB, SPTransplant Unit—Santa Casa Juiz de Fora, Av. Barão do Rio Branco, 3353-Passos, MGDepartment of Internal Medicine—UNESP Univ Estadual Paulista, Av. Prof. Montenegro—Distrito de, Rubião Jr., s/n, SPUniversidade Estadual Paulista (UNESP)Health Technology Assessment Center Hospital das Clínicas—HCFMBTransplant Unit—Santa Casa Juiz de Forade Andrade, Luis Gustavo Modelli [UNESP]Barbosa, Abner Macola Pacheco [UNESP]da Rocha, Naila Camila [UNESP]de Almeida Cardoso, Marilia Mastrocollade Almeida, Juliana Tereza ConeglianMachado-Rugolo, JulianaArantes, Lucas FredericoPontes, Daniela Ferreira Salomão [UNESP]Ferreira, Gustavo Fernandes2023-07-29T13:27:45Z2023-07-29T13:27:45Z2022-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.3390/jcm11216581Journal of Clinical Medicine, v. 11, n. 21, 2022.2077-0383http://hdl.handle.net/11449/24785410.3390/jcm112165812-s2.0-85141673944Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Clinical Medicineinfo:eu-repo/semantics/openAccess2023-07-29T13:27:45Zoai:repositorio.unesp.br:11449/247854Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:27:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
title |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
spellingShingle |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System de Andrade, Luis Gustavo Modelli [UNESP] Brazil COVID-19 graft rejection organ transplant |
title_short |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
title_full |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
title_fullStr |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
title_full_unstemmed |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
title_sort |
Impact of the COVID-19 Pandemic on Solid Organ Transplant and Rejection Episodes in Brazil’s Unified Healthcare System |
author |
de Andrade, Luis Gustavo Modelli [UNESP] |
author_facet |
de Andrade, Luis Gustavo Modelli [UNESP] Barbosa, Abner Macola Pacheco [UNESP] da Rocha, Naila Camila [UNESP] de Almeida Cardoso, Marilia Mastrocolla de Almeida, Juliana Tereza Coneglian Machado-Rugolo, Juliana Arantes, Lucas Frederico Pontes, Daniela Ferreira Salomão [UNESP] Ferreira, Gustavo Fernandes |
author_role |
author |
author2 |
Barbosa, Abner Macola Pacheco [UNESP] da Rocha, Naila Camila [UNESP] de Almeida Cardoso, Marilia Mastrocolla de Almeida, Juliana Tereza Coneglian Machado-Rugolo, Juliana Arantes, Lucas Frederico Pontes, Daniela Ferreira Salomão [UNESP] Ferreira, Gustavo Fernandes |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Health Technology Assessment Center Hospital das Clínicas—HCFMB Transplant Unit—Santa Casa Juiz de Fora |
dc.contributor.author.fl_str_mv |
de Andrade, Luis Gustavo Modelli [UNESP] Barbosa, Abner Macola Pacheco [UNESP] da Rocha, Naila Camila [UNESP] de Almeida Cardoso, Marilia Mastrocolla de Almeida, Juliana Tereza Coneglian Machado-Rugolo, Juliana Arantes, Lucas Frederico Pontes, Daniela Ferreira Salomão [UNESP] Ferreira, Gustavo Fernandes |
dc.subject.por.fl_str_mv |
Brazil COVID-19 graft rejection organ transplant |
topic |
Brazil COVID-19 graft rejection organ transplant |
description |
Background: Brazil has the world’s largest public organ transplant program, which was severely affected by the COVID-19 pandemic. The primary aim of the study was to evaluate differences in solid organ transplants and rejection episodes during the COVID-19 pandemic compared to the five years before the pandemic in the country. Methods: A seven-year database was built by downloading data from the DATASUS server. The pandemic period was defined as March 2020 to December 2021. The pre-pandemic period was from January 2015 to March 2020. Results: During the pandemic, the number of solid organ transplants decreased by 19.3% in 2020 and 22.6% in 2021 compared to 2019. We found a decrease for each evaluated organ, which was more pronounced for lung, pancreas, and kidney transplants. The seasonal plot of rejection data indicated a high rejection rate between 2018 and 2021. There was also an 18% (IRR 1.18 (95% CI 1.01 to 1.37), p = 0.04) increase in the rejection rate during the COVID-19 pandemic. Conclusions: The total number of organ transplants performed in 2021 represents a setback of six years. Transplant procedures were concentrated in the Southeast region of the country, and a higher proportion of rejections occurred during the pandemic. Together, these findings could have an impact on transplant procedures and outcomes in Brazil. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-11-01 2023-07-29T13:27:45Z 2023-07-29T13:27:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3390/jcm11216581 Journal of Clinical Medicine, v. 11, n. 21, 2022. 2077-0383 http://hdl.handle.net/11449/247854 10.3390/jcm11216581 2-s2.0-85141673944 |
url |
http://dx.doi.org/10.3390/jcm11216581 http://hdl.handle.net/11449/247854 |
identifier_str_mv |
Journal of Clinical Medicine, v. 11, n. 21, 2022. 2077-0383 10.3390/jcm11216581 2-s2.0-85141673944 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Clinical Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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