Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils
Main Author: | |
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Publication Date: | 2018 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNESP |
Download full: | http://dx.doi.org/10.1016/j.fitote.2017.11.003 http://hdl.handle.net/11449/175482 |
Summary: | Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin or to testosterone cypionate from postnatal day 15 to 42. Male and female gerbils were euthanized at either 43 days or 90 days age. The prostates were collected for biometrical, morphological and immunohistochemical analysis. The results showed that prepubertal exposure to chrysin had differential effects on the prostate of both pubertal and adult animals. The prostates of male and female pubertal gerbils showed no histological alterations, although there was increased frequency of androgen receptor (AR) in males and females, and estrogen receptor alpha (ERα) in females. Adult males and females presented developed prostate glands, with higher cell proliferative rate. In addition, AR and ERα frequency remained high in the prostate of adult animals. These results demonstrated that prepubertal exposure to chrysin disrupts steroid receptors regulation in the prostate, potentiating the response of this gland to the biological effects of endogenous steroids. In this context, excessive consumption of phytoestrogens during the critical stages of development should be considered with caution. |
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Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbilsFemale prostateFlavonoidsGerbilReproductionVentral prostateChrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin or to testosterone cypionate from postnatal day 15 to 42. Male and female gerbils were euthanized at either 43 days or 90 days age. The prostates were collected for biometrical, morphological and immunohistochemical analysis. The results showed that prepubertal exposure to chrysin had differential effects on the prostate of both pubertal and adult animals. The prostates of male and female pubertal gerbils showed no histological alterations, although there was increased frequency of androgen receptor (AR) in males and females, and estrogen receptor alpha (ERα) in females. Adult males and females presented developed prostate glands, with higher cell proliferative rate. In addition, AR and ERα frequency remained high in the prostate of adult animals. These results demonstrated that prepubertal exposure to chrysin disrupts steroid receptors regulation in the prostate, potentiating the response of this gland to the biological effects of endogenous steroids. In this context, excessive consumption of phytoestrogens during the critical stages of development should be considered with caution.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Histology Embryology and Cell Biology Laboratory of Histophysiology Institute of Biological Sciences Federal University of GoiásDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP, Rua Cristóvão Colombo, 2265Department of Chemistry and Environmental Sciences Laboratory of Green and Medicinal Chemistry Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265Special Academic Unit of Health Sciences Medicine Course Federal University of GoiásDepartment of Biology Laboratory of Microscopy and Microanalysis State University of São Paulo – UNESP, Rua Cristóvão Colombo, 2265Department of Chemistry and Environmental Sciences Laboratory of Green and Medicinal Chemistry Institute of Biosciences Humanities and Exact Sciences (Ibilce) São Paulo State University (Unesp), Rua Cristóvão Colombo, 2265FAPESP: 2014/18330-0Universidade Federal de Goiás (UFG)Universidade Estadual Paulista (Unesp)Ribeiro, Naiara C.S.Campos, Mônica S. [UNESP]Santos, Mariana B. [UNESP]Ayusso, Gabriela M. [UNESP]Vilamaior, Patrícia S.L. [UNESP]Regasini, Luis O. [UNESP]Taboga, Sebastião R. [UNESP]Biancardi, Manoel F.Perez, Ana P.S.Santos, Fernanda C.A.2018-12-11T17:16:00Z2018-12-11T17:16:00Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article137-144application/pdfhttp://dx.doi.org/10.1016/j.fitote.2017.11.003Fitoterapia, v. 124, p. 137-144.1873-69710367-326Xhttp://hdl.handle.net/11449/17548210.1016/j.fitote.2017.11.0032-s2.0-850337712702-s2.0-85033771270.pdf70663581237904340000-0001-9559-5497Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFitoterapiainfo:eu-repo/semantics/openAccess2024-04-11T19:33:57Zoai:repositorio.unesp.br:11449/175482Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T19:33:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
title |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
spellingShingle |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils Ribeiro, Naiara C.S. Female prostate Flavonoids Gerbil Reproduction Ventral prostate |
title_short |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
title_full |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
title_fullStr |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
title_full_unstemmed |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
title_sort |
Prepubertal chrysin exposure upregulates either AR in male ventral prostate or AR and ERα in Skene's paraurethral gland of pubertal and adult gerbils |
author |
Ribeiro, Naiara C.S. |
author_facet |
Ribeiro, Naiara C.S. Campos, Mônica S. [UNESP] Santos, Mariana B. [UNESP] Ayusso, Gabriela M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Regasini, Luis O. [UNESP] Taboga, Sebastião R. [UNESP] Biancardi, Manoel F. Perez, Ana P.S. Santos, Fernanda C.A. |
author_role |
author |
author2 |
Campos, Mônica S. [UNESP] Santos, Mariana B. [UNESP] Ayusso, Gabriela M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Regasini, Luis O. [UNESP] Taboga, Sebastião R. [UNESP] Biancardi, Manoel F. Perez, Ana P.S. Santos, Fernanda C.A. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Goiás (UFG) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ribeiro, Naiara C.S. Campos, Mônica S. [UNESP] Santos, Mariana B. [UNESP] Ayusso, Gabriela M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Regasini, Luis O. [UNESP] Taboga, Sebastião R. [UNESP] Biancardi, Manoel F. Perez, Ana P.S. Santos, Fernanda C.A. |
dc.subject.por.fl_str_mv |
Female prostate Flavonoids Gerbil Reproduction Ventral prostate |
topic |
Female prostate Flavonoids Gerbil Reproduction Ventral prostate |
description |
Chrysin is a plant-derived polyphenol that has the potential to increase endogenous testosterone levels both by inhibiting the aromatase enzyme and by stimulating testicular steroidogenesis. The effects of chrysin on the prostate are unknown, especially during its development and functional maturation. Thus, the aim of this study was to evaluate the effects of chrysin prepubertal exposure on the male and female prostates of both pubertal and adult gerbils. To evaluate the possible androgenic responses of chrysin, gerbils were also exposed to testosterone. Male and female gerbils were exposed to chrysin or to testosterone cypionate from postnatal day 15 to 42. Male and female gerbils were euthanized at either 43 days or 90 days age. The prostates were collected for biometrical, morphological and immunohistochemical analysis. The results showed that prepubertal exposure to chrysin had differential effects on the prostate of both pubertal and adult animals. The prostates of male and female pubertal gerbils showed no histological alterations, although there was increased frequency of androgen receptor (AR) in males and females, and estrogen receptor alpha (ERα) in females. Adult males and females presented developed prostate glands, with higher cell proliferative rate. In addition, AR and ERα frequency remained high in the prostate of adult animals. These results demonstrated that prepubertal exposure to chrysin disrupts steroid receptors regulation in the prostate, potentiating the response of this gland to the biological effects of endogenous steroids. In this context, excessive consumption of phytoestrogens during the critical stages of development should be considered with caution. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:16:00Z 2018-12-11T17:16:00Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.fitote.2017.11.003 Fitoterapia, v. 124, p. 137-144. 1873-6971 0367-326X http://hdl.handle.net/11449/175482 10.1016/j.fitote.2017.11.003 2-s2.0-85033771270 2-s2.0-85033771270.pdf 7066358123790434 0000-0001-9559-5497 |
url |
http://dx.doi.org/10.1016/j.fitote.2017.11.003 http://hdl.handle.net/11449/175482 |
identifier_str_mv |
Fitoterapia, v. 124, p. 137-144. 1873-6971 0367-326X 10.1016/j.fitote.2017.11.003 2-s2.0-85033771270 2-s2.0-85033771270.pdf 7066358123790434 0000-0001-9559-5497 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fitoterapia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
137-144 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1797790306091925504 |