Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts

Detalhes bibliográficos
Autor(a) principal: Ruiz, Patrícia Alvarez
Data de Publicação: 2010
Outros Autores: Toledo, Orlando Ayrton de, Nonaka, Cassiano francisco Weege, Pinto, Leão Pereira, Souza, Lélia Batista de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of applied oral science (Online)
Texto Completo: https://www.revistas.usp.br/jaos/article/view/3853
Resumo: OBJECTIVE: This study assessed and compared the immunoexpression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in radicular cysts (RCs) and residual radicular cysts (RRCs), relating them to the angiogenic index and the intensity of the inflammatory infiltrate. MATERIAL AND METHODS: Twenty RCs and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF and anti-MMP-9 antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The expression of both VEGF and MMP-9 was higher in RCs than in RRCs. RCs and RRCs presented strong epithelial expression of VEGF, irrespective of the intensity of the inflammatory infiltrate. Lesions with strong expression of MMP-9 showed significantly higher number of immunopositive cells for VEGF (p
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spelling Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts Matrix metalloproteinase 9Vascular endothelial growth factorsvon Willebrand factorRadicular cystInflammation OBJECTIVE: This study assessed and compared the immunoexpression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in radicular cysts (RCs) and residual radicular cysts (RRCs), relating them to the angiogenic index and the intensity of the inflammatory infiltrate. MATERIAL AND METHODS: Twenty RCs and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF and anti-MMP-9 antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The expression of both VEGF and MMP-9 was higher in RCs than in RRCs. RCs and RRCs presented strong epithelial expression of VEGF, irrespective of the intensity of the inflammatory infiltrate. Lesions with strong expression of MMP-9 showed significantly higher number of immunopositive cells for VEGF (pUniversidade de São Paulo. Faculdade de Odontologia de Bauru2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/jaos/article/view/385310.1590/S1678-77572010000600013Journal of Applied Oral Science; Vol. 18 No. 6 (2010); 613-620 Journal of Applied Oral Science; Vol. 18 Núm. 6 (2010); 613-620 Journal of Applied Oral Science; v. 18 n. 6 (2010); 613-620 1678-77651678-7757reponame:Journal of applied oral science (Online)instname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/jaos/article/view/3853/4543Copyright (c) 2010 Journal of Applied Oral Scienceinfo:eu-repo/semantics/openAccessRuiz, Patrícia AlvarezToledo, Orlando Ayrton deNonaka, Cassiano francisco WeegePinto, Leão PereiraSouza, Lélia Batista de2012-04-27T12:11:43Zoai:revistas.usp.br:article/3853Revistahttp://www.scielo.br/jaosPUBhttps://www.revistas.usp.br/jaos/oai||jaos@usp.br1678-77651678-7757opendoar:2012-04-27T12:11:43Journal of applied oral science (Online) - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
title Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
spellingShingle Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
Ruiz, Patrícia Alvarez
Matrix metalloproteinase 9
Vascular endothelial growth factors
von Willebrand factor
Radicular cyst
Inflammation
title_short Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
title_full Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
title_fullStr Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
title_full_unstemmed Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
title_sort Immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in radicular and residual radicular cysts
author Ruiz, Patrícia Alvarez
author_facet Ruiz, Patrícia Alvarez
Toledo, Orlando Ayrton de
Nonaka, Cassiano francisco Weege
Pinto, Leão Pereira
Souza, Lélia Batista de
author_role author
author2 Toledo, Orlando Ayrton de
Nonaka, Cassiano francisco Weege
Pinto, Leão Pereira
Souza, Lélia Batista de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ruiz, Patrícia Alvarez
Toledo, Orlando Ayrton de
Nonaka, Cassiano francisco Weege
Pinto, Leão Pereira
Souza, Lélia Batista de
dc.subject.por.fl_str_mv Matrix metalloproteinase 9
Vascular endothelial growth factors
von Willebrand factor
Radicular cyst
Inflammation
topic Matrix metalloproteinase 9
Vascular endothelial growth factors
von Willebrand factor
Radicular cyst
Inflammation
description OBJECTIVE: This study assessed and compared the immunoexpression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in radicular cysts (RCs) and residual radicular cysts (RRCs), relating them to the angiogenic index and the intensity of the inflammatory infiltrate. MATERIAL AND METHODS: Twenty RCs and 10 RRCs were evaluated by immunohistochemistry using anti-VEGF and anti-MMP-9 antibodies. The angiogenic index was determined by microvessel count (MVC) using anti-von Willebrand factor antibody. RESULTS: The expression of both VEGF and MMP-9 was higher in RCs than in RRCs. RCs and RRCs presented strong epithelial expression of VEGF, irrespective of the intensity of the inflammatory infiltrate. Lesions with strong expression of MMP-9 showed significantly higher number of immunopositive cells for VEGF (p
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3853
10.1590/S1678-77572010000600013
url https://www.revistas.usp.br/jaos/article/view/3853
identifier_str_mv 10.1590/S1678-77572010000600013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/jaos/article/view/3853/4543
dc.rights.driver.fl_str_mv Copyright (c) 2010 Journal of Applied Oral Science
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2010 Journal of Applied Oral Science
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Odontologia de Bauru
dc.source.none.fl_str_mv Journal of Applied Oral Science; Vol. 18 No. 6 (2010); 613-620
Journal of Applied Oral Science; Vol. 18 Núm. 6 (2010); 613-620
Journal of Applied Oral Science; v. 18 n. 6 (2010); 613-620
1678-7765
1678-7757
reponame:Journal of applied oral science (Online)
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Journal of applied oral science (Online)
collection Journal of applied oral science (Online)
repository.name.fl_str_mv Journal of applied oral science (Online) - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||jaos@usp.br
_version_ 1800221676138397696

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