Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/117964 |
Resumo: | OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma. |
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oai:revistas.usp.br:article/117964 |
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USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/11796410.6061/clinics/2016(06)05Clinics; Vol. 71 No. 6 (2016); 315-319Clinics; v. 71 n. 6 (2016); 315-319Clinics; Vol. 71 Núm. 6 (2016); 315-3191980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/117964/115608Copyright (c) 2016 Clinicsinfo:eu-repo/semantics/openAccessJureidini, Ricardoda Cunha, José Eduardo MonteiroTakeda, FlavioNamur, Guilherme NaccacheRibeiro, Thiago CostaPatzina, RoselyFigueira, Estela RRRibeiro Jr, UlyssesBacchella, TelesforoCecconello, Ivan2016-07-19T19:47:01Zoai:revistas.usp.br:article/117964Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2016-07-19T19:47:01Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
title |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
spellingShingle |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma Jureidini, Ricardo |
title_short |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
title_full |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
title_fullStr |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
title_full_unstemmed |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
title_sort |
Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma |
author |
Jureidini, Ricardo |
author_facet |
Jureidini, Ricardo da Cunha, José Eduardo Monteiro Takeda, Flavio Namur, Guilherme Naccache Ribeiro, Thiago Costa Patzina, Rosely Figueira, Estela RR Ribeiro Jr, Ulysses Bacchella, Telesforo Cecconello, Ivan |
author_role |
author |
author2 |
da Cunha, José Eduardo Monteiro Takeda, Flavio Namur, Guilherme Naccache Ribeiro, Thiago Costa Patzina, Rosely Figueira, Estela RR Ribeiro Jr, Ulysses Bacchella, Telesforo Cecconello, Ivan |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Jureidini, Ricardo da Cunha, José Eduardo Monteiro Takeda, Flavio Namur, Guilherme Naccache Ribeiro, Thiago Costa Patzina, Rosely Figueira, Estela RR Ribeiro Jr, Ulysses Bacchella, Telesforo Cecconello, Ivan |
description |
OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/117964 10.6061/clinics/2016(06)05 |
url |
https://www.revistas.usp.br/clinics/article/view/117964 |
identifier_str_mv |
10.6061/clinics/2016(06)05 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/117964/115608 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 71 No. 6 (2016); 315-319 Clinics; v. 71 n. 6 (2016); 315-319 Clinics; Vol. 71 Núm. 6 (2016); 315-319 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222762628808704 |