Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Jureidini, Ricardo
Data de Publicação: 2016
Outros Autores: da Cunha, José Eduardo Monteiro, Takeda, Flavio, Namur, Guilherme Naccache, Ribeiro, Thiago Costa, Patzina, Rosely, Figueira, Estela RR, Ribeiro Jr, Ulysses, Bacchella, Telesforo, Cecconello, Ivan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/117964
Resumo: OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
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spelling Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/11796410.6061/clinics/2016(06)05Clinics; Vol. 71 No. 6 (2016); 315-319Clinics; v. 71 n. 6 (2016); 315-319Clinics; Vol. 71 Núm. 6 (2016); 315-3191980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/117964/115608Copyright (c) 2016 Clinicsinfo:eu-repo/semantics/openAccessJureidini, Ricardoda Cunha, José Eduardo MonteiroTakeda, FlavioNamur, Guilherme NaccacheRibeiro, Thiago CostaPatzina, RoselyFigueira, Estela RRRibeiro Jr, UlyssesBacchella, TelesforoCecconello, Ivan2016-07-19T19:47:01Zoai:revistas.usp.br:article/117964Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2016-07-19T19:47:01Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
title Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
spellingShingle Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
Jureidini, Ricardo
title_short Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
title_full Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
title_fullStr Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
title_full_unstemmed Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
title_sort Evaluation of microvessel density and p53 expression in pancreatic adenocarcinoma
author Jureidini, Ricardo
author_facet Jureidini, Ricardo
da Cunha, José Eduardo Monteiro
Takeda, Flavio
Namur, Guilherme Naccache
Ribeiro, Thiago Costa
Patzina, Rosely
Figueira, Estela RR
Ribeiro Jr, Ulysses
Bacchella, Telesforo
Cecconello, Ivan
author_role author
author2 da Cunha, José Eduardo Monteiro
Takeda, Flavio
Namur, Guilherme Naccache
Ribeiro, Thiago Costa
Patzina, Rosely
Figueira, Estela RR
Ribeiro Jr, Ulysses
Bacchella, Telesforo
Cecconello, Ivan
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Jureidini, Ricardo
da Cunha, José Eduardo Monteiro
Takeda, Flavio
Namur, Guilherme Naccache
Ribeiro, Thiago Costa
Patzina, Rosely
Figueira, Estela RR
Ribeiro Jr, Ulysses
Bacchella, Telesforo
Cecconello, Ivan
description OBJECTIVE: To evaluate the prognostic significance of microvessel density and p53 expression in pancreatic cancer. METHODS: Between 2008 and 2012, 49 patients with pancreatic adenocarcinoma underwent resection with curative intention. The resected specimens were immunohistochemically stained with anti-p53 and anti-CD34 antibodies. Microvessel density was assessed by counting vessels within ten areas of each tumoral section a highpower microscope. RESULTS: The microvessel density ranged from 21.2 to 54.2 vessels/mm2. Positive nuclear staining for p53 was found in 20 patients (40.6%). The overall median survival rate after resection was 24.1 months and there were no differences in survival rates related to microvessel density or p53 positivity. Microvessel density was associated with tumor diameter greater than 3.0 cm and with R0 resection failure. CONCLUSIONS: Microvessel density was associated with R1 resection and with larger tumors. p53 expression was not correlated with intratumoral microvessel density in pancreatic adenocarcinoma.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/117964
10.6061/clinics/2016(06)05
url https://www.revistas.usp.br/clinics/article/view/117964
identifier_str_mv 10.6061/clinics/2016(06)05
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/117964/115608
dc.rights.driver.fl_str_mv Copyright (c) 2016 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2016 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 71 No. 6 (2016); 315-319
Clinics; v. 71 n. 6 (2016); 315-319
Clinics; Vol. 71 Núm. 6 (2016); 315-319
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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