Avaliação da resposta humoral à vacina pneumocócica 7-valente em crianças com Aids

• Autor(a) principal: Costa, Isabel de Camargo
• Data de Publicação: 2008
• Outros Autores: Guilardi, Fabiana, Kmiliauskis, Mariana Acenjo, Arslanian, Christina, Baldacci, Evandro Roberto
• Tipo de documento: Artigo
• Idioma: por; eng
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32506
• topic: Vacinas Pneumocócicas; Fatores Imunológicos; Infecções Pneumocócicas^i1^sprevenção e contr; Infecções por HIV^i1^sprevenção e contr; Criança; Vacunas Neumococicas; Factores Inmunológicos; Infecciones Neumocócicas^i3^sprevención & cont; Infecciones por VIH^i3^sprevención & cont; Niño; Pneumococcal Vaccines; Immunologic Factors; Pneumococcal Infections^i2^sprevention & cont; HIV Infections^i2^sprevention & cont; Child

OBJECTIVE: Invasive pneumococcal disease is a major cause of death in HIV-infected children. The objective of the study was to assess the quantitative antibody response to the seven pneumococcal serotypes of heptavalent pneumococcal conjugate vaccine in a group of HIV-infected children. METHODS: Study comprising 40 HIV-infected children aged between 2 and 9 years followed up in a specialized outpatient clinic in São Paulo, Brazil, between 2002 and 2003. Enzyme immunoassay (ELISA) was used to measure IgG antibody titers against pneumococcus capsule. Antibodies were measured immediately before and 1 month after the second dose of the vaccine. Two response criteria were used: IgG titers >;1.3 µg/mL in the post-immunization serology and an increase of at least 4-fold in post- compared to pre-immunization serology. RESULTS: For the first criterion (>;1.3 µg/mL), 26 (65%) children had serological response to the vaccine, 12 (30%) showed post-immunization IgG titers of at least 1.3 µg/mL for all seven serotypes studied. For the second criterion studied (>;4-fold increase in post- compared to pre-immunization titers for four serotypes or more), serological response was seen in 15 (37.5%) children. CONCLUSIONS: Overall response to the heptavalent pneumococcal conjugate vaccine was adequate, showing a statistically significant increase in the post-immunization geometric mean titers for the seven serotypes studied.