Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo
Autor(a) principal: | |
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Data de Publicação: | 1986 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/23394 |
Resumo: | The study was performed in the State of S.Paulo, SP, Brazil, with the purpose of finding out whether reusable (glass) and disposable hypodermic syringes used for administration of live attenuated measles vaccines would interfere with their virus. At least six different experiments using two distinct lots of vaccines were carried out. Each time, a lot was reconstituted with reusable and disposable syringes in parallel to form separate pools from which samples were collected hourly from zero to the sixtieth hour after reconstitution for virus titration in monolayers of Vero cells. The straight line regression system chosen for the analysis of the results demonstrated that although vaccines reconstituted with both types of syringes presented a statistically significative titer decrease as time went by, there was a more pronounced decrease for vaccines manipulated with the glass syringes. The fact that the disposable syringes affected the titer of the virus present in the live, attenuated measles vaccine less confirmed that the preconization and routine usage of this type of syringe by the Health Department of the State of S.Paulo, Brazil, is ideal and highly recommended because it preserves the vaccine from reconstitution to administration better, and thus, its efficacy in preventing the infection. |
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Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo Disposable versus reusable hypodermic syringes: study of feasible effects upon the virus of the live, attenuated measles vaccine Vacina contra sarampoEficáciaSeringasEstudos comparativosMeasles vaccineEfficacySyringesComparative studies The study was performed in the State of S.Paulo, SP, Brazil, with the purpose of finding out whether reusable (glass) and disposable hypodermic syringes used for administration of live attenuated measles vaccines would interfere with their virus. At least six different experiments using two distinct lots of vaccines were carried out. Each time, a lot was reconstituted with reusable and disposable syringes in parallel to form separate pools from which samples were collected hourly from zero to the sixtieth hour after reconstitution for virus titration in monolayers of Vero cells. The straight line regression system chosen for the analysis of the results demonstrated that although vaccines reconstituted with both types of syringes presented a statistically significative titer decrease as time went by, there was a more pronounced decrease for vaccines manipulated with the glass syringes. The fact that the disposable syringes affected the titer of the virus present in the live, attenuated measles vaccine less confirmed that the preconization and routine usage of this type of syringe by the Health Department of the State of S.Paulo, Brazil, is ideal and highly recommended because it preserves the vaccine from reconstitution to administration better, and thus, its efficacy in preventing the infection. Objetivou-se verificar entre seringas hipodérmicas descartáveis e reutilizáveis qual interfere mais com o vírus vivo presente na vacina contra o sarampo. Vacinas pertencentes a dois lotes foram reconstituídas com os dois tipos de seringas, de modo a formarem dois pools distintos, mantidos à temperatura de +2 a+8°C e protegidos da luz. De cada lote foram realizadas, no mínimo, seis titulações em paralelo, com amostragem a cada hora, de zero a seis horas após reconstituição. A análise estatística dos resultados obtidos nas titulações, feita pelo sistema de retas de regressão demonstrou que embora as vacinas manipuladas com ambos os tipos de seringas apresentassem um decréscimo de título estatisticamente significativo com o decorrer das horas, ele foi bem mais acentuado para as vacinas reconstituídas com seringas reutilizáveis. A menor interferência das descartáveis no título da vacina viva, atenuada contra o sarampo, demonstrou que a preconização e uso desse tipo de seringas pela Secretaria de Estado da Saúde de São Paulo é o ideal e recomendável, por preservar mais a vacina desde a reconstituição até sua administração e, conseqüentemente, a sua eficácia na prevenção dessa infecção. Universidade de São Paulo. Faculdade de Saúde Pública1986-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/2339410.1590/S0034-89101986000600009Revista de Saúde Pública; Vol. 20 No. 6 (1986); 475-480 Revista de Saúde Pública; Vol. 20 Núm. 6 (1986); 475-480 Revista de Saúde Pública; v. 20 n. 6 (1986); 475-480 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/23394/25426Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessRizzo, Edda deFang, Francisco Liauw WoeGallina, Neuza Maria FrazattiTakata, Célia SayokoMiyaki, CosuePluciennik, Ana Maria AratangySato, AugustaPral, Michel MariePral, Elizabeth Mieko FurushoMendes, Inácio França2012-05-28T16:26:24Zoai:revistas.usp.br:article/23394Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-05-28T16:26:24Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo Disposable versus reusable hypodermic syringes: study of feasible effects upon the virus of the live, attenuated measles vaccine |
title |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
spellingShingle |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo Rizzo, Edda de Vacina contra sarampo Eficácia Seringas Estudos comparativos Measles vaccine Efficacy Syringes Comparative studies |
title_short |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
title_full |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
title_fullStr |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
title_full_unstemmed |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
title_sort |
Seringas hipodérmicas descartáveis versus reutilizáveis: estudo de possíveis efeitos sobre o vírus da vacina viva, atenuada contra o sarampo |
author |
Rizzo, Edda de |
author_facet |
Rizzo, Edda de Fang, Francisco Liauw Woe Gallina, Neuza Maria Frazatti Takata, Célia Sayoko Miyaki, Cosue Pluciennik, Ana Maria Aratangy Sato, Augusta Pral, Michel Marie Pral, Elizabeth Mieko Furusho Mendes, Inácio França |
author_role |
author |
author2 |
Fang, Francisco Liauw Woe Gallina, Neuza Maria Frazatti Takata, Célia Sayoko Miyaki, Cosue Pluciennik, Ana Maria Aratangy Sato, Augusta Pral, Michel Marie Pral, Elizabeth Mieko Furusho Mendes, Inácio França |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rizzo, Edda de Fang, Francisco Liauw Woe Gallina, Neuza Maria Frazatti Takata, Célia Sayoko Miyaki, Cosue Pluciennik, Ana Maria Aratangy Sato, Augusta Pral, Michel Marie Pral, Elizabeth Mieko Furusho Mendes, Inácio França |
dc.subject.por.fl_str_mv |
Vacina contra sarampo Eficácia Seringas Estudos comparativos Measles vaccine Efficacy Syringes Comparative studies |
topic |
Vacina contra sarampo Eficácia Seringas Estudos comparativos Measles vaccine Efficacy Syringes Comparative studies |
description |
The study was performed in the State of S.Paulo, SP, Brazil, with the purpose of finding out whether reusable (glass) and disposable hypodermic syringes used for administration of live attenuated measles vaccines would interfere with their virus. At least six different experiments using two distinct lots of vaccines were carried out. Each time, a lot was reconstituted with reusable and disposable syringes in parallel to form separate pools from which samples were collected hourly from zero to the sixtieth hour after reconstitution for virus titration in monolayers of Vero cells. The straight line regression system chosen for the analysis of the results demonstrated that although vaccines reconstituted with both types of syringes presented a statistically significative titer decrease as time went by, there was a more pronounced decrease for vaccines manipulated with the glass syringes. The fact that the disposable syringes affected the titer of the virus present in the live, attenuated measles vaccine less confirmed that the preconization and routine usage of this type of syringe by the Health Department of the State of S.Paulo, Brazil, is ideal and highly recommended because it preserves the vaccine from reconstitution to administration better, and thus, its efficacy in preventing the infection. |
publishDate |
1986 |
dc.date.none.fl_str_mv |
1986-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23394 10.1590/S0034-89101986000600009 |
url |
https://www.revistas.usp.br/rsp/article/view/23394 |
identifier_str_mv |
10.1590/S0034-89101986000600009 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/23394/25426 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 20 No. 6 (1986); 475-480 Revista de Saúde Pública; Vol. 20 Núm. 6 (1986); 475-480 Revista de Saúde Pública; v. 20 n. 6 (1986); 475-480 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221773261701120 |