Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology

Detalhes bibliográficos
Autor(a) principal: Filappi, Andreane
Data de Publicação: 2008
Outros Autores: Prestes, Danívia, Garmatz, Bruna, Lopes, Sônia dos Anjos, Cecim, Marcelo
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/26697
Resumo: The objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity.
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spelling Influence of the chronic administration of sodium fluoride in ovine hepatic function and histologyInfluência da administração crônica de fluoreto de sódio na função e histologia hepática de ovinosFlúorOvinoUrinaSoroFígadoFluorideSheepUrineSerumLiverThe objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity.O objetivo do presente estudo foi o de investigar o efeito da ingestão acumulativa de fluoreto de sódio sobre o metabolismo hepático de ovinos. O experimento foi conduzido com 12 animais da raça Texel x Ile de France, os quais foram divididos em dois grupos iguais. O grupo controle recebeu sal iodado (5 g de NaCl/animal + 0,2 ppm I/kg matéria seca) e o grupo tratado, o mesmo sal iodado adicionado de fluoreto de sódio (4,7 mg F/kg de peso corporal), diariamente, por um período de 150 dias. Amostras de sangue foram coletadas aos 60, 90, 120 e 150 dias de tratamento. Ainda, nesses mesmos momentos, com uma coleta também no tempo zero, os animais foram alojados em gaiolas metabólicas para obtenção de urina produzida em 24 horas. Após o sacrifício dos animais, uma amostra de fígado foi removida para avaliação histológica. Verificou-se elevação nas concentrações séricas e urinárias de F no grupo tratado. Quanto às concentrações séricas de proteína total, albumina e colesterol total, não houve diferença significativa entre os grupos, assim como não houve na atividade das enzimas gama glutamiltransferase e aspartato aminotransferase. No exame histológico do fígado, não foram observadas alterações. A administração de fluoreto de sódio na dose e duração deste estudo não induz a hepatotoxicidade.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2669710.11606/issn.1678-4456.bjvras.2008.26697Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 3 (2008); 200-2051678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/26697/28480Filappi, AndreanePrestes, DaníviaGarmatz, BrunaLopes, Sônia dos AnjosCecim, Marceloinfo:eu-repo/semantics/openAccess2020-06-23T04:13:31Zoai:revistas.usp.br:article/26697Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:58.594686Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
Influência da administração crônica de fluoreto de sódio na função e histologia hepática de ovinos
title Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
spellingShingle Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
Filappi, Andreane
Flúor
Ovino
Urina
Soro
Fígado
Fluoride
Sheep
Urine
Serum
Liver
title_short Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
title_full Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
title_fullStr Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
title_full_unstemmed Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
title_sort Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
author Filappi, Andreane
author_facet Filappi, Andreane
Prestes, Danívia
Garmatz, Bruna
Lopes, Sônia dos Anjos
Cecim, Marcelo
author_role author
author2 Prestes, Danívia
Garmatz, Bruna
Lopes, Sônia dos Anjos
Cecim, Marcelo
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Filappi, Andreane
Prestes, Danívia
Garmatz, Bruna
Lopes, Sônia dos Anjos
Cecim, Marcelo
dc.subject.por.fl_str_mv Flúor
Ovino
Urina
Soro
Fígado
Fluoride
Sheep
Urine
Serum
Liver
topic Flúor
Ovino
Urina
Soro
Fígado
Fluoride
Sheep
Urine
Serum
Liver
description The objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26697
10.11606/issn.1678-4456.bjvras.2008.26697
url https://www.revistas.usp.br/bjvras/article/view/26697
identifier_str_mv 10.11606/issn.1678-4456.bjvras.2008.26697
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26697/28480
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 3 (2008); 200-205
Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 3 (2008); 200-205
Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 3 (2008); 200-205
Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 3 (2008); 200-205
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
_version_ 1797051558846791680

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