Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/26697 |
Resumo: | The objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Influence of the chronic administration of sodium fluoride in ovine hepatic function and histologyInfluência da administração crônica de fluoreto de sódio na função e histologia hepática de ovinosFlúorOvinoUrinaSoroFígadoFluorideSheepUrineSerumLiverThe objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity.O objetivo do presente estudo foi o de investigar o efeito da ingestão acumulativa de fluoreto de sódio sobre o metabolismo hepático de ovinos. O experimento foi conduzido com 12 animais da raça Texel x Ile de France, os quais foram divididos em dois grupos iguais. O grupo controle recebeu sal iodado (5 g de NaCl/animal + 0,2 ppm I/kg matéria seca) e o grupo tratado, o mesmo sal iodado adicionado de fluoreto de sódio (4,7 mg F/kg de peso corporal), diariamente, por um período de 150 dias. Amostras de sangue foram coletadas aos 60, 90, 120 e 150 dias de tratamento. Ainda, nesses mesmos momentos, com uma coleta também no tempo zero, os animais foram alojados em gaiolas metabólicas para obtenção de urina produzida em 24 horas. Após o sacrifício dos animais, uma amostra de fígado foi removida para avaliação histológica. Verificou-se elevação nas concentrações séricas e urinárias de F no grupo tratado. Quanto às concentrações séricas de proteína total, albumina e colesterol total, não houve diferença significativa entre os grupos, assim como não houve na atividade das enzimas gama glutamiltransferase e aspartato aminotransferase. No exame histológico do fígado, não foram observadas alterações. A administração de fluoreto de sódio na dose e duração deste estudo não induz a hepatotoxicidade.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2669710.11606/issn.1678-4456.bjvras.2008.26697Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 3 (2008); 200-205Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 3 (2008); 200-2051678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/26697/28480Filappi, AndreanePrestes, DaníviaGarmatz, BrunaLopes, Sônia dos AnjosCecim, Marceloinfo:eu-repo/semantics/openAccess2020-06-23T04:13:31Zoai:revistas.usp.br:article/26697Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:58.594686Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology Influência da administração crônica de fluoreto de sódio na função e histologia hepática de ovinos |
title |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
spellingShingle |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology Filappi, Andreane Flúor Ovino Urina Soro Fígado Fluoride Sheep Urine Serum Liver |
title_short |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
title_full |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
title_fullStr |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
title_full_unstemmed |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
title_sort |
Influence of the chronic administration of sodium fluoride in ovine hepatic function and histology |
author |
Filappi, Andreane |
author_facet |
Filappi, Andreane Prestes, Danívia Garmatz, Bruna Lopes, Sônia dos Anjos Cecim, Marcelo |
author_role |
author |
author2 |
Prestes, Danívia Garmatz, Bruna Lopes, Sônia dos Anjos Cecim, Marcelo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Filappi, Andreane Prestes, Danívia Garmatz, Bruna Lopes, Sônia dos Anjos Cecim, Marcelo |
dc.subject.por.fl_str_mv |
Flúor Ovino Urina Soro Fígado Fluoride Sheep Urine Serum Liver |
topic |
Flúor Ovino Urina Soro Fígado Fluoride Sheep Urine Serum Liver |
description |
The objective of the present study was to investigate the effect a prolonged and high of sodium fluoride intake on liver metabolism in ovine. The trial involved 12 Texel x Ile de France animals, which were divided into two equal groups. The control group was treated daily with iodized salt (5 g NaCl/animal + 0.2 ppm I/kg dry matter) and the experimental group, with received the same iodized salt added of sodium fluoride (4.7 mg F/kg body weight) for 150 days. Blood samples were collected on days 60, 90, 120 and 150 of the treatment. Besides, on same days and with samples collected also at time zero, animals were placed in metabolic cages for a 24-h collection of urine samples. After animals were euthanized, a liver sample was collected for histological analysis. Fluoride concentrations in the serum and urine were increased in the experimental group. No statistical differences were observed in total protein, albumin and total cholesterol serum concentrations, and in the activities of the enzymes gamma glutamyl transferase and aspartate aminotransferase. No changes were observed in the histological analysis of the liver. The administration of sodium fluoride in the dose used and during the period analyzed in the present study does not lead to hepatotoxicity. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26697 10.11606/issn.1678-4456.bjvras.2008.26697 |
url |
https://www.revistas.usp.br/bjvras/article/view/26697 |
identifier_str_mv |
10.11606/issn.1678-4456.bjvras.2008.26697 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/26697/28480 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 Núm. 3 (2008); 200-205 Brazilian Journal of Veterinary Research and Animal Science; Vol. 45 No. 3 (2008); 200-205 Brazilian Journal of Veterinary Research and Animal Science; v. 45 n. 3 (2008); 200-205 Brazilian Journal of Veterinary Research and Animal Science; V. 45 N. 3 (2008); 200-205 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051558846791680 |