Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus
Autor(a) principal: | |
---|---|
Data de Publicação: | 2002 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Hospital das Clínicas |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000600006 |
Resumo: | OBJECTIVE: To analyze the frequency of human leukocyte antigens class II-DR in children and adolescents with systemic lupus erythematosus. PATIENTS AND METHODS: Fifty-fiveBrazilian systemic lupus erythematosus children and adolescents and 308 healthy individuals were studied. Gender, race, and age of onset of systemic lupus erythematosus were recorded. The human leukocyte antigens typing of class II-DR was carried out by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Data were analyzed statistically using the chi square test with Yates' correction, Fisher's exact test, and Bonferroni's correction. RESULTS: Human leukocyte antigen-DR 15 was the most frequently detected antigen in this group of children and adolescents, and it also occurred more frequently in the female group, in children with onset of systemic lupus erythematosus between 0 and 9 years and between 10 to 14 years, and in the Black race group, but these associations were not statistically significants. CONCLUSION: In this group of children and adolescents with a high degree of racial admixture, we could not verify a significant association between human leukocyte antigens class II-DR and systemic lupus erythematosus. |
id |
USP-57_3775aee1e34232ed1195ba3c031dd985 |
---|---|
oai_identifier_str |
oai:scielo:S0041-87812002000600006 |
network_acronym_str |
USP-57 |
network_name_str |
Revista do Hospital das Clínicas |
repository_id_str |
|
spelling |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosusSystemic lupus erythematosusHuman leukocyte antigensChildren and adolescentsOBJECTIVE: To analyze the frequency of human leukocyte antigens class II-DR in children and adolescents with systemic lupus erythematosus. PATIENTS AND METHODS: Fifty-fiveBrazilian systemic lupus erythematosus children and adolescents and 308 healthy individuals were studied. Gender, race, and age of onset of systemic lupus erythematosus were recorded. The human leukocyte antigens typing of class II-DR was carried out by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Data were analyzed statistically using the chi square test with Yates' correction, Fisher's exact test, and Bonferroni's correction. RESULTS: Human leukocyte antigen-DR 15 was the most frequently detected antigen in this group of children and adolescents, and it also occurred more frequently in the female group, in children with onset of systemic lupus erythematosus between 0 and 9 years and between 10 to 14 years, and in the Black race group, but these associations were not statistically significants. CONCLUSION: In this group of children and adolescents with a high degree of racial admixture, we could not verify a significant association between human leukocyte antigens class II-DR and systemic lupus erythematosus.Faculdade de Medicina / Universidade de São Paulo - FM/USP2002-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000600006Revista do Hospital das Clínicas v.57 n.6 2002reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812002000600006info:eu-repo/semantics/openAccessLiphaus,Bernadete de L.Goldberg,Anna CarlaKiss,Maria Helena B.Silva,Clovis A. A.eng2003-02-17T00:00:00Zoai:scielo:S0041-87812002000600006Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2003-02-17T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
title |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
spellingShingle |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus Liphaus,Bernadete de L. Systemic lupus erythematosus Human leukocyte antigens Children and adolescents |
title_short |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
title_full |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
title_fullStr |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
title_full_unstemmed |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
title_sort |
Analysis of human leukocyte antigens class II-DR in Brazilian children and adolescents with systemic lupus erythematosus |
author |
Liphaus,Bernadete de L. |
author_facet |
Liphaus,Bernadete de L. Goldberg,Anna Carla Kiss,Maria Helena B. Silva,Clovis A. A. |
author_role |
author |
author2 |
Goldberg,Anna Carla Kiss,Maria Helena B. Silva,Clovis A. A. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Liphaus,Bernadete de L. Goldberg,Anna Carla Kiss,Maria Helena B. Silva,Clovis A. A. |
dc.subject.por.fl_str_mv |
Systemic lupus erythematosus Human leukocyte antigens Children and adolescents |
topic |
Systemic lupus erythematosus Human leukocyte antigens Children and adolescents |
description |
OBJECTIVE: To analyze the frequency of human leukocyte antigens class II-DR in children and adolescents with systemic lupus erythematosus. PATIENTS AND METHODS: Fifty-fiveBrazilian systemic lupus erythematosus children and adolescents and 308 healthy individuals were studied. Gender, race, and age of onset of systemic lupus erythematosus were recorded. The human leukocyte antigens typing of class II-DR was carried out by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP). Data were analyzed statistically using the chi square test with Yates' correction, Fisher's exact test, and Bonferroni's correction. RESULTS: Human leukocyte antigen-DR 15 was the most frequently detected antigen in this group of children and adolescents, and it also occurred more frequently in the female group, in children with onset of systemic lupus erythematosus between 0 and 9 years and between 10 to 14 years, and in the Black race group, but these associations were not statistically significants. CONCLUSION: In this group of children and adolescents with a high degree of racial admixture, we could not verify a significant association between human leukocyte antigens class II-DR and systemic lupus erythematosus. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000600006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812002000600006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0041-87812002000600006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
dc.source.none.fl_str_mv |
Revista do Hospital das Clínicas v.57 n.6 2002 reponame:Revista do Hospital das Clínicas instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista do Hospital das Clínicas |
collection |
Revista do Hospital das Clínicas |
repository.name.fl_str_mv |
Revista do Hospital das Clínicas - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||revista.hc@hcnet.usp.br |
_version_ |
1754820894501371904 |